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Background: Complex healthcare interventions consist of multiple components which may vary in trials conducted in different populations and contexts. Pooling evidence from trials in a systematic review is challenging because it is unclear which components are needed for effectiveness. The potential is recognised for using recipients' views to explore why some complex interventions are effective and others are not. Methods to maximise this potential are poorly developed.

Methods: We used a novel approach to explore how patients' views may explain the disparity in effectiveness of complex interventions. We used qualitative comparative analysis to explore agreement between qualitative syntheses of data on patients' views and evidence from trialed interventions to increase adherence to treatments. We first populated data matrices to reflect whether the content of each trialed intervention could be matched with suggestions arising from patients' views. We then used qualitative comparative analysis software to identify, by a process of elimination, the smallest number of configurations (patterns) of components that corresponded with patients' suggestions and accounted for whether each intervention was effective or ineffective.

Results: We found suggestions by patients were poorly represented in interventions. Qualitative comparative analysis identified particular combinations of components corresponding with patients' suggestions and with whether an intervention was effective or ineffective. Six patterns were identified for an effective and four for an ineffective intervention. Two types of patterns arose for the effective interventions, one being didactic (providing clear information or instruction) and the other interactive (focusing on personal risk factors).

Conclusions: Our analysis highlights how data on patients' views has the potential to identify key components across trials of complex interventions or inform the content of new interventions to be trialed.

Titel:	Using qualitative evidence on patients' views to help understand variation in effectiveness of complex interventions: a qualitative comparative analysis.
Autor/in / Beteiligte Person:	Candy, B ; King, M ; Jones, L ; Oliver, S
Link:	Full Text Finder (Volltext)
Zeitschrift:	Trials, Jg. 14 (2013-06-18), S. 179
Veröffentlichung:	[London] : BioMed Central, 2006-, 2013
Medientyp:	academicJournal
ISSN:	1745-6215 (electronic)
DOI:	10.1186/1745-6215-14-179
Schlagwort:	Comparative Effectiveness Research Health Knowledge, Attitudes, Practice Humans Patient Compliance Patient Education as Topic Pattern Recognition, Automated Qualitative Research Risk Assessment Risk Factors Software Treatment Outcome Clinical Trials as Topic Evidence-Based Medicine Patients psychology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Language: English [Trials] 2013 Jun 18; Vol. 14, pp. 179. <i>Date of Electronic Publication: </i>2013 Jun 18. MeSH Terms: Clinical Trials as Topic* ; Evidence-Based Medicine* ; Patients / *psychology ; Comparative Effectiveness Research ; Health Knowledge, Attitudes, Practice ; Humans ; Patient Compliance ; Patient Education as Topic ; Pattern Recognition, Automated ; Qualitative Research ; Risk Assessment ; Risk Factors ; Software ; Treatment Outcome References: Lancet. 1976 Jun 12;1(7972):1265-8. (PMID: 73694) ; Clin Nurs Res. 2004 Feb;13(1):69-89. (PMID: 14768768) ; BMJ. 2006 Feb 18;332(7538):413-6. (PMID: 16484270) ; J Am Pharm Assoc (Wash). 2001 May-Jun;41(3):411-20. (PMID: 11372906) ; Ann Intern Med. 2008 Feb 19;148(4):W60-6. (PMID: 18283201) ; AIDS Patient Care STDS. 2004 Jun;18(6):355-63. (PMID: 15294086) ; Cochrane Database Syst Rev. 2008 Apr 16;(2):CD000011. (PMID: 18425859) ; Respir Med. 2000 Sep;94(9):900-8. (PMID: 11001084) ; Soc Sci Med. 2003 Feb;56(4):671-84. (PMID: 12560003) ; AIDS. 2005 May 20;19(8):807-14. (PMID: 15867495) ; Fam Pract. 2005 Apr;22(2):144-51. (PMID: 15655101) ; BMJ. 2008 Jun 28;336(7659):1472-4. (PMID: 18583680) ; Soc Sci Med. 2009 Jan;68(1):154-68. (PMID: 19013702) ; BMJ Open. 2012 Nov 22;2(6):. (PMID: 23180392) ; Age Ageing. 2002 Sep;31(5):365-71. (PMID: 12242199) ; J Am Acad Nurse Pract. 2007 Jul;19(7):358-67. (PMID: 17680901) ; BMJ. 1996 Feb 10;312(7027):345-9. (PMID: 8611831) ; J Health Serv Res Policy. 2010 Jul;15(3):163-70. (PMID: 20555041) ; BMJ. 2004 Apr 24;328(7446):1010-2. (PMID: 15105329) ; BMC Med Res Methodol. 2011 Aug 26;11:124. (PMID: 21871083) ; JAMA. 2006 Dec 6;296(21):2563-71. (PMID: 17101639) ; BMC Med Res Methodol. 2012 Nov 27;12:181. (PMID: 23185978) ; Aten Primaria. 2004 May 15;33(8):443-50. (PMID: 15151791) ; Patient Educ Couns. 2001 Sep;44(3):193-203. (PMID: 11553420) ; Soc Sci Med. 2011 Jun;72(12):1965-74. (PMID: 21640455) ; Br J Psychiatry. 1998 May;172:413-9. (PMID: 9747403) ; Lancet. 2001 Mar 3;357(9257):664-9. (PMID: 11247549) ; AIDS. 2007 Jan 30;21(3):271-81. (PMID: 17255734) ; Thromb Haemost. 2003 Mar;89(3):458-67. (PMID: 12624628) ; BMJ. 1999 Sep 4;319(7210):612-5. (PMID: 10473477) ; Trials. 2011 May 17;12:125. (PMID: 21586143) ; Psychol Med. 2005 Jan;35(1):25-33. (PMID: 15842026) ; Soc Sci Med. 2010 May;70(10):1618-25. (PMID: 20207464) ; Ann Rheum Dis. 2001 Sep;60(9):869-75. (PMID: 11502614) ; Am J Med. 2000 Jan;108(1):20-7. (PMID: 11059437) ; J Hypertens. 2006 Jan;24(1):169-75. (PMID: 16331115) ; Evid Rep Technol Assess (Full Rep). 2012 Jul;(208.5):1-645. (PMID: 24422977) ; Antivir Ther. 2004 Feb;9(1):85-95. (PMID: 15040540) Grant Information: MCCC-FCO-11-U United Kingdom MCCC_ Marie Curie Entry Date(s): Date Created: 20130620 Date Completed: 20131017 Latest Revision: 20240321 Update Code: 20240321 PubMed Central ID: PMC3693880

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Using qualitative evidence on patients' views to help understand variation in effectiveness of complex interventions: a qualitative comparative analysis.