Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study.

Au Yeung, SL ; Cheng, KK ; et al.

In: Annals of epidemiology, Jg. 26 (2016-03-01), Heft 3, S. 171-5

academicJournal

Purpose: The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies.

Methods: We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong (n = 236).

Results: Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (-0.01, 95% confidence interval = -1.34 to 1.31).

Conclusions: Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.

Titel:	Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study.
Autor/in / Beteiligte Person:	Au Yeung, SL ; Cheng, KK ; Zhao, J ; Zhang, W ; Jiang, C ; Lam, TH ; Leung, GM ; Schooling, CM
Zeitschrift:	Annals of epidemiology, Jg. 26 (2016-03-01), Heft 3, S. 171-5
Veröffentlichung:	New York, NY : Elsevier, c1990-, 2016
Medientyp:	academicJournal
ISSN:	1873-2585 (electronic)
DOI:	10.1016/j.annepidem.2016.01.005
Schlagwort:	Aged Aged, 80 and over Cardiovascular Diseases epidemiology Cardiovascular Diseases etiology Cardiovascular Diseases metabolism China epidemiology Cohort Studies Estradiol metabolism Female Genetic Markers Hong Kong epidemiology Humans Mendelian Randomization Analysis Middle Aged Risk Factors Young Adult Cardiovascular Diseases genetics Estradiol genetics Polymorphism, Single Nucleotide
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Ann Epidemiol] 2016 Mar; Vol. 26 (3), pp. 171-5. <i>Date of Electronic Publication: </i>2016 Feb 04. MeSH Terms: Polymorphism, Single Nucleotide* ; Cardiovascular Diseases / genetics ; Estradiol / genetics ; Aged ; Aged, 80 and over ; Cardiovascular Diseases / epidemiology ; Cardiovascular Diseases / etiology ; Cardiovascular Diseases / metabolism ; China / epidemiology ; Cohort Studies ; Estradiol / metabolism ; Female ; Genetic Markers ; Hong Kong / epidemiology ; Humans ; Mendelian Randomization Analysis ; Middle Aged ; Risk Factors ; Young Adult Contributed Indexing: Keywords: Cardiovascular risk factors; Chinese; Estrogen; Mendelian randomization analysis; Women Substance Nomenclature: 0 (Genetic Markers) ; 4TI98Z838E (Estradiol) Entry Date(s): Date Created: 20160225 Date Completed: 20161222 Latest Revision: 20161230 Update Code: 20231215

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