No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.
In: BMC psychiatry, Jg. 16 (2016-07-04), S. 206
Online
academicJournal
Zugriff:
Background: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.
Methods: We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.
Results: No significant association was found between the SCZ patients and controls for any allele or genotype frequency of the SNP rs10503253 (all P > 0.05).
Conclusions: Our findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population.
| Titel: |
No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.
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| Autor/in / Beteiligte Person: | Liu, Y ; Cheng, Z ; Wang, J ; Jin, C ; Yuan, J ; Wang, G ; Zhang, F ; Zhao, X |
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| Zeitschrift: | BMC psychiatry, Jg. 16 (2016-07-04), S. 206 |
| Veröffentlichung: | London : BioMed Central, [2001-, 2016 |
| Medientyp: | academicJournal |
| ISSN: | 1471-244X (electronic) |
| DOI: | 10.1186/s12888-016-0923-5 |
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