A Multimodal Nanocomposite for Biomedical Imaging.
In: AIP conference proceedings, Jg. 1365 (2011-09-09), S. 379
academicJournal
Zugriff:
A multimodal nanocomposite was designed, synthesized with super-paramagnetic core (CoFe 2 O 4 ), noble metal corona (Au), and semiconductor shell (TiO 2 ). The sizes of core, core-corona, and core-corona-shell particles were determined by TEM. This multimodal nanocrystal showed promise as a contrast agent for two of the most widely used biomedical imaging techniques: magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Finally, these nanocomposites were coated with a peptide SN-50. This led to their ready uptake by the cultured cells and targeted the nanocomposites to the pores of nuclear membrane. Inside cells, this nanocomposite retained its integrity as shown by X-ray fluorescence microscopy (XFM). Inside cells imaged by XFM we found the complex elemental signature of nanoconjugates (Ti-Co-Fe-Au) always co-registered in the 2D elemental map of the cell.
| Titel: |
A Multimodal Nanocomposite for Biomedical Imaging.
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| Autor/in / Beteiligte Person: | Wu, A ; Paunesku, T ; Zhang, Z ; Vogt, S ; Lai, B ; Maser, J ; Yaghmai, V ; Li, D ; Omary, RA ; Woloschak, GE |
| Zeitschrift: | AIP conference proceedings, Jg. 1365 (2011-09-09), S. 379 |
| Veröffentlichung: | New York : American Institute of Physics, 1970-, 2011 |
| Medientyp: | academicJournal |
| ISSN: | 0094-243X (print) |
| DOI: | 10.1063/1.3625382 |
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