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Objective: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer's disease.

Design: Relevant literature was identified through a search of MEDLINE via PubMed using the following words, "n-3 PUFAs," "EPA," and "DHA" in combination with "stress," "cognition," "ADHD," "anxiety," "depression," "bipolar disorder," "schizophrenia," and "Alzheimer." The principal focus was on the role of omega-3 polyunsaturated fatty acids throughout the lifespan and their implication for psychopathologies. Recommendations for future investigation on the potential clinical value of omega-3 polyunsaturated fatty acids were examined.

Results: The inconsistent and inconclusive results from randomized clinical trials limits the usage of omega-3 polyunsaturated fatty acids in clinical practice. However, a body of literature demonstrates an inverse correlation between omega-3 polyunsaturated fatty acid levels and quality of life/ psychiatric diseases. Specifically, older healthy adults showing low habitual intake of omega-3 polyunsaturated fatty acids benefit most from consuming them, showing improved age-related cognitive decline.

Conclusions: Although further studies are required, there is an exciting and growing body of research suggesting that omega-3 polyunsaturated fatty acids may have a potential clinical value in the prevention and treatment of psychopathologies.

Titel:	N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology.
Autor/in / Beteiligte Person:	Pusceddu, MM ; Kelly, P ; Stanton, C ; Cryan, JF ; Dinan, TG
Link:	Full Text Finder (Volltext)
Zeitschrift:	The international journal of neuropsychopharmacology, Jg. 19 (2016-12-30), Heft 12
Veröffentlichung:	2015- : Oxford Oxford University Press ; <i>Original Publication</i>: Cambridge, [England] : Cambridge University Press,, 2016
Medientyp:	academicJournal
ISSN:	1469-5111 (electronic)
DOI:	10.1093/ijnp/pyw078
Schlagwort:	Age Factors Animals Brain metabolism Brain physiopathology Cognition drug effects Humans Mental Disorders metabolism Mental Disorders physiopathology Mental Disorders psychology Protective Factors Risk Factors Aging psychology Brain drug effects Fatty Acids, Omega-3 administration & dosage Feeding Behavior Mental Disorders prevention & control Mental Health
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Int J Neuropsychopharmacol] 2016 Dec 30; Vol. 19 (12). <i>Date of Electronic Publication: </i>2016 Dec 30 (<i>Print Publication: </i>2016). MeSH Terms: Feeding Behavior* ; Mental Health* ; Aging / psychology ; Brain / drug effects ; Fatty Acids, Omega-3 / administration & dosage ; Mental Disorders / prevention & control ; Age Factors ; Animals ; Brain / metabolism ; Brain / physiopathology ; Cognition / drug effects ; Humans ; Mental Disorders / metabolism ; Mental Disorders / physiopathology ; Mental Disorders / psychology ; Protective Factors ; Risk Factors References: Neuropsychopharmacology. 