Einzeltreffer — DigiBib

Objective and Design: The present investigation was designed to determine the effects of caffeine on alcohol-induced hepatic injury in mice.

Material: Five groups of mice (8 each) were used.

Treatment: The mice treated with different doses of caffeine (5, 10, and 20 mg/kg, respectively).

Methods: The degree of alcoholic liver injury was evaluated biochemically by measuring serum markers and pathological examination. Real time PCR and ELISA methods were used to check the expression of cytokines and CYP 450.

Results: Treatment with caffeine significantly attenuated the elevated serum aminotransferase enzymes and reduced the severe extent of hepatic cell damage, steatosis and the immigration of inflammatory cells. Interestingly, caffeine decreased hepatic mRNA expression of lipogenic genes, while it had no effect on protein expression of hepatic CYP2E1. Furthermore, caffeine decreased serum and tissue inflammatory cytokines levels, tissue lipid peroxidation and inhibited the necrosis of hepatocytes. Kupffer cells isolated from ethanol-fed mice produced high amounts of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha), whereas Kupffer cells from caffeine treatment mice produced less ROS and TNF-alpha.

Conclusions: These findings suggest that caffeine may represent a novel, protective strategy against alcoholic liver injury by attenuating oxidative stress and inflammatory response.

Titel:	Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress.
Autor/in / Beteiligte Person:	Lv, X ; Chen, Z ; Li, J ; Zhang, L ; Liu, H ; Huang, C ; Zhu, P
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammation research : official journal of the European Histamine Research Society ... [et al.], Jg. 59 (2010-08-01), Heft 8, S. 635-45
Veröffentlichung:	Basel, Switzerland : Birkhäuser, c1995-, 2010
Medientyp:	academicJournal
ISSN:	1420-908X (electronic)
DOI:	10.1007/s00011-010-0176-6
Schlagwort:	Animals Cells, Cultured Chemokines metabolism Cytochrome P-450 CYP2E1 metabolism Cytokines metabolism Ethanol pharmacology Kupffer Cells cytology Kupffer Cells metabolism Lipid Peroxidation drug effects Liver cytology Liver metabolism Male Malondialdehyde metabolism Mice Reactive Oxygen Species metabolism Tumor Necrosis Factor-alpha metabolism Caffeine pharmacology Central Nervous System Stimulants pharmacology Inflammation metabolism Liver drug effects Liver pathology Oxidative Stress drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Inflamm Res] 2010 Aug; Vol. 59 (8), pp. 635-45. <i>Date of Electronic Publication: </i>2010 Mar 10. MeSH Terms: Caffeine / pharmacology ; Central Nervous System Stimulants / pharmacology ; Inflammation / metabolism ; Liver / drug effects ; Liver / pathology ; Oxidative Stress / drug effects ; Animals ; Cells, Cultured ; Chemokines / metabolism ; Cytochrome P-450 CYP2E1 / metabolism ; Cytokines / metabolism ; Ethanol / pharmacology ; Kupffer Cells / cytology ; Kupffer Cells / metabolism ; Lipid Peroxidation / drug effects ; Liver / cytology ; Liver / metabolism ; Male ; Malondialdehyde / metabolism ; Mice ; Reactive Oxygen Species / metabolism ; Tumor Necrosis Factor-alpha / metabolism References: Alcohol Clin Exp Res. 1989 Feb;13(1):15-9. (PMID: 2646971) ; Hepatology. 2010 Jan;51(1):307-28. (PMID: 20034030) ; N Engl J Med. 2009 Jun 25;360(26):2758-69. (PMID: 19553649) ; Gastroenterology. 2005 Dec;129(6):1928-36. (PMID: 16344061) ; Gastroenterology. 