Exploring the relationship between social attachment and dopamine D <subscript>2/3</subscript> receptor availability in the brains of healthy humans using [ <superscript>11</superscript> C]-(+)-PHNO.
In: Social neuroscience, Jg. 12 (2017-04-01), Heft 2, S. 163-173
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Zugriff:
Differences in striatal dopamine (DA) function may be related to differences in the degree of social attachment to others. Using positron emission tomography (PET), socially detached persons demonstrate reduced DA D 2/3 receptor (D 2/3 R) availability in the striatum. However, previous PET studies have only used antagonist radiotracers for D 2/3 R and have not specifically examined regions of interest (ROIs) such as the ventral striatum (VS). In 32 healthy persons, we investigated the relationship between self-reported attachment and DA D 2/3 R availability in striatal and extrastriatal ROIs as measured using the agonist radiotracer [ 11 C]-(+)-PHNO. Surprisingly, more social attachment-as measured by the attachment subscale of the temperament and character inventory-was related to less [ 11 C]-(+)-PHNO binding in the VS (r(30) = -.43, p = .01). This relationship held in a subsample who also completed the detachment subscale of the Karolinska Scales of Personality (r(10) = .62, p = .03). However, no relationships were observed with BP ND in the dorsal striatum or D 3 R-specific ROIs. One potential explanation for these findings is that persons who are more socially detached have less endogenous DA occupying D 2/3 R in the VS. This interpretation warrants investigation by future research. These findings may help us better understand the neurochemical basis of attachment.
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Exploring the relationship between social attachment and dopamine D <subscript>2/3</subscript> receptor availability in the brains of healthy humans using [ <superscript>11</superscript> C]-(+)-PHNO.
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Autor/in / Beteiligte Person: | Caravaggio, F ; Chung, JK ; Gerretsen, P ; Fervaha, G ; Nakajima, S ; Plitman, E ; Iwata, Y ; Wilson, A ; Graff-Guerrero, A |
Zeitschrift: | Social neuroscience, Jg. 12 (2017-04-01), Heft 2, S. 163-173 |
Veröffentlichung: | 2013- : London : Routledge ; <i>Original Publication</i>: Hove : Psychology Press, c2006-, 2017 |
Medientyp: | academicJournal |
ISSN: | 1747-0927 (electronic) |
DOI: | 10.1080/17470919.2016.1152997 |
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