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Background: Non-shivering thermogenesis (NST) involves a substantial amount of energy expenditure in humans and, thus, contributes to reducing the risk for obesity. Molecular evolutionary studies have reported that SNPs in/near the uncoupling protein 3 gene (UCP3) and the regulatory associated protein of mTOR complex 1 gene (RPTOR) might influence NST and confer adaptive advantages for modern human dispersal into cold environments. In the present study, the impact of these SNPs on obesity-related traits was investigated.

Methods: Study subjects consisted of 2,834 Japanese adults (percentage of female: 46%, mean age: 51.5). Associations of the UCP3-55C/T and the RPTOR-26934C/T - the 2 potential genetic variations involved in cold adaptation and thermogenic mechanisms in mammals, with quantitative obesity-related traits including body mass index (BMI), waist circumference, visceral fat area (VFA), VFA adjusted for BMI, and selected blood parameters - were tested using multiple linear regression models. Sliding windowsampling analysis was applied to depict seasonal effects of the SNPs on the obesity-related phenotypes.

Results: UCP3-55C/T and the RPTOR-26934C/T did not show any association with obesity traits and blood chemical parameters in multiple linear regression models consisting of the whole subjects. Moreover, sliding window sampling-based association analyses involving seasonality also failed to find associations between these two SNPs and obesity-related traits.

Conclusions: UCP3-55C/T and the RPTOR-26934C/T may only have subtle effects on the development of obesity-related traits in the present humans. These two SNPs might be irrelevant to inter-individual variations in energy metabolism and efficiency of NST.

Titel:	Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults.
Autor/in / Beteiligte Person:	Nakayama, K ; Miyashita, H ; Iwamoto, S
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of physiological anthropology, Jg. 33 (2014-12-22), S. 38
Veröffentlichung:	2012- : London : BioMed Central ; <i>Original Publication</i>: Tokyo : Japan Society of Physiological Anthropology, [2006]-, 2014
Medientyp:	academicJournal
ISSN:	1880-6805 (electronic)
DOI:	10.1186/1880-6805-33-38
Schlagwort:	Adult Body Mass Index Cholesterol blood Female Humans Japan Male Middle Aged Polymorphism, Single Nucleotide Regulatory-Associated Protein of mTOR Uncoupling Protein 3 Waist Circumference Adaptor Proteins, Signal Transducing genetics Asian People genetics Intra-Abdominal Fat physiology Ion Channels genetics Mitochondrial Proteins genetics Obesity genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Physiol Anthropol] 2014 Dec 22; Vol. 33, pp. 38. <i>Date of Electronic Publication: </i>2014 Dec 22. MeSH Terms: Adaptor Proteins, Signal Transducing / genetics ; Asian People / genetics ; Intra-Abdominal Fat / physiology ; Ion Channels / genetics ; Mitochondrial Proteins / genetics ; Obesity / genetics ; Adult ; Body Mass Index ; Cholesterol / blood ; Female ; Humans ; Japan ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Regulatory-Associated Protein of mTOR ; Uncoupling Protein 3 ; Waist Circumference References: Cell. 2002 Jul 26;110(2):177-89. (PMID: 12150926) ; PLoS One. 2014;9(5):e96411. (PMID: 24804925) ; Physiol Behav. 2004 Sep 15;82(2-3):545-53. (PMID: 15276821) ; J Appl Physiol (1985). 1997 Jul;83(1):229-39. (PMID: 9216968) ; Comp Biochem Physiol A Mol Integr Physiol. 2004 Oct;139(2):229-38. (PMID: 15528172) ; Diabetes Care. 2005 Feb;28(2):451-3. (PMID: 15677816) ; Cell Metab. 2005 Aug;2(2):85-93. (PMID: 16098826) ; PLoS Genet. 2008 Feb;4(2):e32. (PMID: 18282109) ; Cell Metab. 2008 Nov;8(5):399-410. (PMID: 19046571) ; N Engl J Med. 2009 Apr 9;360(15):1500-8. (PMID: 19357405) ; N Engl J Med. 2009 Apr 9;360(15):1509-17. (PMID: 19357406) ; N Engl J Med. 2009 Apr 9;360(15):1518-25. (PMID: 19357407) ; Diabetes. 2009 Jul;58(7):1526-31. (PMID: 19401428) ; PLoS Genet. 2010 Oct;6(10):e1001178. (PMID: 21060808) ; Mol Biol Evol. 2011 Jan;28(1):601-14. (PMID: 20802238) ; PLoS Genet. 2011 Apr;7(4):e1001375. (PMID: 21533023) ; Int J Obes (Lond). 2011 Aug;35(8):1050-5. (PMID: 21189472) ; Obesity (Silver Spring). 2011 Sep;19(9):1755-60. (PMID: 21566561) ; Exp Gerontol. 2011 Nov;46(11):897-904. (PMID: 21827845) ; Trends Endocrinol Metab. 2012 Sep;23(9):451-8. (PMID: 22591987) ; J Physiol Anthropol. 2012;31:22. (PMID: 22929588) ; Hum Genet. 2013 Feb;132(2):201-17. (PMID: 23108367) ; PLoS One. 2013;8(1):e54259. (PMID: 23365654) ; PLoS One. 2013;8(4):e58939. (PMID: 23560041) ; Nat Genet. 2013 May;45(5):501-12. (PMID: 23563607) ; Int J Obes (Lond). 2013 Jul;37(7):993-8. (PMID: 23032405) ; PLoS One. 2013;8(9):e74720. (PMID: 24086366) ; Endocrinology. 2014 May;155(5):1573-88. (PMID: 24605831) ; Br J Sports Med. 2003;37(5):436-40. (PMID: 14514537) Substance Nomenclature: 0 (Adaptor Proteins, Signal Transducing) ; 0 (Ion Channels) ; 0 (Mitochondrial Proteins) ; 0 (RPTOR protein, human) ; 0 (Regulatory-Associated Protein of mTOR) ; 0 (UCP3 protein, human) ; 0 (Uncoupling Protein 3) ; 97C5T2UQ7J (Cholesterol) Entry Date(s): Date Created: 20141224 Date Completed: 20150515 Latest Revision: 20221207 Update Code: 20240513 PubMed Central ID: PMC4347541

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Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults.