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Serotonin (5-HT) modulates emotional and cognitive functions such as fear conditioning (FC) and decision making. This study investigated the effects of a functional polymorphism in the regulatory region (5-HTTLPR) of the human 5-HT transporter (5-HTT) gene on observational FC, risk taking and susceptibility to framing in decision making under uncertainty, as well as multidimensional anxiety and autonomic control of the heart in healthy volunteers. The present results indicate that in comparison to the homozygotes for the long (l) version of 5-HTTLPR, the carriers of the short (s) version display enhanced observational FC, reduced financial risk taking and increased susceptibility to framing in economic decision making. We also found that s-carriers have increased trait anxiety due to threat in social evaluation, and ambiguous threat perception. In addition, s-carriers also show reduced autonomic control over the heart, and a pattern of reduced vagal tone and increased sympathetic activity in comparison to l-homozygotes. This is the first genetic study that identifies the association of a functional polymorphism in a key neurotransmitter-related gene with complex social-emotional and cognitive processes. The present set of results suggests an endophenotype of anxiety disorders, characterized by enhanced social learning of fear, impaired decision making and dysfunctional autonomic activity.

Titel:	Genetic contributions of the serotonin transporter to social learning of fear and economic decision making.
Autor/in / Beteiligte Person:	Crişan, LG ; Pana, S ; Vulturar, R ; Heilman, RM ; Szekely, R ; Druğa, B ; Dragoş, N ; Miu, AC
Link:	Full Text Finder (Volltext)
Zeitschrift:	Social cognitive and affective neuroscience, Jg. 4 (2009-12-01), Heft 4, S. 399-408
Veröffentlichung:	Oxford, UK : Oxford Journals, Oxford University Press, 2009
Medientyp:	academicJournal
ISSN:	1749-5024 (electronic)
DOI:	10.1093/scan/nsp019
Schlagwort:	Adult Analysis of Variance Anxiety genetics Anxiety psychology Electrocardiography methods Female Heart Rate genetics Humans Male Polymorphism, Genetic genetics Respiration genetics Risk-Taking Self Concept Vagus Nerve physiology Young Adult Decision Making physiology Economics Fear physiology Learning physiology Serotonin Plasma Membrane Transport Proteins genetics Social Perception
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Soc Cogn Affect Neurosci] 2009 Dec; Vol. 4 (4), pp. 399-408. <i>Date of Electronic Publication: </i>2009 Jun 17. MeSH Terms: Economics* ; Social Perception* ; Decision Making / physiology ; Fear / physiology ; Learning / physiology ; Serotonin Plasma Membrane Transport Proteins / genetics ; Adult ; Analysis of Variance ; Anxiety / genetics ; Anxiety / psychology ; Electrocardiography / methods ; Female ; Heart Rate / genetics ; Humans ; Male ; Polymorphism, Genetic / genetics ; Respiration / genetics ; Risk-Taking ; Self Concept ; Vagus Nerve / physiology ; Young Adult References: J Pers Soc Psychol. 1978 Mar;36(3):271-9. (PMID: 650384) ; J Exp Psychol Gen. 1993 Mar;122(1):23-38. (PMID: 8440976) ; Trends Cogn Sci. 2008 Feb;12(2):65-71. (PMID: 18178513) ; Hum Genet. 1997 Dec;101(2):243-6. (PMID: 9402979) ; Am J Psychiatry. 2006 Sep;163(9):1588-93. (PMID: 16946185) ; Neuropsychopharmacology. 2003 Jan;28(1):153-62. (PMID: 12496952) ; Adv Health Econ Health Serv Res. 2008;20:55-84. (PMID: 19552304) ; Biol Psychol. 2008 Mar;77(3):353-8. (PMID: 18191013) ; Behav Neurosci. 2007 Apr;121(2):257-63. (PMID: 17469915) ; Soc Cogn Affect Neurosci. 