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Background: Src-family tyrosine kinases (SFKs) are important regulators of keratinocyte growth and differentiation. In a broad range of cell types, persistent activation of SFKs correlates with increased cell proliferation. In this study, we determined if SFK activity is increased in cutaneous neoplasia and psoriasis, common hyperproliferative epidermal disorders.

Methods: Formalin-fixed tissue sections of unremarkable epidermis, psoriasis, actinic keratoses (AKs), squamous cell carcinoma in situ (SCIS) and squamous cell carcinoma (SCC) were subjected to immunohistochemical staining for activated SFKs.

Results: All psoriasis specimens displayed significantly greater staining for activated SFKs than sections of unremarkable skin. In the psoriasis biopsies, the degree of epidermal hyperplasia was proportional to the level of activated SFK staining. All AKs, SCISs and SCCs exhibited more prominent staining than sections of unremarkable epidermis. No discernable difference in activated SFK staining was seen between AKs, SCIS and SCC specimens.

Conclusions: This study shows increased staining of activated SFKs in human biopsy specimens of psoriasis and cutaneous neoplasia. These data provide direct evidence for increased activation of SFKs in the pathogenesis of hyperproliferative epidermal disorders.

Titel:	Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders.
Autor/in / Beteiligte Person:	Ayli, EE ; Li, W ; Brown, TT ; Witkiewicz, A ; Elenitsas, R ; Seykora, JT
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of cutaneous pathology, Jg. 35 (2008-03-01), Heft 3, S. 273-7
Veröffentlichung:	Malden, MA : Wiley ; <i>Original Publication</i>: Copenhagen, Blackwell Munksgaard., 2008
Medientyp:	academicJournal
ISSN:	1600-0560 (electronic)
DOI:	10.1111/j.1600-0560.2007.00807.x
Schlagwort:	Biomarkers, Tumor metabolism Carcinoma in Situ pathology Carcinoma, Squamous Cell pathology Epidermis anatomy & histology Epidermis enzymology Fluorescent Antibody Technique, Indirect Humans Immunoenzyme Techniques Photosensitivity Disorders pathology Psoriasis pathology Skin Neoplasms pathology Carcinoma in Situ enzymology Carcinoma, Squamous Cell enzymology Photosensitivity Disorders enzymology Psoriasis enzymology Skin Neoplasms enzymology src-Family Kinases biosynthesis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Cutan Pathol] 2008 Mar; Vol. 35 (3), pp. 273-7. MeSH Terms: Carcinoma in Situ / enzymology ; Carcinoma, Squamous Cell / enzymology ; Photosensitivity Disorders / enzymology ; Psoriasis / enzymology ; Skin Neoplasms / enzymology ; src-Family Kinases / biosynthesis ; Biomarkers, Tumor / metabolism ; Carcinoma in Situ / pathology ; Carcinoma, Squamous Cell / pathology ; Epidermis / anatomy & histology ; Epidermis / enzymology ; Fluorescent Antibody Technique, Indirect ; Humans ; Immunoenzyme Techniques ; Photosensitivity Disorders / pathology ; Psoriasis / pathology ; Skin Neoplasms / pathology References: Exp Cell Res. 2000 Jan 10;254(1):1-13. (PMID: 10623460) ; Curr Opin Cell Biol. 1995 Apr;7(2):176-82. (PMID: 7612268) ; Nat Med. 2005 Jan;11(1):43-9. (PMID: 15592573) ; N Engl J Med. 2005 May 5;352(18):1899-912. (PMID: 15872205) ; J Biol Chem. 2002 Jan 25;277(4):2812-22. (PMID: 11711534) ; Nature. 2005 Sep 15;437(7057):369-75. (PMID: 16163348) ; J Biol Chem. 2005 Feb 18;280(7):6036-46. (PMID: 15579470) ; Genes Dev. 1995 Sep 15;9(18):2279-91. (PMID: 7557381) ; J Biol Chem. 2007 Jan 12;282(2):1161-9. (PMID: 17046829) ; Exp Cell Res. 2003 Mar 10;284(1):31-53. (PMID: 12648464) Grant Information: K08 AR047597 United States AR NIAMS NIH HHS; R01 AR051380 United States AR NIAMS NIH HHS; R01 AR051380-02 United States AR NIAMS NIH HHS; R01 AR051380-03 United States AR NIAMS NIH HHS Substance Nomenclature: 0 (Biomarkers, Tumor) ; EC 2.7.10.2 (src-Family Kinases) Entry Date(s): Date Created: 20080207 Date Completed: 20080304 Latest Revision: 20220309 Update Code: 20240513 PubMed Central ID: PMC3099403

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Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders.