[Two cases treated with trastuzumab as primary chemotherapy].
In: Gan to kagaku ryoho. Cancer & chemotherapy, Jg. 34 (2007-10-01), Heft 10, S. 1683-7
academicJournal
Zugriff:
We report two cases treated with primary chemotherapy containing trastuzumab with a review of some important papers. The first patient was a 43-year-old female. A 33-mm left breast invasive ductal carcinoma (ER (-), PgR (-), HER2 3+(IHC) ) with several lymph node metastases in the Ax, Ic and Sc was found. After primary chemotherapy with 6 courses of EC and 4 courses of weekly paclitaxel + trastuzumab, the efficacy for the local tumor was judged as PR. However, brain metastases appeared, so the operation was canceled. Brain metastases were then treated by gamma-knife three times, but systemic chemotherapy was not administered. Eight months later, carcinomatous meningitis appeared. Intrathecal chemotherapy with MTX+Ara-C was started, but the patient died after 20 months from the beginning of the treatment. Local efficacy was judged as CR. The second patient was a 41-year-old female. A 39-mm right breast invasive ductal carcinoma (ER (-), PgR (-), HER2 3+(IHC) ) with two lymph node metastases in the Ax was found. After primary chemotherapy with 6 courses of FEC and 4 courses of weekly paclitaxel + trastuzumab, the efficacy was judged as PR. The operation was scheduled, but he patient wished to continue chemotherapy for cosmetic reasons. Later, because of mild tumor regrowth, we used 2 courses of vinorelbine in combination with trastuzumab. The tumor grew more, so Bp + Ax was done. The woman is alive at this writing with no recurrence.
Titel: |
[Two cases treated with trastuzumab as primary chemotherapy].
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Autor/in / Beteiligte Person: | Murakami, K ; Sakata, H ; Miyazawa, Y ; Matsushita, K ; Akutsu, Y ; Nishimori, T ; Yoneyama, Y ; Usui, A ; Kano, M ; Matsubara, H ; Ochiai, T |
Zeitschrift: | Gan to kagaku ryoho. Cancer & chemotherapy, Jg. 34 (2007-10-01), Heft 10, S. 1683-7 |
Veröffentlichung: | Tokyo : Gan To Kagaku Ryohosha ; <i>Original Publication</i>: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]-, 2007 |
Medientyp: | academicJournal |
ISSN: | 0385-0684 (print) |
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