A measurement setup for direct 17O MRI at 7 T.
In: Magnetic resonance in medicine, Jg. 66 (2011-10-01), Heft 4, S. 1109-15
Online
academicJournal
Zugriff:
An efficient breathing system was designed for direct (17)O MRI to perform oxygen metabolism studies of the human brain. The breathing system consists of a demand oxygen delivery device for (17)O(2) supply and a custom-built re-breathing circuit with pneumatic switching valve. To efficiently deliver the (17)O gas to the alveoli of the lungs, the system applies short gas pulses upon an inspiration trigger via a nasal cannula. During and after (17)O(2) administration, the exhaled gas volumes are stored and filtered in the re-breathing section to make the most efficient use of the rare (17)O gas. In an inhalation experiment, 2.2 ± 0.1 L of 70%-enriched (17)O(2) were administered to a healthy volunteer and direct (17)O MRI was performed for a total imaging time of 38 min with a temporal resolution of 50 s per 3D data set. Mapping of the maximum signal increase was carried out showing regional variations of oxygen concentration of up to 30% over the natural abundance of (17)O water.
(Copyright © 2011 Wiley-Liss, Inc.)
| Titel: |
A measurement setup for direct 17O MRI at 7 T.
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| Autor/in / Beteiligte Person: | Hoffmann, SH ; Begovatz, P ; Nagel, AM ; Umathum, R ; Schommer, K ; Bachert, P ; Bock, M |
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| Zeitschrift: | Magnetic resonance in medicine, Jg. 66 (2011-10-01), Heft 4, S. 1109-15 |
| Veröffentlichung: | 1999- : New York, NY : Wiley ; <i>Original Publication</i>: San Diego : Academic Press,, 2011 |
| Medientyp: | academicJournal |
| ISSN: | 1522-2594 (electronic) |
| DOI: | 10.1002/mrm.22871 |
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