Epidemiology and prognosis of synchronous and metachronous colon cancer metastases: a French population-based study.

Ghiringhelli, F ; Hennequin, A ; et al.

In: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, Jg. 46 (2014-09-01), Heft 9, S. 854-8

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Background: Epidemiological data on synchronous and metachronous metastatic colon cancer are scarce. We assessed epidemiological characteristics and survival in synchronous and metachronous metastatic colon cancer in a French population.

Methods: Our study included 932 cases of metastatic colon cancer diagnosed in 1999-2010 and registered in a population-based cancer registry; 758 were synchronous colon metastases and 174 metachronous metastases from resected primary colon cancers diagnosed in 1999-2005. Univariate relative survival was calculated and a multivariate model with proportional hazard applied to net survival by interval was used.

Results: Mean age at diagnosis was 71.1 years for patients with metachronous metastasis and 71.4 years for those with synchronous metastasis (p=0.818). Patients with metachronous metastasis were more likely to have R0 resection (Odds Ratio: 3.05 [1.96-4.76], p<0.001) than patients with synchronous metastasis. Five-year relative survival was 7.2% for synchronous metastasis and 17.6% for metachronous metastasis (p<0.001), but did not differ significantly for patients with R0 resection (47.3% and 61.5% respectively, p=0.120). For patients not receiving chemotherapy risk of death was significantly lower in the metachronous metastasis group (Hazard Ratio=0.44 [0.32-0.60], p<0.001).

Conclusions: On a population basis, synchronous metastasis is an independent poor prognostic factor in colon cancer. Chemotherapy and resection of all metastatic sites significantly improved the outcome in patients with synchronous metastasis.

Titel:	Epidemiology and prognosis of synchronous and metachronous colon cancer metastases: a French population-based study.
Autor/in / Beteiligte Person:	Ghiringhelli, F ; Hennequin, A ; Drouillard, A ; Lepage, C ; Faivre, J ; Bouvier, AM
Zeitschrift:	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, Jg. 46 (2014-09-01), Heft 9, S. 854-8
Veröffentlichung:	2003- : Amsterdam : Elsevier ; <i>Original Publication</i>: Roma, Italy : Editrice gastroenterologica italiana, c2000-, 2014
Medientyp:	academicJournal
ISSN:	1878-3562 (electronic)
DOI:	10.1016/j.dld.2014.05.011
Schlagwort:	Aged Female Follow-Up Studies France epidemiology Humans Male Morbidity trends Prognosis Retrospective Studies Risk Factors Survival Rate trends Colonic Neoplasms epidemiology Colonic Neoplasms secondary Neoplasms, Multiple Primary Neoplasms, Second Primary Population Surveillance
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Dig Liver Dis] 2014 Sep; Vol. 46 (9), pp. 854-8. <i>Date of Electronic Publication: </i>2014 Jun 05. MeSH Terms: Neoplasms, Multiple Primary* ; Neoplasms, Second Primary* ; Population Surveillance* ; Colonic Neoplasms / epidemiology ; Colonic Neoplasms / secondary ; Aged ; Female ; Follow-Up Studies ; France / epidemiology ; Humans ; Male ; Morbidity / trends ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate / trends Contributed Indexing: Keywords: Colon cancer; Epidemiology; Metachronous metastasis; Registry; Synchronous metastasis Entry Date(s): Date Created: 20140609 Date Completed: 20150519 Latest Revision: 20220408 Update Code: 20231215

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