Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.
In: Nutrition and cancer, Jg. 64 (2012), Heft 1, S. 57-64
academicJournal
Zugriff:
γ-Tocopherol (γT) protects against DNA-damaging effects of nitrogen oxides, yet its physiologic regulation in vivo is unknown. Observational studies indicate inverse associations of 25[OH]-vitamin D with γT and leptin. To determine whether vitamin D(3) supplementation alters levels of lipid-soluble micronutrients, serum samples (N = 85 subjects) from a randomized, double-blind, placebo-controlled clinical trial of vitamin D(3) (800 IU) and calcium (2 g), alone and in combination, were analyzed for lipid micronutrients and specific vitamin D metabolites at baseline and after 6 mo of supplementation. Serum 25[OH]-vitamin D(3) levels increased 55% (P < 0.0001) and 48% (P = 0.0005), whereas 25[OH]-vitamin D(2) levels were lower by 48% (P = 0.26) and 21% (P = 0.36) in the vitamin D(3) and vitamin D(3) plus calcium groups, respectively. At baseline, γT levels were inversely associated with 25[OH]D (r = -0.31, P = 0.004). With vitamin D(3) plus calcium treatment, serum α-tocopherol decreased 14% (P = 0.04), whereas similar changes in γT (19% lower, P = 0.14) were observed. No significant effects were observed for D(3) supplementation on leptin or retinol levels. These results are consistent with the hypothesis that vitamin D(3) ± calcium affects serum tocopherol and 25[OH]D(2) levels; however, studies using larger, more homogeneous populations are warranted.
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Effects of vitamin D3 and calcium supplementation on serum levels of tocopherols, retinol, and specific vitamin D metabolites.
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Autor/in / Beteiligte Person: | Chai, W ; Bostick, RM ; Ahearn, TU ; Franke, AA ; Custer, LJ ; Cooney, RV |
Zeitschrift: | Nutrition and cancer, Jg. 64 (2012), Heft 1, S. 57-64 |
Veröffentlichung: | Philadelphia : Routledge ; <i>Original Publication</i>: Philadelphia, Franklin Institute Press., 2012 |
Medientyp: | academicJournal |
ISSN: | 1532-7914 (electronic) |
DOI: | 10.1080/01635581.2012.630552 |
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