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Background: Although several reports have described a possible association between DNA repair genes and pancreatic cancer (PC) in smokers, this association has not been fully evaluated in an Asian population. We assessed the impact of genetic polymorphisms in the base excision repair (BER) pathway on PC risk among Japanese.

Methods: This case-control study compared the frequency of 5 single-nucleotide polymorphisms (SNPs) of BER genes, namely rs1052133 in OGG1, rs1799782 and rs25487 in XRCC1, rs1130409 in APE1, and rs1136410 in PARP1. SNPs were investigated using the TaqMan assay in 185 PC cases and 1465 controls. Associations of PC risk with genetic polymorphisms and gene-environment interaction were examined with an unconditional logistic regression model. Exposure to risk factors was assessed from the results of a self-administered questionnaire. We also performed haplotype-based analysis.

Results: We observed that the minor allele of rs25487 in XRCC1 was significantly associated with PC risk in the per-allele model (odds ratio = 1.29, CI = 1.01-1.65; trend P = 0.043). Haplotype analysis of XRCC1 also showed a statistically significant association with PC risk. No statistically significant interaction between XRCC1 polymorphisms and smoking status was seen.

Conclusions: Our findings suggest that XRCC1 polymorphisms affect PC risk in Japanese.

Titel:	Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese.
Autor/in / Beteiligte Person:	Nakao, M ; Hosono, S ; Ito, H ; Watanabe, M ; Mizuno, N ; Sato, S ; Yatabe, Y ; Yamao, K ; Ueda, R ; Tajima, K ; Tanaka, H ; Matsuo, K
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of epidemiology, Jg. 22 (2012), Heft 6, S. 477-83
Veröffentlichung:	2018- : [Tokyo] : Japan Epidemiological Association ; <i>Original Publication</i>: Tokyo : Japan Epidemiological Association, 2012
Medientyp:	academicJournal
ISSN:	1349-9092 (electronic)
DOI:	10.2188/jea.JE20120010
Schlagwort:	Adult Aged Asian People statistics & numerical data Case-Control Studies DNA Glycosylases genetics DNA-(Apurinic or Apyrimidinic Site) Lyase genetics Female Gene Frequency Gene-Environment Interaction Humans Japan Male Middle Aged Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases genetics Risk Factors Smoking ethnology Smoking genetics X-ray Repair Cross Complementing Protein 1 Asian People genetics DNA Repair genetics DNA-Binding Proteins genetics Genetic Predisposition to Disease ethnology Pancreatic Neoplasms ethnology Pancreatic Neoplasms genetics Polymorphism, Single Nucleotide genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Epidemiol] 2012; Vol. 22 (6), pp. 477-83. <i>Date of Electronic Publication: </i>2012 Jul 28. MeSH Terms: Asian People / genetics ; DNA Repair / genetics ; DNA-Binding Proteins / genetics ; Genetic Predisposition to Disease / ethnology ; Pancreatic Neoplasms / ethnology ; Pancreatic Neoplasms / genetics ; Polymorphism, Single Nucleotide / *genetics ; Adult ; Aged ; Asian People / statistics & numerical data ; Case-Control Studies ; DNA Glycosylases / genetics ; DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics ; Female ; Gene Frequency ; Gene-Environment Interaction ; Humans ; Japan ; Male ; Middle Aged ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases / genetics ; Risk Factors ; Smoking / ethnology ; Smoking / genetics ; X-ray Repair Cross Complementing Protein 1 References: Asian Pac J Cancer Prev. 2010;11(6):1601-4. (PMID: 21338203) ; Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):197-209. (PMID: 16549324) ; J Clin Epidemiol. 1997 Jan;50(1):69-77. (PMID: 9048692) ; Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1470-9. (PMID: 18559563) ; Int J Cancer. 2007 May 1;120(9):1993-8. (PMID: 17266034) ; Am J Epidemiol. 2005 Nov 15;162(10):925-42. (PMID: 16221808) ; Jpn J Clin Oncol. 2009 Dec;39(12):850-8. (PMID: 19797417) ; Cancer Lett. 2007 Jan 8;245(1-2):61-8. (PMID: 16458430) ; Blood. 2006 Nov 1;108(9):3161-7. (PMID: 16857995) ; Asian Pac J Cancer Prev. 2000;1(1):35-47. (PMID: 12718687) ; Cancer Res. 2002 Aug 15;62(16):4630-6. (PMID: 12183419) ; Jpn J Clin Oncol. 2006 Sep;36(9):602-7. (PMID: 16870692) ; Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1295-302. (PMID: 19318433) ; Cancer Res. 1998 Feb 15;58(4):604-8. (PMID: 9485007) ; Int J Cancer. 2007 Jun 15;120(12):2665-71. (PMID: 17304505) ; Cancer Detect Prev. 2006;30(3):284-91. (PMID: 16844323) ; Cancer Causes Control. 2008 Dec;19(10):1233-42. (PMID: 18618280) ; Cancer Res. 2008 Jun 15;68(12):4928-35. (PMID: 18544627) ; Am J Hum Genet. 2003 Dec;73(6):1316-29. (PMID: 14631556) ; Clin Cancer Res. 2009 Jan 15;15(2):740-6. (PMID: 19147782) ; Nat Rev Genet. 2008 Aug;9(8):619-31. (PMID: 18626472) ; Cancer Sci. 2009 Feb;100(2):296-302. (PMID: 19068087) ; Adv Surg. 2010;44:293-311. (PMID: 20919528) ; Cancer Sci. 2010 May;101(5):1073-9. (PMID: 20345478) ; Asian Pac J Cancer Prev. 2001;2(2):99-107. (PMID: 12718640) ; Carcinogenesis. 2000 May;21(5):965-71. (PMID: 10783319) ; Carcinogenesis. 2009 Jan;30(1):2-10. (PMID: 18978338) ; Int J Epidemiol. 2003 Apr;32(2):257-62. (PMID: 12714546) ; Cancer Sci. 2011 May;102(5):1076-80. (PMID: 21306478) ; PLoS One. 2010 Jul 29;5(7):e11824. (PMID: 20686608) ; Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):84-91. (PMID: 17220334) ; J Epidemiol. 2011;21(1):2-12. (PMID: 21071884) ; J Oral Pathol Med. 2006 Jan;35(1):11-8. (PMID: 16393248) Substance Nomenclature: 0 (DNA-Binding Proteins) ; 0 (X-ray Repair Cross Complementing Protein 1) ; 0 (XRCC1 protein, human) ; EC 2.4.2.30 (PARP1 protein, human) ; EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1) ; EC 2.4.2.30 (Poly(ADP-ribose) Polymerases) ; EC 3.2.2.- (DNA Glycosylases) ; EC 3.2.2.- (oxoguanine glycosylase 1, human) ; EC 4.2.99.18 (APEX1 protein, human) ; EC 4.2.99.18 (DNA-(Apurinic or Apyrimidinic Site) Lyase) Entry Date(s): Date Created: 20120802 Date Completed: 20130130 Latest Revision: 20221207 Update Code: 20231215 PubMed Central ID: PMC3798558

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Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese.