Einzeltreffer — DigiBib

A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to HIV infection and progression to AIDS. The present study aimed at evaluating the role of IL-6 and IL-10 gene polymorphisms on the risk of HIV susceptibility and disease progression among North Indian patients. The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were applied to genotype IL-6 and IL-10. 300 seropositive and an equal number of age- and sex-matched seronegative control subjects were recruited for this study. There was statistically no significant variation in the frequencies of IL-6 and IL-10 genotypes among cases and controls. However, statistically non-significant association for risk of rapid disease progression was observed due to the combined effect of the IL-6 homozygous CC genotype and CC of IL-10, OR = 1.62, 95% CI = 0.38-6.91. Therefore, combined effects of the CC of IL-6 and CC of IL-10 might reduce the hosts ability to hinder viral replication after infection.

Titel:	Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population.
Autor/in / Beteiligte Person:	Sobti, RC ; Berhane, N ; Mahedi, SA ; Kler, R ; Hosseini, SA ; Kuttiat, V ; Wanchu, A
Link:	Full Text Finder (Volltext)
Zeitschrift:	Molecular and cellular biochemistry, Jg. 337 (2010-04-01), Heft 1-2, S. 145-52
Veröffentlichung:	New York : Springer ; <i>Original Publication</i>: The Hague, Dr. W. Junk B. V. Publishers., 2010
Medientyp:	academicJournal
ISSN:	1573-4919 (electronic)
DOI:	10.1007/s11010-009-0293-0
Schlagwort:	Acquired Immunodeficiency Syndrome epidemiology Adult Case-Control Studies DNA Mutational Analysis Disease Progression Female Gene Frequency Genetic Predisposition to Disease Genotype HIV-1 Humans India epidemiology Male Middle Aged Polymorphism, Restriction Fragment Length Risk Factors Acquired Immunodeficiency Syndrome genetics Interleukin-10 genetics Interleukin-6 genetics Polymorphism, Single Nucleotide physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Mol Cell Biochem] 2010 Apr; Vol. 337 (1-2), pp. 145-52. MeSH Terms: Polymorphism, Single Nucleotide* / physiology ; Acquired Immunodeficiency Syndrome / genetics ; Interleukin-10 / genetics ; Interleukin-6 / *genetics ; Acquired Immunodeficiency Syndrome / epidemiology ; Adult ; Case-Control Studies ; DNA Mutational Analysis ; Disease Progression ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; HIV-1 ; Humans ; India / epidemiology ; Male ; Middle Aged ; Polymorphism, Restriction Fragment Length ; Risk Factors References: J Leukoc Biol. 2005 Nov;78(5):1043-51. (PMID: 16204623) ; Eur J Immunogenet. 1997 Feb;24(1):1-8. (PMID: 9043871) ; J Biol Chem. 2000 Jun 16;275(24):18138-44. (PMID: 10747905) ; Psychosom Med. 2003 Mar-Apr;65(2):181-93. (PMID: 12651985) ; Immunol Today. 1996 Jan;17(1):21-4. (PMID: 8652046) ; Curr Opin Immunol. 1998 Dec;10(6):649-55. (PMID: 9914214) ; Blood. 2001 Sep 1;98(5):1594-600. (PMID: 11520812) ; Chest. 2000 Apr;117(4):1162-72. (PMID: 10767254) ; Nephrol Dial Transplant. 2003 Jun;18(6):1042-5. (PMID: 12748331) ; J Immunol. 1995 Aug 15;155(4):2240-7. (PMID: 7636270) ; AIDS Rev. 2003 Apr-Jun;5(2):87-103. (PMID: 12876898) ; J Clin Invest. 1998 Oct 1;102(7):1369-76. (PMID: 9769329) ; Lancet. 1996 Nov 16;348(9038):1347-51. (PMID: 8918278) ; Sci Am. 1997 Sep;277(3):44-51. (PMID: 9274039) ; Cancer Lett. 1996 Jun 24;104(1):1-5. (PMID: 8640735) ; Eur Heart J. 2001 Dec;22(24):2243-52. (PMID: 11728144) ; J Infect Dis. 1996 Nov;174(5):994-1000. (PMID: 8896500) ; FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):129-36. (PMID: 16051064) ; Immunol Today. 1999 Jun;20(6):247-51. (PMID: 10354547) ; Science. 1992 Oct 23;258(5082):593-7. (PMID: 1411569) ; Semin Liver Dis. 1999;19(2):141-55. (PMID: 10422197) ; Breast Cancer Res Treat. 2005 Mar;90(2):113-5. (PMID: 15803357) ; Curr Opin Immunol. 1995 Aug;7(4):448-55. (PMID: 7495507) ; Am J Kidney Dis. 1998 Jul;32(1):107-14. (PMID: 9669431) ; Arthritis Rheum. 1994 Nov;37(11):1647-55. (PMID: 7980676) ; AIDS. 1990 Nov;4(11):1059-66. (PMID: 2282177) ; Science. 1991 Nov 15;254(5034):963-9. (PMID: 1683006) ; Lancet. 1997 Jun 28;349(9069):1912-3. (PMID: 9217780) ; Immunology. 1992 May;76(1):20-3. (PMID: 1321092) ; N Engl J Med. 1989 Oct 5;321(14):947-52. (PMID: 2779617) ; J Immunol. 1993 Jan 15;150(2):353-60. (PMID: 8419468) ; Lancet. 1993 Jan 16;341(8838):146-8. (PMID: 8093746) ; Cancer Res. 2003 Nov 15;63(22):8051-6. (PMID: 14633738) ; Emerg Infect Dis. 1997 Jul-Sep;3(3):261-71. (PMID: 9284370) ; Rheumatology (Oxford). 2001 Jun;40(6):656-61. (PMID: 11426023) ; Crit Care Med. 1993 Sep;21(9):1396-400. (PMID: 8396525) ; Cell. 1993 Oct 22;75(2):263-74. (PMID: 8402911) ; Cardiovasc Res. 2002 Mar;53(4):1029-34. (PMID: 11922913) ; J Exp Med. 1991 Nov 1;174(5):1209-20. (PMID: 1940799) ; Indian J Med Res. 2005 Apr;121(4):356-68. (PMID: 15817949) ; Genes Immun. 1999 Nov;1(2):151-5. (PMID: 11196662) ; J Clin Invest. 2005 Feb;115(2):443-50. (PMID: 15668739) ; J Immunol. 1995 Jul 15;155(2):722-9. (PMID: 7608550) ; Mol Hum Reprod. 2007 Feb;13(2):135-40. (PMID: 17178764) ; Transplantation. 2001 Aug 27;72(4):720-6. (PMID: 11544437) ; BMC Med. 2006 Apr 12;4:10. (PMID: 16611358) ; J Exp Med. 1994 Dec 1;180(6):2371-6. (PMID: 7964510) ; Nat Med. 2002 Aug;8(8):783-5. (PMID: 12152029) ; J Immunol. 1997 Jan 1;158(1):315-21. (PMID: 8977205) Substance Nomenclature: 0 (IL10 protein, human) ; 0 (IL6 protein, human) ; 0 (Interleukin-6) ; 130068-27-8 (Interleukin-10) Entry Date(s): Date Created: 20091126 Date Completed: 20100617 Latest Revision: 20211020 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population.