Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).
In: Archives of biochemistry and biophysics, Jg. 468 (2007-12-01), Heft 1, S. 134-9
academicJournal
Zugriff:
To investigate the signal transduction pathway of caspase-2, cell permeable Tat-reverse-caspase-2 was constructed, characterized and utilized for biochemical and cellular studies. It could induce the cell death as early as 2h, and caspase-2-specific VDVADase activity but not other caspase activities including DEVDase and IETDase. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation.
Titel: |
Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD).
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Autor/in / Beteiligte Person: | Dahal, GR ; Karki, P ; Thapa, A ; Shahnawaz, M ; Shin, SY ; Lee, JS ; Cho, B ; Park, IS |
Zeitschrift: | Archives of biochemistry and biophysics, Jg. 468 (2007-12-01), Heft 1, S. 134-9 |
Veröffentlichung: | <2000- > : San Diego, CA : Elsevier ; <i>Original Publication</i>: New York, NY : Academic Press, 2007 |
Medientyp: | academicJournal |
ISSN: | 1096-0384 (electronic) |
DOI: | 10.1016/j.abb.2007.09.007 |
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