Intake of vitamins D and A and calcium and risk of non-Hodgkin lymphoma: San Francisco Bay Area population-based case-control study.
In: Nutrition and cancer, Jg. 64 (2012), Heft 5, S. 674-84
academicJournal
Zugriff:
Several nutrients identified as potentially cancer protective have been inconsistently associated with non-Hodgkin lymphoma (NHL) risk. Dietary history data, including use of vitamin supplements, were collected using a semiquantitative food frequency questionnaire administered during in-person interviews with 4,133 participants (2,052 cases, 2,081 controls) in a San Francisco Bay Area population-based case-control study. Data were used to determine the association of intake levels of vitamins D and A and calcium with risk of NHL and NHL subtypes. Odds ratios (OR) and 95% confidence intervals (CI) were computed as estimates of relative risk using adjusted unconditional logistic regression. Increasing vitamin D intake from food and supplements was positively associated with NHL risk in men (5th quintile: OR = 1.6, 95% CI = 1.0-2.4, P(trend) = 0.07) and with diffuse large B-cell lymphoma (DLBCL) in women and men (5th quintile: OR = 1.6, 95% CI = 1.0-2.5, P(trend) = 0.02); that was largely due to the effect in men (P(trend) = 0.03). These results do not support a strong role for vitamin D intake with NHL risk, with the exception of a potential association for DLBCL risk in men. Our results should be interpreted conservatively until further investigation in larger pooled studies can be conducted to better assess the role of vitamin D intake in lymphomagenesis.
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Intake of vitamins D and A and calcium and risk of non-Hodgkin lymphoma: San Francisco Bay Area population-based case-control study.
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Autor/in / Beteiligte Person: | Mikhak, B ; Bracci, PM ; Gong, Z |
Zeitschrift: | Nutrition and cancer, Jg. 64 (2012), Heft 5, S. 674-84 |
Veröffentlichung: | Philadelphia : Routledge ; <i>Original Publication</i>: Philadelphia, Franklin Institute Press., 2012 |
Medientyp: | academicJournal |
ISSN: | 1532-7914 (electronic) |
DOI: | 10.1080/01635581.2012.689916 |
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