2005 Jun;128(7):2066-76. (PMID: 15940638) ; Proc Nutr Soc. 2006 Aug;65(3):278-90. (PMID: 16923312) ; Trends Mol Med. 2008 Feb;14(2):63-71. (PMID: 18222109) ; Exp Biol Med (Maywood). 2003 Sep;228(8):882-90. (PMID: 12968059) ; Int J Radiat Biol. 2000 Sep;76(9):1281-8. (PMID: 10993639) ; Food Chem Toxicol. 2007 Nov;45(11):2118-25. (PMID: 17590492) ; Hepatology. 2008 Jul;48(1):129-36. (PMID: 18537182) ; Exp Anim. 2008 Oct;57(5):461-9. (PMID: 18946183) ; Gastroenterology. 2007 May;132(5):1740-5. (PMID: 17484871) ; J Pharm Pharmacol. 2008 Sep;60(9):1161-5. (PMID: 18718119) ; J Pharm Pharmacol. 2009 Apr;61(4):473-8. (PMID: 19298694) ; Mol Pharmacol. 1995 Nov;48(5):825-34. (PMID: 7476912) ; J Hepatol. 2008 Nov;49(5):758-67. (PMID: 18486259) ; Aliment Pharmacol Ther. 2007 Jul 1;26(1):1-8. (PMID: 17555416) ; Ann Neurol. 2006 Dec;60(6):696-705. (PMID: 17044013) ; Gastroenterology. 1999 Oct;117(4):942-52. (PMID: 10500078) ; Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1746-53. (PMID: 19505908) ; Ann Intern Med. 1990 Jun 15;112(12):917-20. (PMID: 2339855) ; Int J Cancer. 2005 Aug 10;116(1):150-4. (PMID: 15756689) ; Alcohol Clin Exp Res. 2009 Oct;33(10):1647-55. (PMID: 19645734) ; Gastroenterology. 2003 Mar;124(3):778-90. (PMID: 12612915) ; Semin Liver Dis. 2009 May;29(2):141-54. (PMID: 19387914) ; J Immunol. 2001 Apr 1;166(7):4737-42. (PMID: 11254735) ; Food Chem Toxicol. 2009 Mar;47(3):530-5. (PMID: 19133309) ; Alcohol. 2002 May;27(1):63-8. (PMID: 12062639) ; Gastroenterology. 2005 Jan;128(1):24-32. (PMID: 15633120) ; Hepatology. 2004 Aug;40(2):442-51. (PMID: 15368449) ; Methods Mol Biol. 2008;447:185-97. (PMID: 18369920) ; Hepatology. 2009 Aug;50(2):638-44. (PMID: 19575462) ; J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S98-103. (PMID: 18336675) ; Hepatology. 2006 Feb;43(2 Suppl 1):S63-74. (PMID: 16447273) ; Hepatology. 2008 Oct;48(4):1224-31. (PMID: 18792393) ; J Clin Epidemiol. 2001 Aug;54(8):823-9. (PMID: 11470392) ; Alcohol Clin Exp Res. 2002 May;26(5):731-6. (PMID: 12045483) ; J Oleo Sci. 2008;57(12):691-7. (PMID: 19001782) ; Gastroenterology. 1999 Jul;117(1):181-90. (PMID: 10381926) ; Gastroenterology. 2003 May;124(5):1488-99. (PMID: 12730887) ; Free Radic Biol Med. 2008 Mar 1;44(5):723-38. (PMID: 18078827) ; Int J Epidemiol. 1998 Jun;27(3):438-43. (PMID: 9698132) ; Am J Gastroenterol. 2010 Jan;105(1):14-32; quiz 33. (PMID: 19904248) ; Hepatology. 2010 Jan;51(1):201-9. (PMID: 20034049) ; Alcohol. 2002 May;27(1):13-5. (PMID: 12062631) ; Curr Opin Immunol. 2004 Oct;16(5):538-44. (PMID: 15341996) ; Hepatology. 2006 Sep;44(3):521-6. (PMID: 16941687) ; J Immunol. 2002 Mar 15;168(6):2963-9. (PMID: 11884468) ; Nat Immunol. 2001 Aug;2(8):675-80. (PMID: 11477402) ; Hepatology. 2001 Nov;34(5):935-42. (PMID: 11679964) ; Food Chem Toxicol. 1996 Jan;34(1):119-29. (PMID: 8603790) ; Liver Int. 2009 Jul;29(6):886-97. (PMID: 19291178) ; J Hepatol. 2005 Apr;42(4):444-6. (PMID: 15763323) Substance Nomenclature: 0 (Central Nervous System Stimulants) ; 0 (Chemokines) ; 0 (Cytokines) ; 0 (Reactive Oxygen Species) ; 0 (Tumor Necrosis Factor-alpha) ; 3G6A5W338E (Caffeine) ; 3K9958V90M (Ethanol) ; 4Y8F71G49Q (Malondialdehyde) ; EC 1.14.13.- (Cytochrome P-450 CYP2E1) Entry Date(s): Date Created: 20100312 Date Completed: 20101115 Latest Revision: 20220409 Update Code: 20231215

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Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress.