From randomized trial to practice: single institution experience using the GOG 172 i.p. chemotherapy regimen for ovarian cancer.
In: Annals of oncology : official journal of the European Society for Medical Oncology, Jg. 21 (2010-09-01), Heft 9, S. 1772-1778
Online
academicJournal
Zugriff:
Background: The objective of the study was to evaluate completion rates and toxic effects of an i.p. chemotherapy regimen in a cross-section of nonselected patients with ovarian cancer (OC).
Patients and Methods: All patients with stage IIIC OC consecutively operated at our institution from January 2006 to December 2007 were prospectively collected and analyzed.
Results: Eighty-nine patients with stage IIIC OC optimally debulked were evaluated for this study. An i.p. port was primarily placed in 53 of 89 (60%), and i.p. chemotherapy was recommended in 55 patients. Reasons for not recommending i.p. chemotherapy in patients optimally debulked included postoperative complications (n = 7: 8%), poor nutritional/functional status (n = 5: 6%), and extensive surgery including bowel resection (n = 9: 10%). Thirty-three patients (33/55: 60%) recommended to receive i.p. chemotherapy-initiated i.p. treatment. Fifty-two percent of those beginning i.p. therapy (17/33) received three or more cycles with 36% (12/33) successfully completing six cycles. Reasons for discontinuation included grade 3-4 nephrotoxicity in 3 of 21 (14%), febrile neutropenia/sepsis in 3 of 21 (14%), port infection or malfunction in 8 of 21 (38%).
Conclusions: The i.p. chemotherapy regimen used in a consecutive cohort of patients carries could be completed in only a small percentage of patients. Less toxic regimens with higher acceptability should be considered.
Titel: |
From randomized trial to practice: single institution experience using the GOG 172 i.p. chemotherapy regimen for ovarian cancer.
|
---|---|
Autor/in / Beteiligte Person: | Aletti, GD ; Nordquist, D ; Hartmann, L ; Gallenberg, M ; Long, HJ ; Cliby, WA |
Link: | |
Zeitschrift: | Annals of oncology : official journal of the European Society for Medical Oncology, Jg. 21 (2010-09-01), Heft 9, S. 1772-1778 |
Veröffentlichung: | 2020- : London : Elsevier ; <i>Original Publication</i>: Dordrecht ; Boston : Kluwer Academic Publishers, c1990-, 2010 |
Medientyp: | academicJournal |
ISSN: | 1569-8041 (electronic) |
DOI: | 10.1093/annonc/mdq025 |
Schlagwort: |
|
Sonstiges: |
|