2017 Jan;42(1):81-98. (PMID: 27555379) ; Biol Psychiatry. 2006 Nov 1;60(9):1020-2. (PMID: 16814257) ; J Nutr. 2008 Jun;138(6):1165-71. (PMID: 18492851) ; Am J Clin Nutr. 2012 Dec;96(6):1327-38. (PMID: 23097272) ; Biol Psychiatry. 2014 Oct 1;76(7):559-66. (PMID: 24602409) ; Clin Exp Pharmacol Physiol. 2001 Apr;28(4):266-70. (PMID: 11251638) ; Prostaglandins Leukot Essent Fatty Acids. 2010 Oct-Dec;83(4-6):185-91. (PMID: 20817496) ; J Nutr Biochem. 2005 Sep;16(9):538-46. (PMID: 16115542) ; Curr Neuropharmacol. 2013 Mar;11(2):186-96. (PMID: 23997753) ; Nutr Neurosci. 2010 Aug;13(4):161-9. (PMID: 20670471) ; JAMA. 2009 Oct 21;302(15):1651-7. (PMID: 19843899) ; Transl Psychiatry. 2014 Sep 09;4:e437. (PMID: 25203168) ; Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):329-49. (PMID: 16949263) ; Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):143-9. (PMID: 19201180) ; J Clin Invest. 1996 Feb 15;97(4):1129-33. (PMID: 8613538) ; Am J Psychiatry. 2003 May;160(5):996-8. (PMID: 12727707) ; Alzheimers Dement. 2012 Jul;8(4):278-87. (PMID: 21967845) ; Exp Clin Psychopharmacol. 2012 Jun;20(3):236-42. (PMID: 22250656) ; Biol Psychiatry. 2014 Jan 1;75(1):38-46. (PMID: 23890734) ; Curr Opin Clin Nutr Metab Care. 2007 Mar;10(2):136-41. (PMID: 17285000) ; Neural Plast. 2016;2016:8574830. (PMID: 27057368) ; Am J Clin Nutr. 2009 Jun;89(6):1766-75. (PMID: 19369376) ; PLoS One. 2015 Oct 01;10(10):e0139721. (PMID: 26426902) ; J Neurochem. 2000 Dec;75(6):2563-73. (PMID: 11080210) ; Eur J Clin Invest. 2005 Nov;35(11):691-9. (PMID: 16269019) ; J Am Acad Child Adolesc Psychiatry. 2011 Oct;50(10):991-1000. (PMID: 21961774) ; Pediatr Res. 2005 May;57(5 Pt 1):719-23. (PMID: 15718358) ; Front Cell Neurosci. 2014 Nov 21;8:399. (PMID: 25484856) ; Mol Psychiatry. 2007 Jan;12(1):36-46. (PMID: 16983391) ; Diabetes Metab. 2003 Jun;29(3):289-95. (PMID: 12909818) ; J Physiol Anthropol. 2014 Jul 24;33:22. (PMID: 25060574) ; Biol Psychiatry. 2007 Jul 1;62(1):17-24. (PMID: 17188654) ; Am J Psychiatry. 2003 Jan;160(1):167-9. (PMID: 12505817) ; World J Psychiatry. 2015 Mar 22;5(1):15-34. (PMID: 25815252) ; Biol Psychiatry. 2007 Feb 15;61(4):551-3. (PMID: 16920077) ; Neuropsychopharmacology. 2015 Sep;40(10):2298-306. (PMID: 25790022) ; J Lipid Res. 2008 Feb;49(2):340-8. (PMID: 17991757) ; Biol Psychiatry. 2010 Mar 15;67(6):550-7. (PMID: 20034614) ; J Child Health Care. 2011 Dec;15(4):299-311. (PMID: 21828168) ; Clin Nutr. 2007 Feb;26(1):70-7. (PMID: 17055120) ; Psychiatry Investig. 2010 Dec;7(4):231-5. (PMID: 21253405) ; Nutrients. 2010 Feb;2(2):128-70. (PMID: 22254013) ; J Physiol. 