Einzeltreffer — DigiBib

Objective: To assess the effects of supervised and home-based aerobic exercise training, and antidepressant pharmacotherapy (sertraline) on coronary heart disease (CHD) risk factors in a sample of participants with major depressive disorder (MDD).

Methods: The Standard Medical Intervention versus Long-term Exercise (SMILE)-II study randomized 202 adults (153 women, 49 men) diagnosed as having MDD to one of four interventions, each of 4-month duration: supervised exercise, home-based exercise, antidepressant medication (sertraline, 50-200 mg daily), or placebo pill. Patients underwent a structured clinical interview for depression and completed the Hamilton Depression Rating Scale. CHD risk factors included brachial artery flow-mediated dilation, carotid intima-media thickness, serum lipids, and 10-year atherosclerotic cardiovascular disease (ASCVD) risk.

Results: Compared with placebo, active treatment of depression (supervised exercise, home-based exercise, sertraline therapy) was associated with an improvement in CHD risk factors (improved flow-mediated dilation [p = .032], reduced progression of intima-media thickness [p = .037], and a reduction in 10-year ASCVD [p = .049]). The active treatments did not differ from each other in their effects on the CHD risk outcomes.

Conclusions: Both exercise and antidepressant medication improved CHD risk factors and lowered ASCVD risk in patients with MDD. Because MDD is associated with increased risk for CHD events, treatment of depression with exercise or sertraline may reduce the risk of developing CHD in patients with MDD.

Trial Registration: Clinical Trials Government Identifier: NCT-00331305.

