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The mechanisms involved in the weight loss seen after vertical sleeve gastrectomy (VSG) are not clear. The rat stomach has two morphologically and functionally distinct proximal and distal parts. The rat model for VSG involves complete removal of the proximal part and 80% removal of the distal part along the greater curvature. The purpose of this study was to understand the potential independent contributions of removal of these distinct gastric sections to VSG outcomes. We prepared four surgical groups of male Long-Evans rats: VSG, sham surgery (control), selective proximal section removal (PR), and selective distal section removal (DR). Gastric emptying rate (GER) was highest after VSG compared with all other groups. However, PR, in turn, had significantly greater GER compared with both DR and sham groups. The surgery-induced weight loss followed the same pattern with VSG causing the greatest weight loss and PR having greater weight loss compared with DR and sham groups. The results were robust for rats fed regular chow or a high-fat diet. Body mass analysis revealed that the weight loss was due to the loss of fat mass, and there was no change in lean mass after the surgeries. In conclusion, removal of the proximal stomach contributes to most, but not all, of the physiological impact of VSG.

Titel:	The role of proximal versus distal stomach resection in the weight loss seen after vertical sleeve gastrectomy.
Autor/in / Beteiligte Person:	Kulkarni, BV ; LaSance, K ; Sorrell, JE ; Lemen, L ; Woods, SC ; Seeley, RJ ; Sandoval, D
Link:	Full Text Finder (Volltext)
Zeitschrift:	American journal of physiology. Regulatory, integrative and comparative physiology, Jg. 311 (2016-11-01), Heft 5, S. R979-R987
Veröffentlichung:	Bethesda, Md. : American Physiological Society, 2016
Medientyp:	academicJournal
ISSN:	1522-1490 (electronic)
DOI:	10.1152/ajpregu.00125.2016
Schlagwort:	Animals Gastric Emptying Male Obesity diagnosis Rats Rats, Long-Evans Treatment Outcome Gastrectomy Obesity physiopathology Obesity surgery Stomach physiopathology Stomach surgery Weight Loss physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Am J Physiol Regul Integr Comp Physiol] 2016 Nov 01; Vol. 311 (5), pp. R979-R987. <i>Date of Electronic Publication: </i>2016 Aug 31. MeSH Terms: Gastrectomy* ; Obesity / physiopathology ; Obesity / surgery ; Stomach / physiopathology ; Stomach / surgery ; Weight Loss / *physiology ; Animals ; Gastric Emptying ; Male ; Obesity / diagnosis ; Rats ; Rats, Long-Evans ; Treatment Outcome References: J Nucl Med. 1992 Jul;33(7):1283-90. (PMID: 1613566) ; Sci Transl Med. 2013 Aug 21;5(199):199ra112. (PMID: 23966301) ; Life Sci. 1991;48(2):123-34. (PMID: 1825231) ; Am J Gastroenterol. 1988 Dec;83(12):1364-7. (PMID: 3195541) ; Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1076-84. (PMID: 22932782) ; Int J Obes (Lond). 2013 Feb;37(2):288-95. (PMID: 22334194) ; Gastroenterology. 2013 Jan;144(1):50-52.e5. (PMID: 22995675) ; Obes Surg. 2011 Jul;21(7):858-63. (PMID: 20730606) ; N Engl J Med. 2004 Dec 23;351(26):2683-93. (PMID: 15616203) ; Dan Med Bull. 1991 Aug;38(4):347-65. (PMID: 1914534) ; Int J Obes Relat Metab Disord. 2000 Jul;24(7):899-905. (PMID: 10918538) ; Am J Physiol. 1980 Aug;239(2):G71-6. (PMID: 6996495) ; J Physiol. 1951 Apr;113(2-3):157-68. (PMID: 14832765) ; Gastroenterology. 2011 Sep;141(3):939-949.e1-4. (PMID: 21699773) ; Gastroenterology. 2010 Jun;138(7):2426-36, 2436.e1-3. (PMID: 20226189) ; Obes Surg. 2009 Nov;19(11):1515-21. (PMID: 19714384) ; Int J Obes. 1983;7(5):415-21. (PMID: 6642853) ; Br J Radiol. 1988 Jan;61(721):12-8. (PMID: 3349238) ; Gastroenterology. 2004 Jul;127(1):139-44. (PMID: 15236180) ; Obesity (Silver Spring). 2014 Feb;22(2):390-400. (PMID: 23804416) ; Obes Surg. 2007 Jan;17(1):57-62. (PMID: 17355769) ; Nature. 2014 May 8;509(7499):183-8. (PMID: 24670636) ; Gastroenterology. 2011 Sep;141(3):950-8. (PMID: 21699789) ; Obes Surg. 2008 Oct;18(10):1251-6. (PMID: 18663545) ; Surg Obes Relat Dis. 2011 Jul-Aug;7(4):500-5. (PMID: 21459682) ; JAMA. 2005 Oct 19;294(15):1909-17. (PMID: 16234497) ; J Clin Endocrinol Metab. 1983 Apr;56(4):744-50. (PMID: 6833461) ; Int J Obes Relat Metab Disord. 1993 May;17(5):295-300. (PMID: 8389339) ; J Diabetes Sci Technol. 2007 Mar;1(2):251-9. (PMID: 19888414) ; Obes Surg. 2011 Jan;21(1):95-101. (PMID: 21088924) ; Diabetes Care. 2003 Mar;26(3):881-5. (PMID: 12610053) ; Gastroenterology. 1983 Apr;84(4):747-51. (PMID: 6825986) ; JAMA. 2016 Jun 7;315(21):2284-91. (PMID: 27272580) ; Obes Surg. 2011 Nov;21(11):1774-80. (PMID: 21874366) ; Diabetes. 2013 Jul;62(7):2380-5. (PMID: 23434938) ; Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):101-19. (PMID: 20136593) ; Obesity (Silver Spring). 2014 Sep;22(9):2003-9. (PMID: 24829088) ; Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E424-32. (PMID: 24368666) ; Surg Obes Relat Dis. 2011 Jul-Aug;7(4):506-9. (PMID: 21411376) ; Ann Surg. 2009 Aug;250(2):234-41. (PMID: 19638921) ; Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G424-31. (PMID: 11841992) ; N Engl J Med. 2012 Apr 26;366(17):1567-76. (PMID: 22449319) Grant Information: P30 DK020572 United States DK NIDDK NIH HHS; R01 DK082480 United States DK NIDDK NIH HHS Contributed Indexing: Keywords: gastric emptying rate; sleeve gastrectomy; weight loss Entry Date(s): Date Created: 20160902 Date Completed: 20170626 Latest Revision: 20200930 Update Code: 20240513 PubMed Central ID: PMC5130580

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The role of proximal versus distal stomach resection in the weight loss seen after vertical sleeve gastrectomy.