1994 Feb 15;475(1):83-93. (PMID: 7514666) ; Alzheimers Dement. 2010 Nov;6(6):456-64. (PMID: 20434961) ; Brain Behav Immun. 2015 Aug;48:186-94. (PMID: 25882912) ; Am J Clin Nutr. 2009 Feb;89(2):641-51. (PMID: 19116322) ; Am J Psychiatry. 2001 Dec;158(12):2071-4. (PMID: 11729030) ; Prostaglandins Leukot Essent Fatty Acids. 2005 Mar;72(3):211-8. (PMID: 15664306) ; J Neurochem. 2003 Oct;87(2):297-309. (PMID: 14511107) ; J Neurosci. 2002 May 1;22(9):3708-19. (PMID: 11978847) ; Am J Clin Nutr. 2010 Jun;91(6):1725-32. (PMID: 20410089) ; J Clin Psychiatry. 2008 Apr;69(4):644-51. (PMID: 18370571) ; Lancet. 1998 Apr 18;351(9110):1213. (PMID: 9643729) ; Am J Psychiatry. 2006 Jun;163(6):1098-100. (PMID: 16741212) ; J Clin Psychiatry. 2007 Dec;68(12):1867-75. (PMID: 18162017) ; Br J Nutr. 2007 Nov;98(5):873-7. (PMID: 17688705) ; Arch Gen Psychiatry. 2010 Feb;67(2):146-54. (PMID: 20124114) ; Nat Rev Neurosci. 2012 Oct;13(10):701-12. (PMID: 22968153) ; J Neurochem. 2002 Jun;81(5):1084-91. (PMID: 12065621) ; Int J Geriatr Psychiatry. 2008 Feb;23(2):161-9. (PMID: 17582225) ; J Neurosci. 2007 Apr 18;27(16):4385-95. (PMID: 17442823) ; Neurochem Int. 2010 May-Jun;56(6-7):753-9. (PMID: 20172010) ; Brain Behav Immun. 2011 Nov;25(8):1725-34. (PMID: 21784145) ; Res Dev Disabil. 2014 Apr;35(4):861-70. (PMID: 24508294) ; Am J Psychiatry. 2002 Sep;159(9):1596-8. (PMID: 12202284) ; Lipids. 1989 Dec;24(12):1014-9. (PMID: 2615569) ; Neurobiol Aging. 2012 Apr;33(4):824.e1-3. (PMID: 21531481) ; PLoS Biol. 2007 Oct;5(10):2177-89. (PMID: 17760501) ; Br J Psychiatry. 2006 Jan;188:46-50. (PMID: 16388069) ; Br J Nutr. 2012 Jun;107(11):1682-93. (PMID: 21929835) ; Neurobiol Aging. 2007 Mar;28(3):424-39. (PMID: 16500747) ; Subcell Biochem. 2008;49:133-43. (PMID: 18751910) ; J Psychiatr Res. 2002 Jan-Feb;36(1):7-18. (PMID: 11755456) ; Behav Brain Funct. 2012 Dec 10;8:56. (PMID: 23228189) ; J Psychopharmacol. 2007 Jun;21(4):435-9. (PMID: 16891338) ; J Clin Psychiatry. 2011 Dec;72(12):1577-84. (PMID: 21939614) ; J Nutr. 2007 Apr;137(4):855-9. (PMID: 17374644) ; Nutrients. 2014 Apr 23;6(4):1701-10. (PMID: 24763080) ; Int J Neuropsychopharmacol. 2015 Dec 12;19(6):. (PMID: 26657646) ; J Clin Psychiatry. 2015 Jan;76(1):54-61. (PMID: 25272149) ; Br J Nutr. 2012 Apr;107(8):1232-43. (PMID: 21864417) ; Psychoneuroendocrinology. 2015 Aug;58:79-90. (PMID: 25965872) ; Schizophr Res. 2001 Apr 30;49(3):243-51. (PMID: 11356585) ; Am J Clin Nutr. 2013 May;97(5):1134-43. (PMID: 23515006) ; Genome Med. 2016 Apr 06;8(1):36. (PMID: 27048547) ; Pediatrics. 2005 May;115(5):1360-6. (PMID: 15867048) ; Early Hum Dev. 1980 Jun;4(2):131-8. (PMID: 7408743) ; Altern Med Rev. 2003 Nov;8(4):410-25. (PMID: 14653768) ; Am J Psychiatry. 2002 Mar;159(3):477-9. (PMID: 11870016) ; Nutr Neurosci. 