Einzeltreffer — DigiBib

The cerebral metabolic rate of oxygen of small animals can be reliably imaged using the in vivo (17) O magnetic resonance approach at high field. However, a separate measurement is required for imaging the cerebral blood flow in the same animal. In this study, we demonstrate that the (17) O NMR signal of metabolically produced H2 (17) O in the rat brain following an (17) O2 inhalation can serve as a perfusion tracer and its decay rate can be used to determine the absolute values of cerebral blood flow across a wide range of animal conditions. This finding suggests that the in vivo (17) O magnetic resonance approach is capable of imaging both cerebral metabolic rate of oxygen and cerebral blood flow simultaneously and noninvasively; and it provides new utilities for studying the cerebral oxygen metabolism and perfusion commonly associated with brain function and diseases.

Titel:	In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer.
Autor/in / Beteiligte Person:	Zhu, XH ; Zhang, Y ; Wiesner, HM ; Ugurbil, K ; Chen, W
Link:	Full Text Finder (Volltext)
Zeitschrift:	Magnetic resonance in medicine, Jg. 70 (2013-08-01), Heft 2, S. 309-14
Veröffentlichung:	1999- : New York, NY : Wiley ; <i>Original Publication</i>: San Diego : Academic Press,, 2013
Medientyp:	academicJournal
ISSN:	1522-2594 (electronic)
DOI:	10.1002/mrm.24469
Schlagwort:	Animals Blood Flow Velocity physiology Male Oxygen Isotopes pharmacokinetics Radiopharmaceuticals pharmacokinetics Rats Rats, Sprague-Dawley Brain physiology Cerebrovascular Circulation physiology Magnetic Resonance Spectroscopy methods Oximetry methods Oxygen blood Oxygen Consumption physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Magn Reson Med] 2013 Aug; Vol. 70 (2), pp. 309-14. <i>Date of Electronic Publication: </i>2012 Sep 21. MeSH Terms: Brain / physiology ; Cerebrovascular Circulation / physiology ; Magnetic Resonance Spectroscopy / methods ; Oximetry / methods ; Oxygen / blood ; Oxygen Consumption / physiology ; Animals ; Blood Flow Velocity / physiology ; Male ; Oxygen Isotopes / pharmacokinetics ; Radiopharmaceuticals / pharmacokinetics ; Rats ; Rats, Sprague-Dawley References: Adv Exp Med Biol. 2011;701:215-22. (PMID: 21445790) ; Neuroimage. 2010 Jun;51(2):723-33. (PMID: 20188194) ; Neurol Res. 1993 Feb;15(1):7-22. (PMID: 8098859) ; J Theor Biol. 1994 Sep 7;170(1):1-14. (PMID: 7967632) ; Neurol Res. 1992 Sep;14(4):303-11. (PMID: 1360624) ; Magn Reson Med. 1990 May;14(2):266-82. (PMID: 2345507) ; Adv Exp Med Biol. 1997;411:585-90. (PMID: 9269476) ; J Cereb Blood Flow Metab. 1995 Mar;15(2):312-20. (PMID: 7860664) ; Magn Reson Med. 1991 Oct;21(2):313-9. (PMID: 1745131) ; Stroke. 1979 May-Jun;10(3):267-72. (PMID: 37614) ; Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13194-9. (PMID: 12242341) ; NMR Biomed. 2005 Apr;18(2):83-103. (PMID: 15770611) ; Br J Radiol. 2006 Aug;79(944):688-701. (PMID: 16861326) ; J Cereb Blood Flow Metab. 1985 Mar;5(1):65-9. (PMID: 3871783) ; Biochem Biophys Res Commun. 1990 May 31;169(1):153-8. (PMID: 2350339) ; Magn Reson Med. 2001 Apr;45(4):543-9. (PMID: 11283979) ; Magn Reson Med. 1991 Jun;19(2):299-304. (PMID: 1881319) ; J Cereb Blood Flow Metab. 2009 Jan;29(1):10-8. (PMID: 18781163) ; Keio J Med. 1994 Mar;43(1):9-14. (PMID: 8189681) ; Curr Opin Anaesthesiol. 2006 Oct;19(5):473-80. (PMID: 16960477) ; Biochem Biophys Res Commun. 1991 Sep 16;179(2):954-61. (PMID: 1898415) ; Adv Exp Med Biol. 2003;510:213-8. (PMID: 12580430) ; J Cereb Blood Flow Metab. 2004 Aug;24(8):840-8. (PMID: 15362714) ; J Magn Reson. 2008 Jul;193(1):63-7. (PMID: 18456525) ; Cerebrovasc Dis. 2011;32(4):307-20. (PMID: 21921593) ; Magn Reson Med. 1992 Apr;24(2):370-4. (PMID: 1569875) ; Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14409-14. (PMID: 14612566) ; J Cereb Blood Flow Metab. 2007 Jun;27(6):1225-34. (PMID: 17133228) ; Biochemistry. 1986 Nov 18;25(23):7667-75. (PMID: 3026457) ; Curr Opin Neurol. 2009 Aug;22(4):348-55. (PMID: 19491678) ; Adv Exp Med Biol. 2011;701:193-9. (PMID: 21445787) Grant Information: R01 NS057560 United States NS NINDS NIH HHS; P41 RR008079 United States RR NCRR NIH HHS; NS041262S1 United States NS NINDS NIH HHS; NS041262 United States NS NINDS NIH HHS; P30 NS076408 United States NS NINDS NIH HHS; R01 NS070839 United States NS NINDS NIH HHS; NS057560 United States NS NINDS NIH HHS; P30 NS057091 United States NS NINDS NIH HHS; NS070839 United States NS NINDS NIH HHS; P41 EB015894 United States EB NIBIB NIH HHS; P41 RR08079 United States RR NCRR NIH HHS; NS070839S1 United States NS NINDS NIH HHS; R01 NS041262 United States NS NINDS NIH HHS Contributed Indexing: Keywords: brain; cerebral blood flow; cerebral metabolic rate of oxygen; in vivo 17O NMR; perfusion tracer Substance Nomenclature: 0 (Oxygen Isotopes) ; 0 (Radiopharmaceuticals) ; S88TT14065 (Oxygen) Entry Date(s): Date Created: 20120925 Date Completed: 20140225 Latest Revision: 20211021 Update Code: 20240513 PubMed Central ID: PMC3529985

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer.