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(17)O magnetic resonance imaging (MRI) using a conventional pulse sequence was explored as a method of quantitative imaging towards regional oxygen consumption rate measurement for tumor evaluation in mice. At 7 T, fast imaging with steady state (FISP) was the best among gradient echo, fast spin echo and FISP for the purpose. The distribution of natural abundance H2(17)O in mice was visualized under spatial resolution of 2.5 × 2.5mm(2) by FISP in 10 min. The signal intensity by FISP showed a linear relationship with (17)O quantity both in phantom and mice. Following the injection of 5% (17)O enriched saline, (17)O re-distribution was monitored in temporal resolution down to 5 sec with an image quality sufficient to distinguish each organ. The image of labeled water produced from inhaled (17)O2 gas was also obtained. The present method provides quantitative (17)O images under sufficient temporal and spatial resolution for the evaluation of oxygen consumption rate in each organ. Experiments using various model compounds of R-OH type clarified that the signal contribution of body constituents other than water in the present in vivo(17)O FISP image was negligible.

Titel:	Quantitative 17O imaging towards oxygen consumption study in tumor bearing mice at 7 T.
Autor/in / Beteiligte Person:	Narazaki, M ; Kanazawa, Y ; Koike, S ; Ando, K ; Ikehira, H
Zeitschrift:	Magnetic resonance imaging, Jg. 31 (2013-06-01), Heft 5, S. 643-50
Veröffentlichung:	<2008->: Amsterdam : Elsevier ; <i>Original Publication</i>: New York : Pergamon, c1982-, 2013
Medientyp:	academicJournal
ISSN:	1873-5894 (electronic)
DOI:	10.1016/j.mri.2012.10.009
Schlagwort:	Animals Image Enhancement methods Mammary Neoplasms, Experimental pathology Metabolic Clearance Rate Mice Organ Specificity Oxygen Isotopes pharmacokinetics Radiopharmaceuticals pharmacokinetics Reproducibility of Results Sensitivity and Specificity Tissue Distribution Algorithms Image Interpretation, Computer-Assisted methods Magnetic Resonance Imaging methods Mammary Neoplasms, Experimental metabolism Oxygen metabolism Oxygen Consumption Whole Body Imaging methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Magn Reson Imaging] 2013 Jun; Vol. 31 (5), pp. 643-50. <i>Date of Electronic Publication: </i>2013 Jan 05. MeSH Terms: Algorithms* ; Oxygen Consumption* ; Image Interpretation, Computer-Assisted / methods ; Magnetic Resonance Imaging / methods ; Mammary Neoplasms, Experimental / metabolism ; Oxygen / metabolism ; Whole Body Imaging / *methods ; Animals ; Image Enhancement / methods ; Mammary Neoplasms, Experimental / pathology ; Metabolic Clearance Rate ; Mice ; Organ Specificity ; Oxygen Isotopes / pharmacokinetics ; Radiopharmaceuticals / pharmacokinetics ; Reproducibility of Results ; Sensitivity and Specificity ; Tissue Distribution Substance Nomenclature: 0 (Oxygen Isotopes) ; 0 (Radiopharmaceuticals) ; S88TT14065 (Oxygen) Entry Date(s): Date Created: 20130109 Date Completed: 20140106 Latest Revision: 20151119 Update Code: 20240513

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Quantitative 17O imaging towards oxygen consumption study in tumor bearing mice at 7 T.