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Purpose: Our purpose in this study was to compare the impact of contrast material volume in delayed-enhancement computer tomography (CT) imaging for assessing acute reperfused myocardial infarction.

Materials and Methods: In five domestic pigs (20-30 kg), the circumflex coronary artery (CX) was balloon-occluded for 2 h followed by reperfusion. After 5 days, CT imaging was performed after intravenous administration of iodinated contrast material (Iomeprol 400 mgI/ml; Bracco, Italy). A 64-slice multidetector CT (MDCT) (Sensation 64, Siemens) scanner was used for imaging, with standard angiography characteristics. Three scans were performed: first, coronary angiography at first pass with 1.25 gI/kg of contrast material (ART); and remaining delayed-enhancement (DE(1)-DE(2)) 15 min after administration of 1.25 (DE(1)) and 15 min after additional administration of 2.50 gI/kg (=total 3.75 gI/kg - DE(2)). Mean heart rate decreased to 51+/-9 bpm after intravenous administration of Zatebradine (10 mg/kg). Data sets were reconstructed during the end-diastolic phase of the cardiac cycle. Areas of infarction-enhanced (DE), no-reflow (no-reflow) and remote myocardial [remote left ventricle (LV)] were manually contoured. CT attenuation values (Hounsfield units) were measured using five regions of interest: DE, no-reflow, remote LV, left ventricular cavity (lumen LV) and in air. Differences, correlations, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated.

Results: We found significant differences between the attenuation of DE, no-reflow and remote LV (p<0.001). DE and no-reflow size were assessed accurately with DEMDCT. In particular, SNR and CNR showed higher values in DE(2) (approximately 6.0 and 3.5, respectively; r(2)=0.90) vs. DE(1) (approximately 4.0 and 2.2, respectively; r(2)=0.85).

Conclusions: The increase of contrast material volume determines a significant improvement in myocardial infarction image quality with DE-MDCT.

Titel:	Impact of contrast material volume on quantitative assessment of reperfused acute myocardial infarction using delayed-enhancement 64-slice CT: experience in a porcine model.
Autor/in / Beteiligte Person:	Martini, C ; Maffei, E ; Palumbo, A ; Weustink, A ; Baks, T ; Moelker, A ; Dunker, D ; Emiliano, E ; Cuttone, A ; Mollet, N ; Krestin, G ; De Feyter, P ; Cademartiri, F
Link:	Full Text Finder (Volltext)
Zeitschrift:	La Radiologia medica, Jg. 115 (2010-02-01), Heft 1, S. 22-35
Veröffentlichung:	Milan : Springer Milan ; <i>Original Publication</i>: Torino [etc.] Minerva medica., 2010
Medientyp:	academicJournal
ISSN:	1826-6983 (electronic)
DOI:	10.1007/s11547-009-0481-8
Schlagwort:	Animals Disease Models, Animal Iopamidol administration & dosage Reproducibility of Results Sensitivity and Specificity Sus scrofa Contrast Media administration & dosage Iopamidol analogs & derivatives Myocardial Infarction diagnostic imaging Myocardial Reperfusion Tomography, X-Ray Computed
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article Language: English; Italian [Radiol Med] 2010 Feb; Vol. 115 (1), pp. 22-35. <i>Date of Electronic Publication: </i>2009 Dec 16. MeSH Terms: Myocardial Reperfusion* ; Tomography, X-Ray Computed* ; Contrast Media / administration & dosage ; Iopamidol / analogs & derivatives ; Myocardial Infarction / *diagnostic imaging ; Animals ; Disease Models, Animal ; Iopamidol / administration & dosage ; Reproducibility of Results ; Sensitivity and Specificity ; Sus scrofa References: AJR Am J Roentgenol. 2007 Feb;188(2):W135-7. (PMID: 17242218) ; Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S176-82. (PMID: 7203920) ; Eur Heart J. 2005 Mar;26(6):549-57. (PMID: 15713695) ; Circulation. 1995 Aug 1;92(3):334-41. (PMID: 7634446) ; Circulation. 2006 Jan 24;113(3):394-404. (PMID: 16432071) ; J Am Coll Cardiol. 2006 Jul 4;48(1):144-52. (PMID: 16814660) ; Eur Heart J. 2005 Jun;26(11):1070-7. (PMID: 15716283) ; Radiology. 2008 Oct;249(1):71-80. (PMID: 18796669) ; Eur Radiol. 2007 Feb;17(2):475-83. (PMID: 16802125) ; Circulation. 2002 Aug 27;106(9):1083-9. (PMID: 12196333) ; J Am Coll Cardiol. 2005 Jun 21;45(12):2042-7. (PMID: 15963407) ; Radiol Med. 2007 Dec;112(8):1100-16. (PMID: 18080098) ; J Am Coll Cardiol. 2006 Jan 3;47(1):40-4. (PMID: 16386662) ; Circulation. 1999 Nov 9;100(19):1992-2002. (PMID: 10556226) ; Radiol Med. 2007 Oct;112(7):969-81. (PMID: 17952682) ; AJR Am J Roentgenol. 2004 Jun;182(6):1563-6. (PMID: 15150010) ; Invest Radiol. 2005 Nov;40(11):700-4. (PMID: 16230902) ; Circulation. 1978 Sep;58(3 Pt 1):497-504. (PMID: 679441) ; Med Phys. 2008 Nov;35(11):5054-60. (PMID: 19070239) ; Circulation. 2000 Jun 13;101(23):2734-41. (PMID: 10851212) ; Circulation. 2005 Oct 11;112(15):2318-23. (PMID: 16203914) ; Radiology. 2004 Jun;231(3):697-701. (PMID: 15118118) ; Circulation. 1981 Mar;63(3):597-606. (PMID: 7460246) ; J Am Coll Cardiol. 2005 Aug 2;46(3):552-7. (PMID: 16053973) ; Invest Radiol. 1978 Jul-Aug;13(4):337-9. (PMID: 689828) ; Circulation. 1995 Oct 1;92(7):1902-10. (PMID: 7671375) Substance Nomenclature: 0 (Contrast Media) ; 17E17JBP8L (iomeprol) ; JR13W81H44 (Iopamidol) Entry Date(s): Date Created: 20091218 Date Completed: 20100402 Latest Revision: 20211020 Update Code: 20231215

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Impact of contrast material volume on quantitative assessment of reperfused acute myocardial infarction using delayed-enhancement 64-slice CT: experience in a porcine model.