2002 Feb;5(1):43-52. (PMID: 11929197) ; Gastroenterol Res Pract. 2011;2011:364040. (PMID: 21197079) ; PLoS One. 2013 Aug 13;8(8):e70645. (PMID: 23967080) ; Cereb Cortex. 2014 Nov;24(11):3059-68. (PMID: 23796946) ; J Nutr Biochem. 2009 Dec;20(12):965-73. (PMID: 18993051) ; Nutrients. 2013 Jul 19;5(7):2777-810. (PMID: 23877090) ; Am J Clin Nutr. 2007 Oct;86(4):1082-93. (PMID: 17921387) ; Lipids. 1991 Jun;26(6):421-5. (PMID: 1881238) ; Nutr J. 2012 Nov 22;11:99. (PMID: 23173831) ; Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1393-6. (PMID: 17659823) ; Early Hum Dev. 1980 Jun;4(2):121-9. (PMID: 7408742) ; Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):1-9. (PMID: 10970706) ; Brain Res. 1995 Jan 16;669(2):225-33. (PMID: 7712178) ; Am J Clin Nutr. 2010 Apr;91(4):1060-7. (PMID: 20130094) ; Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):311-26. (PMID: 18514501) ; Biotechnol J. 2006 Apr;1(4):420-39. (PMID: 16892270) ; Pediatrics. 2003 Jan;111(1):e39-44. (PMID: 12509593) ; Indian J Pediatr. 2005 Mar;72(3):239-42. (PMID: 15812120) ; Arch Neurol. 2003 Jul;60(7):940-6. (PMID: 12873849) ; J Psychopharmacol. 2009 Sep;23(7):831-40. (PMID: 18583436) ; J Neurochem. 2006 Jan;96(2):385-95. (PMID: 16300635) ; J Nutr Biochem. 2010 Apr;21(4):345-50. (PMID: 19423322) ; Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11047-54. (PMID: 11572967) ; Am J Clin Nutr. 2005 Jul;82(1):125-32. (PMID: 16002810) ; Res Dev Disabil. 2010 May-Jun;31(3):718-30. (PMID: 20171055) ; Br J Nutr. 2008 Feb;99(2):421-31. (PMID: 17956647) ; Prog Neuropsychopharmacol Biol Psychiatry. 2002 May;26(4):639-45. (PMID: 12188094) ; Cochrane Database Syst Rev. 2012 Jul 11;(7):CD007986. (PMID: 22786509) ; Neuroscience. 2008 Aug 26;155(3):751-9. (PMID: 18620024) ; Arch Neurol. 2006 Oct;63(10):1402-8. (PMID: 17030655) ; Neurosci Res. 2006 Oct;56(2):159-64. (PMID: 16905216) ; J Dev Behav Pediatr. 2007 Apr;28(2):82-91. (PMID: 17435458) ; Neurobiol Aging. 2011 Dec;32(12):2318.e1-15. (PMID: 20570403) ; J Nutr. 2005 Mar;135(3):549-55. (PMID: 15735092) ; J Nutr. 1998 Dec;128(12):2512-9. (PMID: 9868201) ; Neurobiol Aging. 2007 Jun;28(6):845-55. (PMID: 16714069) ; Dement Geriatr Cogn Disord. 2010;29(5):467-74. (PMID: 20523044) ; Behav Neurosci. 2012 Apr;126(2):361-9. (PMID: 22352789) ; PLoS One. 2013 Jun 24;8(6):e65514. (PMID: 23826081) ; Br J Psychiatry. 2007 Feb;190:118-22. (PMID: 17267927) ; Psychopharmacology (Berl). 2013 Feb;225(3):605-12. (PMID: 22932777) ; Neurobiol Aging. 2002 Sep-Oct;23(5):843-53. (PMID: 12392789) ; Obstet Gynecol. 2003 Mar;101(3):469-79. (PMID: 12636950) ; J Atten Disord. 2009 Mar;12(5):394-401. (PMID: 18448859) ; Brain Res. 2003 Feb 21;964(1):136-43. (PMID: 12573522) ; Eur J Clin Nutr. 2004 Mar;58(3):467-73. (PMID: 14985685) ; Proc Nutr Soc. 2008 Feb;67(1):19-27. (PMID: 18234128) ; J Physiol Biochem. 