Insulin like activity in (-) epicatechin.
In: Acta diabetologica latina, Jg. 26 (1989-10-01), Heft 4, S. 291-300
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Zugriff:
Water extract of the bark of plant of Pterocarpus marsupium Roxb is used as an antidiabetic drug in indigenous medicine in India. (-) Epicatechin, its active principle, has been found to be insulinogenic. The present in vitro study reports some insulin like activities of (-) epicatechin. Like insulin, (-) epicatechin stimulates oxygen uptake in fat cells and tissue slices of various organs, increases glycogen content of rat diaphragm in dose-dependent manner with corresponding increase in U14-C glucose uptake, and inhibits theophylline induced lipolysis in isolated fat pads in dose-dependent manner. Experiments on competitive binding of 125I-insulin and (-) epicatechin to liver cell plasma membrane indicate that insulin does not share binding site with (-) epicatechin. (-) Epicatechin at a concentration of up to 1 mM does not effect the release of glucagon from the islets in vitro. Thus, (-) epicatechin has insulinogenic as well as insulin like properties.
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Insulin like activity in (-) epicatechin.
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Autor/in / Beteiligte Person: | Ahmad, F ; Khalid, P ; Khan, MM ; Rastogi, AK ; Kidwai, JR |
Zeitschrift: | Acta diabetologica latina, Jg. 26 (1989-10-01), Heft 4, S. 291-300 |
Veröffentlichung: | Milano, Casa editrice Il Ponte., 1989 |
Medientyp: | academicJournal |
ISSN: | 0001-5563 (print) |
DOI: | 10.1007/BF02624640 |
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