Determination of infarct size in ex vivo swine hearts by multidetector computed tomography using gadolinium as contrast medium.
In: Investigative radiology, Jg. 47 (2012-05-01), Heft 5, S. 277-83
Online
academicJournal
Zugriff:
Objective: To demonstrate the feasibility of using multidetector computed tomography with gadolinium contrast (Gd-MDCT) for the quantification of myocardial infarct (MI).
Materials and Methods: MI was induced in male swine (n = 6). One week later, the animals received 0.2-mmol/kg gadopentetate dimeglumine and were sacrificed. On the excised hearts, Gd-MDCT with several tube voltages (80, 120, and 140 kV), late gadolinium enhancement MRI (LGE-MRI), and triphenyl-tetrazolium-chloride staining were then conducted. We used a 2-SD threshold for the CT images and several threshold limits (2, 3, 4, 5, 6 SD, and full width at half-maximum [FWHM]) for the LGE-MRI images to delineate the infarct area. Total infarct volume and infarct fraction of each heart were calculated.
Results: MI size measured by MDCT at 140 kV showed good correlation with the reference triphenyl-tetrazolium-chloride value. Applying an 80-kV tube voltage, however, significantly underestimated MI size. In our study, the LGE-MRI method, using the 6-SD threshold, provided the most accurate determination of MI size. LGE-MRI, using the 2- and 3-SD threshold limits, significantly overestimated infarct size.
Conclusions: The Gd-MDCT technique has been found suitable for the evaluation of MI in an ex vivo experimental setting. Gd-MDCT has the ability to detect MI even at low kV settings, but accuracy is limited by a high image noise because of reduced photon flux.
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Determination of infarct size in ex vivo swine hearts by multidetector computed tomography using gadolinium as contrast medium.
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Autor/in / Beteiligte Person: | Varga-Szemes, A ; Ruzsics, B ; Kirschner, R ; Singh, SP ; Kiss, P ; Brott, BC ; Simor, T ; Elgavish, A ; Elgavish, GA |
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Zeitschrift: | Investigative radiology, Jg. 47 (2012-05-01), Heft 5, S. 277-83 |
Veröffentlichung: | 1998- : Hagerstown, MD : Lippincott Williams & Wilkins ; <i>Original Publication</i>: Philadelphia., 2012 |
Medientyp: | academicJournal |
ISSN: | 1536-0210 (electronic) |
DOI: | 10.1097/RLI.0b013e31823fabc6 |
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