Einzeltreffer — DigiBib

Background/objectives: Fatty acids are hypothesized to influence cardiovascular disease risk because of their effect on inflammation. The aim of this study is to assess the relationship between whole-blood fatty acids (WBFAs) and high-sensitivity C-reactive protein (hs-CRP) in European children.

Subjects/methods: A total of 1401 subjects (697 boys and 704 girls) aged between 2 and 9 years from the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects in Children and infantS) study were measured in this cross-sectional analysis. The sample was divided into three categories of hs-CRP. Associations between WBFA and hs-CRP were assessed by logistic regression models adjusting for body mass index (BMI), country, age, breastfeeding, mother's education and hours of physical activity.

Results: Linoleic acid (LA) (P=0.013, 95% confidence interval (CI): 0.822-0.977) and sum of n-6 WBFA (P=0.029, 95% CI: 0.866-0.992) concentrations were associated with lower concentrations of hs-CRP in boys. In girls, a high ratio of eicosapentaenoic acid (EPA)/arachidonic acid (AA) was associated (P=0.018, 95% CI: 0.892-0.989) with lower hs-CRP concentrations. In contrast, sum of blood n-6 highly unsaturated fatty acids (P=0.012, 95% CI: 1.031-1.284), AA (P=0.007, 95% CI: 1.053-1.395) and AA/LA ratio (P=0.005, 95% CI: 1.102-1.703) were associated (P<0.05) with higher concentrations of hs-CRP in girls.

Conclusions: The n-6 WBFAs (sum of n-6 FA and LA) were associated with lower hs-CRP in boys and with higher hs-CRP in girls (AA, sum of n-6 highly unsaturated and AA/LA ratio). More studies are needed to identify the optimal levels of WBFAs to avoid low-grade inflammation in children considering the differences by sex and BMI.

