Einzeltreffer — DigiBib

Purpose: Evaluation of the dose distribution for lung cancer patients using a patient setup procedure based on the bony anatomy or the primary tumor.

Methods and Materials: For 39 patients with non-small-cell lung cancer, the planning fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan was registered to a repeated FDG-PET/CT scan made in the second week of treatment. Two patient setup methods were analyzed based on the bony anatomy or the primary tumor. The original treatment plan was copied to the repeated scan, and target and normal tissue structures were delineated. Dose distributions were analyzed using dose-volume histograms for the primary tumor, lymph nodes, lungs, and spinal cord.

Results: One patient showed decreased dose coverage of the primary tumor caused by progressive disease and required replanning to achieve adequate coverage. For the other patients, the minimum dose to the primary tumor did not significantly deviate from the planned dose: -0.2 ± 1.7% (p = 0.71) and -0.1 ± 1.7% (p = 0.85) for the bony anatomy setup and the primary tumor setup, respectively. For patients (n = 31) with nodal involvement, 10% showed a decrease in minimum dose larger than 5% for the bony anatomy setup and 13% for the primary tumor setup. The mean lung dose exceeded the maximum allowed 20 Gy in 21% of the patients for the bony anatomy setup and in 13% for the primary tumor setup, whereas for the spinal cord this occurred in 10% and 13% of the patients, respectively.

Conclusions: In 10% and 13% of patients with nodal involvement, setup based on bony anatomy or primary tumor, respectively, led to important dose deviations in nodal target volumes. Overdosage of critical structures occurred in 10-20% of the patients. In cases of progressive disease, repeated imaging revealed underdosage of the primary tumor. Development of practical ways for setup procedures based on repeated high-quality imaging of all tumor sites during radiotherapy should therefore be an important research focus.

Titel:	Should patient setup in lung cancer be based on the primary tumor? An analysis of tumor coverage and normal tissue dose using repeated positron emission tomography/computed tomography imaging.
Autor/in / Beteiligte Person:	van Elmpt W ; Öllers, M ; Lambin, P ; De Ruysscher, D
Zeitschrift:	International journal of radiation oncology, biology, physics, Jg. 82 (2012), Heft 1, S. 379-85
Veröffentlichung:	New York, NY : Elsevier, Inc ; <i>Original Publication</i>: Elmsford, N. Y., Pergamon Press., 2012
Medientyp:	academicJournal
ISSN:	1879-355X (electronic)
DOI:	10.1016/j.ijrobp.2010.09.016
Schlagwort:	Aged Aged, 80 and over Bone and Bones diagnostic imaging Carcinoma, Non-Small-Cell Lung drug therapy Carcinoma, Non-Small-Cell Lung radiotherapy Disease Progression Female Fluorodeoxyglucose F18 Humans Induction Chemotherapy methods Lung diagnostic imaging Lung Neoplasms drug therapy Lung Neoplasms radiotherapy Lymph Nodes diagnostic imaging Male Mediastinum diagnostic imaging Middle Aged Prospective Studies Radiopharmaceuticals Radiotherapy Dosage Small Cell Lung Carcinoma drug therapy Small Cell Lung Carcinoma radiotherapy Spinal Cord diagnostic imaging Tumor Burden Anatomic Landmarks diagnostic imaging Carcinoma, Non-Small-Cell Lung diagnostic imaging Lung Neoplasms diagnostic imaging Multimodal Imaging methods Organs at Risk diagnostic imaging Positron-Emission Tomography Radiotherapy Planning, Computer-Assisted methods Small Cell Lung Carcinoma diagnostic imaging Tomography, X-Ray Computed
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Radiat Oncol Biol Phys] 2012 Jan 01; Vol. 82 (1), pp. 379-85. <i>Date of Electronic Publication: </i>2010 Nov 17. MeSH Terms: Positron-Emission Tomography* ; Tomography, X-Ray Computed* ; Anatomic Landmarks / diagnostic imaging ; Carcinoma, Non-Small-Cell Lung / diagnostic imaging ; Lung Neoplasms / diagnostic imaging ; Multimodal Imaging / methods ; Organs at Risk / diagnostic imaging ; Radiotherapy Planning, Computer-Assisted / methods ; Small Cell Lung Carcinoma / *diagnostic imaging ; Aged ; Aged, 80 and over ; Bone and Bones / diagnostic imaging ; Carcinoma, Non-Small-Cell Lung / drug therapy ; Carcinoma, Non-Small-Cell Lung / radiotherapy ; Disease Progression ; Female ; Fluorodeoxyglucose F18 ; Humans ; Induction Chemotherapy / methods ; Lung / diagnostic imaging ; Lung Neoplasms / drug therapy ; Lung Neoplasms / radiotherapy ; Lymph Nodes / diagnostic imaging ; Male ; Mediastinum / diagnostic imaging ; Middle Aged ; Prospective Studies ; Radiopharmaceuticals ; Radiotherapy Dosage ; Small Cell Lung Carcinoma / drug therapy ; Small Cell Lung Carcinoma / radiotherapy ; Spinal Cord / diagnostic imaging ; Tumor Burden References: Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):771-8. (PMID: 17398018) ; Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1394-401. (PMID: 18258380) ; J Clin Oncol. 2010 Mar 10;28(8):1380-6. (PMID: 20142596) ; Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):329-36. (PMID: 19782478) ; Int J Radiat Oncol Biol Phys. 2009 Jun 1;74(2):341-8. (PMID: 19038504) ; Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1548-58. (PMID: 17394950) ; Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1221-8. (PMID: 16442240) ; Int J Radiat Oncol Biol Phys. 1999 Mar 1;43(4):905-19. (PMID: 10098447) ; Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):988-94. (PMID: 15989999) ; Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):89-95. (PMID: 20421149) ; Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):126-34. (PMID: 16904518) ; Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):590-8. (PMID: 18037579) ; Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):1103-10. (PMID: 18258382) ; Semin Radiat Oncol. 2010 Apr;20(2):94-106. (PMID: 20219547) ; Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1092-9. (PMID: 19095370) ; Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):1121-35. (PMID: 10863086) ; Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):139-44. (PMID: 17996384) ; Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):435-48. (PMID: 16198064) ; Semin Radiat Oncol. 2007 Oct;17(4):258-67. (PMID: 17903703) ; Radiother Oncol. 2008 Jan;86(1):25-9. (PMID: 18023488) ; Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):135-41. (PMID: 16839704) ; Int J Radiat Oncol Biol Phys. 2005 Nov 15;63(4):1024-8. (PMID: 16005575) ; Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):748-53. (PMID: 17011450) Grant Information: U01 CA143062 United States CA NCI NIH HHS Substance Nomenclature: 0 (Radiopharmaceuticals) ; 0Z5B2CJX4D (Fluorodeoxyglucose F18) Entry Date(s): Date Created: 20101125 Date Completed: 20120319 Latest Revision: 20211020 Update Code: 20240513 PubMed Central ID: PMC4693613

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Should patient setup in lung cancer be based on the primary tumor? An analysis of tumor coverage and normal tissue dose using repeated positron emission tomography/computed tomography imaging.