2007 Mar;2(1):3-11. (PMID: 18985115) ; Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1687-8. (PMID: 19193858) ; Psychol Rev. 1962 Sep;69:450-66. (PMID: 13867454) ; Psychol Sci. 2009 Feb;20(2):198-206. (PMID: 19175757) ; Biol Psychiatry. 2007 Nov 15;62(10):1111-8. (PMID: 17524369) ; Science. 1997 Feb 28;275(5304):1293-5. (PMID: 9036851) ; Am Heart J. 2000 Oct;140(4 Suppl):77-83. (PMID: 11011352) ; PLoS One. 2009;4(2):e4362. (PMID: 19209222) ; Trends Cogn Sci. 2007 Apr;11(4):168-76. (PMID: 17337237) ; Science. 2008 Jun 27;320(5884):1739. (PMID: 18535210) ; Psychopharmacology (Berl). 2008 Jan;196(1):29-38. (PMID: 17940752) ; Proc Natl Acad Sci U S A. 2005 May 17;102(20):7398-401. (PMID: 15878990) ; Psychol Sci. 2008 Feb;19(2):112-3. (PMID: 18271857) ; J Psychopharmacol. 2007 Sep;21(7):684-90. (PMID: 17259206) ; Nature. 2008 Aug 28;454(7208):1079-83. (PMID: 18756249) ; Psychophysiology. 1997 Nov;34(6):623-48. (PMID: 9401419) ; Biol Psychiatry. 2004 Jun 15;55(12):1171-8. (PMID: 15184036) ; Behav Res Ther. 2002 Mar;40(3):279-87. (PMID: 11863238) ; Neurosci Lett. 2008 May 30;437(2):158-61. (PMID: 18448251) ; Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1263-8. (PMID: 18495314) ; Child Neuropsychol. 2009 Jan;15(1):73-84. (PMID: 18720101) ; Annu Rev Psychol. 2006;57:27-53. (PMID: 16318588) ; Am J Med Genet. 2001 Jul 8;105(5):458-63. (PMID: 11449399) ; Scand J Psychol. 2009 Feb;50(1):5-10. (PMID: 18826425) ; Nat Neurosci. 2007 Sep;10(9):1103-9. (PMID: 17726476) ; Psychosom Med. 2008 Apr;70(3):328-37. (PMID: 18378862) ; Psychosom Med. 2007 Sep-Oct;69(7):614-20. (PMID: 17766691) ; J Exp Psychol Appl. 2002 Jun;8(2):75-84. (PMID: 12075692) ; Depress Anxiety. 2006;23(1):6-10. (PMID: 16216019) ; Psychol Sci. 2004 Dec;15(12):822-8. (PMID: 15563327) ; J Appl Psychol. 1997 Aug;82(4):614-22. (PMID: 9378686) ; J Neurosci. 2008 Jul 9;28(28):7036-9. (PMID: 18614671) ; Am J Psychiatry. 1998 Mar;155(3):373-9. (PMID: 9501748) ; J Pers Soc Psychol. 2008 Apr;94(4):600-14. (PMID: 18361674) ; Curr Biol. 2007 Aug 21;17(16):R724-32. (PMID: 17714666) ; Soc Cogn Affect Neurosci. 2008 Jun;3(2):144-60. (PMID: 19015105) ; Biol Psychol. 2007 Feb;74(2):185-99. (PMID: 17069959) ; Biol Psychiatry. 2008 Jul 1;64(1):48-61. (PMID: 18549876) ; Psychopharmacology (Berl). 2003 Aug;169(1):104-7. (PMID: 12719963) ; Biol Psychiatry. 1998 Aug 1;44(3):207-19. (PMID: 9693392) ; Auton Neurosci. 2009 Jan 28;145(1-2):99-103. (PMID: 19059813) ; Science. 2007 Oct 26;318(5850):602-6. (PMID: 17962553) ; Nat Neurosci. 2001 Apr;4(4):437-41. (PMID: 11276236) ; Lancet. 2008 Mar 29;371(9618):1115-25. (PMID: 18374843) ; Annu Rev Neurosci. 2000;23:155-84. (PMID: 10845062) ; Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1720-4. (PMID: 19171900) ; Neuron. 2008 Jun 12;58(5):662-71. (PMID: 18549779) ; Psychiatr Danub. 2006 Jun;18(1-2):83-9. (PMID: 16804504) ; Science. 1989 May 26;244(4907):933-8. (PMID: 2658056) ; Biol Psychiatry. 2006 May 15;59(10):888-97. (PMID: 16442081) ; Neuroimage. 2006 Feb 1;29(3):1007-12. (PMID: 16246595) ; Annu Rev Clin Psychol. 2005;1:167-95. (PMID: 17716086) ; Psychopharmacology (Berl). 2003 Jun;167(4):411-7. (PMID: 12677354) ; Science. 2006 Aug 4;313(5787):684-7. (PMID: 16888142) ; Philos Trans R Soc Lond B Biol Sci. 2008 Dec 12;363(1511):3875-86. (PMID: 18829429) ; Science. 1981 Jan 30;211(4481):453-8. (PMID: 7455683) Substance Nomenclature: 0 (SLC6A4 protein, human) ; 0 (Serotonin Plasma Membrane Transport Proteins) Entry Date(s): Date Created: 20090619 Date Completed: 20100303 Latest Revision: 20220321 Update Code: 20240513 PubMed Central ID: PMC2799947

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Genetic contributions of the serotonin transporter to social learning of fear and economic decision making.