Titel:	Whole-blood fatty acids and inflammation in European children: the IDEFICS Study.
Autor/in / Beteiligte Person:	González-Gil, EM ; Santabárbara, J ; Siani, A ; Ahrens, W ; Sioen, I ; Eiben, G ; Günther, K ; Iacoviello, L ; Molnar, D ; Risé, P ; Russo, P ; Tornaritis, M ; Veidebaum, T ; Galli, C ; Moreno, LA
Link:	Full Text Finder (Volltext)
Zeitschrift:	European journal of clinical nutrition, Jg. 70 (2016-07-01), Heft 7, S. 819-23
Veröffentlichung:	<2003->: London : Nature Publishing Group ; <i>Original Publication</i>: London : J. Libbey, c1988-, 2016
Medientyp:	academicJournal
ISSN:	1476-5640 (electronic)
DOI:	10.1038/ejcn.2015.219
Schlagwort:	Child Child, Preschool Cross-Sectional Studies Diet Europe Fatty Acids, Unsaturated blood Female Humans Inflammation blood Logistic Models Male Nutritional Status Sex Factors Arachidonic Acid blood C-Reactive Protein metabolism Dietary Fats blood Eicosapentaenoic Acid blood Fatty Acids, Omega-6 blood Inflammation etiology Linoleic Acid blood
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Eur J Clin Nutr] 2016 Jul; Vol. 70 (7), pp. 819-23. <i>Date of Electronic Publication: </i>2016 Jan 13. MeSH Terms: Arachidonic Acid / blood ; C-Reactive Protein / metabolism ; Dietary Fats / blood ; Eicosapentaenoic Acid / blood ; Fatty Acids, Omega-6 / blood ; Inflammation / etiology ; Linoleic Acid / *blood ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diet ; Europe ; Fatty Acids, Unsaturated / blood ; Female ; Humans ; Inflammation / blood ; Logistic Models ; Male ; Nutritional Status ; Sex Factors References: Int J Obes (Lond). 2011 Apr;35 Suppl 1:S45-51. (PMID: 21483422) ; Am J Cardiol. 2013 Jan 1;111(1):6-11. (PMID: 23040588) ; Int J Obes (Lond). 2011 Apr;35 Suppl 1:S3-15. (PMID: 21483420) ; J Atheroscler Thromb. 2011;18(2):99-107. (PMID: 21099130) ; Circulation. 2003 Jul 15;108(2):155-60. (PMID: 12821543) ; Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1323-8. (PMID: 12171795) ; Int J Obes Relat Metab Disord. 2004 Nov;28 Suppl 3:S59-63. (PMID: 15543221) ; Am J Clin Nutr. 2000 Jan;71(1 Suppl):213S-23S. (PMID: 10617974) ; Biochem Biophys Res Commun. 2007 Jun 22;358(1):150-5. (PMID: 17467667) ; Obes Rev. 2012 May;13(5):441-55. (PMID: 22133012) ; J Clin Endocrinol Metab. 2006 Feb;91(2):439-46. (PMID: 16234304) ; Eur J Epidemiol. 2010 Sep;25(9):607-17. (PMID: 20567998) ; Br J Nutr. 2011 Dec;106 Suppl 3:S5-78. (PMID: 22133051) ; J Am Heart Assoc. 2013 Jun 06;2(3):e000101. (PMID: 23744403) ; Anal Biochem. 2004 Mar 15;326(2):267-72. (PMID: 15003567) ; Am J Clin Nutr. 2006 Jun;83(6):1369-79. (PMID: 16762949) ; Circulation. 2003 Sep 2;108(9):1053-8. (PMID: 12925465) ; Arterioscler Thromb Vasc Biol. 2006 May;26(5):995-1001. (PMID: 16484595) ; Lipids. 1996 Mar;31 Suppl:S57-63. (PMID: 8729095) ; Proc Nutr Soc. 2008 Feb;67(1):19-27. (PMID: 18234128) ; Am J Clin Nutr. 2006 Feb;83(2):461S-465S. (PMID: 16470013) ; Obes Surg. 2012 Aug;22(8):1220-4. (PMID: 22467001) ; Am J Clin Nutr. 2001 Apr;73(4):673-86. (PMID: 11273841) ; Am J Cardiol. 2009 May 1;103(9):1238-43. (PMID: 19406265) ; Circulation. 2013 Nov 5;128(19):2154-61. (PMID: 24190935) ; J Cardiovasc Med (Hagerstown). 2007 Sep;8 Suppl 1:S11-4. (PMID: 17876190) ; Am J Clin Nutr. 2011 Dec;94(6 Suppl):1914S-1919S. (PMID: 22089435) ; Atherosclerosis. 2013 Dec;231(2):261-7. (PMID: 24267237) ; N Engl J Med. 1999 Jan 14;340(2):115-26. (PMID: 9887164) ; Am J Clin Nutr. 2006 Jun;83(6 Suppl):1505S-1519S. (PMID: 16841861) ; Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):215-20. (PMID: 23910046) ; Am J Clin Nutr. 2003 Feb;77(2):319-25. (PMID: 12540389) ; J Nutr Biochem. 2010 Sep;21(9):781-92. (PMID: 20382009) ; Br J Nutr. 2008 Jan;99(1):168-74. (PMID: 17678566) ; Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S14-9. (PMID: 12142955) ; Atherosclerosis. 2000 Mar;149(1):139-50. (PMID: 10704625) ; J Lipid Res. 2010 Aug;51(8):2325-33. (PMID: 20427696) ; Am J Prev Med. 2010 Oct;39(4):314-20. (PMID: 20837281) ; J Exp Med. 2000 Oct 16;192(8):1197-204. (PMID: 11034610) ; Hepatology. 2007 Sep;46(3):823-30. (PMID: 17680645) Substance Nomenclature: 0 (Dietary Fats) ; 0 (Fatty Acids, Omega-6) ; 0 (Fatty Acids, Unsaturated) ; 27YG812J1I (Arachidonic Acid) ; 9007-41-4 (C-Reactive Protein) ; 9KJL21T0QJ (Linoleic Acid) ; AAN7QOV9EA (Eicosapentaenoic Acid) Entry Date(s): Date Created: 20160114 Date Completed: 20180126 Latest Revision: 20181113 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Whole-blood fatty acids and inflammation in European children: the IDEFICS Study.