Titel:	Effects of Exercise and Sertraline on Measures of Coronary Heart Disease Risk in Patients With Major Depression: Results From the SMILE-II Randomized Clinical Trial.
Autor/in / Beteiligte Person:	Sherwood, A ; Blumenthal, JA ; Smith, PJ ; Watkins, LL ; Hoffman, BM ; Hinderliter, AL
Zeitschrift:	Psychosomatic medicine, Jg. 78 (2016-06-01), Heft 5, S. 602-9
Veröffentlichung:	Hagerstown, MD : Lippincott Williams & Wilkins ; <i>Original Publication</i>: Baltimore [etc.], 2016
Medientyp:	academicJournal
ISSN:	1534-7796 (electronic)
DOI:	10.1097/PSY.0000000000000301
Schlagwort:	Adult Combined Modality Therapy Depressive Disorder, Major drug therapy Female Humans Male Middle Aged Risk Selective Serotonin Reuptake Inhibitors administration & dosage Sertraline administration & dosage Coronary Disease diagnostic imaging Coronary Disease prevention & control Depressive Disorder, Major therapy Exercise Therapy methods Outcome Assessment, Health Care Selective Serotonin Reuptake Inhibitors pharmacology Sertraline pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Randomized Controlled Trial Language: English [Psychosom Med] 2016 Jun; Vol. 78 (5), pp. 602-9. MeSH Terms: Outcome Assessment, Health Care* ; Coronary Disease / diagnostic imaging ; Coronary Disease / prevention & control ; Depressive Disorder, Major / therapy ; Exercise Therapy / methods ; Selective Serotonin Reuptake Inhibitors / pharmacology ; Sertraline / pharmacology ; Adult ; Combined Modality Therapy ; Depressive Disorder, Major / drug therapy ; Female ; Humans ; Male ; Middle Aged ; Risk ; Selective Serotonin Reuptake Inhibitors / administration & dosage ; Sertraline / administration & dosage References: Cardiovasc Ultrasound. 2014 Aug 23;12:34. (PMID: 25148901) ; Psychosom Med. 2007 Sep-Oct;69(7):587-96. (PMID: 17846259) ; JAMA. 2003 Jun 18;289(23):3106-16. (PMID: 12813116) ; Scand J Med Sci Sports. 2014 Apr;24(2):259-72. (PMID: 23362828) ; J Am Coll Cardiol. 2012 Sep 18;60(12):1053-63. (PMID: 22858387) ; Circulation. 2014 Mar 25;129(12):1350-69. (PMID: 24566200) ; Br J Psychiatry. 2013 Aug;203(2):90-102. (PMID: 23908341) ; J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2935-2959. (PMID: 24239921) ; J Am Coll Cardiol. 2003 Sep 17;42(6):1037-43. (PMID: 13678927) ; N Engl J Med. 2011 Jul 21;365(3):213-21. (PMID: 21774709) ; Am J Med. 2004 May 15;116(10):682-92. (PMID: 15121495) ; Psychosom Med. 2004 Nov-Dec;66(6):802-13. (PMID: 15564343) ; Arch Gen Psychiatry. 2001 Mar;58(3):221-7. (PMID: 11231827) ; Circulation. 1996 Jun 1;93(11):1976-80. (PMID: 8640971) ; JAMA. 1993 Oct 20;270(15):1819-25. (PMID: 8411525) ; Eur J Vasc Endovasc Surg. 2008 Mar;35(3):264-72. (PMID: 17988901) ; JAMA. 1988 Aug 19;260(7):945-50. (PMID: 3398199) ; J Appl Physiol (1985). 2008 Oct;105(4):1323-32. (PMID: 18583377) ; Am J Cardiol. 1988 Jan 1;61(1):26-30. (PMID: 3337013) ; Clin Sci (Lond). 2012 Apr;122(7):311-22. (PMID: 22150253) ; J Am Coll Cardiol. 2010 Aug 24;56(9):692-9. (PMID: 20723799) ; Psychosom Med. 2004 Nov-Dec;66(6):814-22. (PMID: 15564344) ; Circulation. 2002 Aug 6;106(6):640-2. (PMID: 12163419) ; Circulation. 2007 Jan 30;115(4):459-67. (PMID: 17242284) ; Biometrics. 1984 Dec;40(4):1079-87. (PMID: 6534410) ; Med Sci Sports Exerc. 2004 May;36(5):746-55. (PMID: 15126705) ; JAMA. 2002 Aug 14;288(6):701-9. (PMID: 12169073) ; Am J Cardiol. 2000 Jul 15;86(2):207-10. (PMID: 10913483) ; Arch Intern Med. 1998 Jul 13;158(13):1422-6. (PMID: 9665350) ; JAMA. 2012 Aug 1;308(5):465-74. (PMID: 22851113) ; Circulation. 2000 Oct 10;102(15):1773-9. (PMID: 11023931) ; Epidemiology. 1993 Jul;4(4):285-94. (PMID: 8347738) ; BMJ. 2001 Mar 31;322(7289):763-7. (PMID: 11282860) ; Cochrane Database Syst Rev. 2009 Jul 08;(3):CD004366. (PMID: 19588354) ; Circulation. 2001 Nov 27;104(22):2673-8. (PMID: 11723017) ; JAMA. 2009 Apr 8;301(14):1439-50. (PMID: 19351941) ; J Am Coll Cardiol. 2003 May 21;41(10):1769-75. (PMID: 12767663) ; Circulation. 1989 Aug;80(2):234-44. (PMID: 2665973) Grant Information: R01 HL093374 United States HL NHLBI NIH HHS; R01 HL101383 United States HL NHLBI NIH HHS; R01 MH049679 United States MH NIMH NIH HHS Molecular Sequence: ClinicalTrials.gov NCT00331305 Substance Nomenclature: 0 (Serotonin Uptake Inhibitors) ; QUC7NX6WMB (Sertraline) Entry Date(s): Date Created: 20160212 Date Completed: 20170731 Latest Revision: 20240528 Update Code: 20240528 PubMed Central ID: PMC4905719

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Effects of Exercise and Sertraline on Measures of Coronary Heart Disease Risk in Patients With Major Depression: Results From the SMILE-II Randomized Clinical Trial.