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Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during male germ cell differentiation, including the switch from transit amplifying progenitor to spermatocyte growth and differentiation, as well as meiotic cell cycle progression and spermiogenesis. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages.

Titel:	The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.
Autor/in / Beteiligte Person:	Davies, EL ; Lim, JG ; Joo, WJ ; Tam, CH ; Fuller, MT
Link:	Full Text Finder (Volltext)
Zeitschrift:	Developmental biology, Jg. 373 (2013-01-15), Heft 2, S. 310-21
Veröffentlichung:	San Diego, CA : Elsevier ; <i>Original Publication</i>: New York., 2013
Medientyp:	academicJournal
ISSN:	1095-564X (electronic)
DOI:	10.1016/j.ydbio.2012.11.004
Schlagwort:	Animals Cell Division Cell Lineage genetics Drosophila Proteins genetics Gene Expression Regulation, Developmental Gene Knockdown Techniques Janus Kinases metabolism Male Meiosis Mutation genetics Nuclear Proteins genetics Nuclear Proteins metabolism Protein Isoforms genetics Protein Isoforms metabolism RNA Interference STAT Transcription Factors metabolism Signal Transduction Spermatogenesis genetics Spermatogonia cytology Spermatogonia metabolism Spermatozoa metabolism Stem Cells metabolism Transcription Factors genetics Transforming Growth Factor beta metabolism Cell Differentiation genetics Drosophila Proteins metabolism Drosophila melanogaster cytology Drosophila melanogaster genetics Spermatozoa cytology Stem Cells cytology Testis cytology Transcription Factors metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Language: English [Dev Biol] 2013 Jan 15; Vol. 373 (2), pp. 310-21. <i>Date of Electronic Publication: </i>2012 Nov 15. MeSH Terms: Cell Differentiation* / genetics ; Drosophila Proteins / metabolism ; Drosophila melanogaster / cytology ; Drosophila melanogaster / genetics ; Spermatozoa / cytology ; Stem Cells / cytology ; Testis / cytology ; Transcription Factors / *metabolism ; Animals ; Cell Division ; Cell Lineage / genetics ; Drosophila Proteins / genetics ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Janus Kinases / metabolism ; Male ; Meiosis ; Mutation / genetics ; Nuclear Proteins / genetics ; Nuclear Proteins / metabolism ; Protein Isoforms / genetics ; Protein Isoforms / metabolism ; RNA Interference ; STAT Transcription Factors / metabolism ; Signal Transduction ; Spermatogenesis / genetics ; Spermatogonia / cytology ; Spermatogonia / metabolism ; Spermatozoa / metabolism ; Stem Cells / metabolism ; Transcription Factors / genetics ; Transforming Growth Factor beta / metabolism References: J Biol Chem. 2003 Mar 28;278(13):11696-704. (PMID: 12538650) ; Nat Genet. 2004 Jun;36(6):653-9. (PMID: 15156143) ; Genome Biol. 2005;6(10):R82. (PMID: 16207353) ; Nat Genet. 2004 Jun;36(6):647-52. (PMID: 15156142) ; Science. 2001 Dec 21;294(5551):2542-5. (PMID: 11752574) ; Genes Dev. 2003 Oct 15;17(20):2496-501. (PMID: 14522953) ; Development. 2000 Dec;127(24):5463-73. (PMID: 11076766) ; Development. 1996 Apr;122(4):1331-41. (PMID: 8620860) ; Science. 2009 Oct 2;326(5949):153-6. (PMID: 19797664) ; Science. 2003 Dec 5;302(5651):1727-36. (PMID: 14605208) ; Development. 1998 Jan;125(1):125-34. (PMID: 9389670) ; Development. 2004 Nov;131(21):5297-308. (PMID: 15456720) ; Development. 2007 Apr;134(8):1471-9. (PMID: 17344229) ; Development. 1994 Jun;120(6):1385-98. (PMID: 8050351) ; Mol Cell Biol. 2001 Jun;21(11):3609-15. (PMID: 11340155) ; Cell Stem Cell. 2007 Oct 11;1(4):470-8. (PMID: 18371382) ; Methods. 2003 Aug;30(4):322-9. (PMID: 12828946) ; Genetics. 2004 Jun;167(2):707-23. (PMID: 15238523) ; Development. 1993 Apr;117(4):1223-37. (PMID: 8404527) ; Dev Biol. 2007 Apr 15;304(2):771-85. (PMID: 17336958) ; Development. 1996 Aug;122(8):2437-47. (PMID: 8756289) ; Dev Biol. 1999 Sep 15;213(2):301-13. (PMID: 10479449) ; Science. 1982 Oct 22;218(4570):348-53. (PMID: 6289436) ; Development. 2004 Mar;131(6):1365-75. (PMID: 14973292) ; Nat Neurosci. 2003 Sep;6(9):917-24. (PMID: 12897787) ; Development. 2002 Mar;129(6):1317-25. (PMID: 11880341) ; Nucleic Acids Res. 2009 Jan;37(Database issue):D555-9. (PMID: 18948289) ; Cell Stem Cell. 2008 Jul 3;3(1):44-54. (PMID: 18593558) ; Mol Cell Biol. 1997 Jan;17(1):482-94. (PMID: 8972229) ; Genes Dev. 2001 Apr 15;15(8):1021-30. (PMID: 11316795) ; Neural Dev. 2007 Jul 16;2:14. (PMID: 17634136) ; Science. 2005 Nov 4;310(5749):869-72. (PMID: 16272126) ; Nature. 2006 Jan 26;439(7075):430-6. (PMID: 16437107) ; J Cell Sci. 1996 Dec;109 ( Pt 12):2779-88. (PMID: 9013326) ; Curr Opin Struct Biol. 2001 Feb;11(1):39-46. (PMID: 11179890) ; Curr Biol. 2003 Dec 2;13(23):2065-72. (PMID: 14653996) ; Trends Cell Biol. 2006 Nov;16(11):578-87. (PMID: 16996269) ; Gene. 2003 Jun 5;311:59-69. (PMID: 12853139) ; Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22311-6. (PMID: 20018708) ; Development. 2006 Jan;133(2):229-35. (PMID: 16339185) Grant Information: R01 GM080501 United States GM NIGMS NIH HHS; R01GM080501 United States GM NIGMS NIH HHS Substance Nomenclature: 0 (Drosophila Proteins) ; 0 (Nuclear Proteins) ; 0 (Protein Isoforms) ; 0 (STAT Transcription Factors) ; 0 (Transcription Factors) ; 0 (Transforming Growth Factor beta) ; 0 (lola protein, Drosophila) ; EC 2.7.10.2 (Janus Kinases) Entry Date(s): Date Created: 20121120 Date Completed: 20130221 Latest Revision: 20220309 Update Code: 20240513 PubMed Central ID: PMC4006830

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The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.