The activity of 2'-benzoyloxycinnamaldehyde against drug-resistant cancer cell lines.

Chung, YM ; Yoo, YD ; et al.

In: Journal of chemotherapy (Florence, Italy), Jg. 19 (2007-08-01), Heft 4, S. 428-37

academicJournal

This study investigated the inhibitory effects of 2'-benzoyloxycinnamaldehyde (BCA) on cancer cells, including various drug-resistant cancer cell lines. To observe this activity, the anticancer drug-resistant cell lines were established by continuously exposing the parental cells to 5-fluorouracil (5-FU) and cyclophosphamide (CDDP), and examining the cells with the MTT assay and flow cytometric analysis. The BCA treatment produced similar growth inhibitory effects and apoptotic cell death on the drug-resistant cancer cells as their parental cells. The activation of the p38-mitogen activated protein kinase, an increased level of reactive oxygen species (ROS) generation and downregulation of Bcl-2 were observed in both the drug resistant and non-drug resistant cell lines. The GSH treatment effectively inhibited BCA-induced apoptosis by blocking ROS generation, suggesting that ROS is a major regulator in BCA-induced apoptotic cell death. These results suggest that BCA can be a useful drug candidate for treating drug-resistant cells.

Titel:	The activity of 2'-benzoyloxycinnamaldehyde against drug-resistant cancer cell lines.
Autor/in / Beteiligte Person:	Chung, YM ; Yoo, YD ; Kim, JS ; Lee, CY ; Kim, HJ
Zeitschrift:	Journal of chemotherapy (Florence, Italy), Jg. 19 (2007-08-01), Heft 4, S. 428-37
Veröffentlichung:	2016- : Abingdon : Taylor & Francis ; <i>Original Publication</i>: Firenze : Edizioni riviste scientifiche, [1989-, 2007
Medientyp:	academicJournal
ISSN:	1120-009X (print)
DOI:	10.1179/joc.2007.19.4.428
Schlagwort:	Acrolein pharmacology Cell Line, Tumor Flow Cytometry Humans Proto-Oncogene Proteins c-bcl-2 metabolism Reactive Oxygen Species metabolism p38 Mitogen-Activated Protein Kinases metabolism Acrolein analogs & derivatives Antineoplastic Agents pharmacology Apoptosis Benzoates pharmacology Cell Proliferation drug effects Drug Resistance, Neoplasm Neoplasms metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Chemother] 2007 Aug; Vol. 19 (4), pp. 428-37. MeSH Terms: Apoptosis* ; Drug Resistance, Neoplasm* ; Acrolein / analogs & derivatives ; Antineoplastic Agents / pharmacology ; Benzoates / pharmacology ; Cell Proliferation / drug effects ; Neoplasms / *metabolism ; Acrolein / pharmacology ; Cell Line, Tumor ; Flow Cytometry ; Humans ; Proto-Oncogene Proteins c-bcl-2 / metabolism ; Reactive Oxygen Species / metabolism ; p38 Mitogen-Activated Protein Kinases / metabolism Substance Nomenclature: 0 (2'-benzoyloxycinnamaldehyde) ; 0 (Antineoplastic Agents) ; 0 (Benzoates) ; 0 (Proto-Oncogene Proteins c-bcl-2) ; 0 (Reactive Oxygen Species) ; 7864XYD3JJ (Acrolein) ; EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases) Entry Date(s): Date Created: 20070915 Date Completed: 20071011 Latest Revision: 20131121 Update Code: 20240513

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