2012 Dec;68(4):671-81. (PMID: 22707188) ; Hum Psychopharmacol. 2001 Jan;16(1):45-52. (PMID: 12404597) ; Prog Lipid Res. 2009 Nov;48(6):355-74. (PMID: 19619583) ; J Lipid Res. 2006 Mar;47(3):571-81. (PMID: 16352524) ; Neuropharmacology. 2012 Jan;62(1):184-91. (PMID: 21740919) ; Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1538-44. (PMID: 18573585) ; PLoS One. 2012;7(9):e43909. (PMID: 22970149) ; Pediatr Res. 2005 Oct;58(4):741-8. (PMID: 16189203) ; Prostaglandins Leukot Essent Fatty Acids. 2013 Aug;89(2-3):71-9. (PMID: 23756346) ; Lipids. 2004 Dec;39(12):1215-22. (PMID: 15736918) ; Front Cell Neurosci. 2015 Mar 31;9:40. (PMID: 25873859) ; Br J Nutr. 2002 Jan;87 Suppl 1:S59-67. (PMID: 11895155) ; Nutr Neurosci. 2009 Apr;12(2):48-56. (PMID: 19356306) ; Brain Behav Immun. 2017 Jan;59:21-37. (PMID: 27423492) ; Rev Neurosci. 2011;22(3):365-71. (PMID: 21591908) ; Am J Clin Nutr. 2000 Jan;71(1 Suppl):327S-30S. (PMID: 10617991) ; Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5. (PMID: 17699621) ; Biol Psychiatry. 2010 Jul 15;68(2):140-7. (PMID: 20452573) ; Nutr J. 2004 Nov 28;3:20. (PMID: 15566625) ; Brain Behav Immun. 2012 Jul;26(5):721-31. (PMID: 22085587) ; Biol Psychol. 2012 Jan;89(1):183-90. (PMID: 22020134) ; Behav Brain Res. 2011 May 16;219(1):116-22. (PMID: 21192985) ; Arch Gen Psychiatry. 2002 Oct;59(10):913-9. (PMID: 12365878) ; J Neurochem. 2007 May;101(3):577-99. (PMID: 17257165) ; Physiol Rev. 2007 Jul;87(3):873-904. (PMID: 17615391) ; Behav Brain Res. 2004 Jun 4;152(1):49-57. (PMID: 15135968) ; PLoS One. 2012;7(10):e46832. (PMID: 23056476) ; Front Aging Neurosci. 2014 Aug 25;6:220. (PMID: 25202271) ; J Affect Disord. 2002 May;69(1-3):15-29. (PMID: 12103448) ; Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):233-9. (PMID: 11817499) ; Am J Clin Nutr. 2008 Sep;88(3):706-13. (PMID: 18779287) ; J Am Acad Child Adolesc Psychiatry. 2012 Jul;51(7):722-732.e9. (PMID: 22721595) ; J Neurosci. 2005 Mar 23;25(12):3032-40. (PMID: 15788759) ; Arch Gen Psychiatry. 1999 May;56(5):407-12. (PMID: 10232294) ; Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):69-74. (PMID: 10970716) ; J Lipid Res. 2006 Jan;47(1):172-80. (PMID: 16210728) ; J Nutr. 2010 Apr;140(4):848-53. (PMID: 20181791) ; Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71. (PMID: 12888186) ; Am J Clin Nutr. 2011 May;93(5):1025-37. (PMID: 21389181) ; Neurochem Int. 2010 Jan;56(1):94-100. (PMID: 19770016) ; Nutr Neurosci. 2008 Apr;11(2):75-83. (PMID: 18510807) ; Lipids. 1999;34 Suppl:S345-6. (PMID: 10419198) ; Int J Neurosci. 1996 Nov;87(3-4):141-9. (PMID: 9003975) ; Psychiatr Clin North Am. 2013 Mar;36(1):15-23. (PMID: 23538073) ; Neurology. 2008 Aug 5;71(6):430-8. (PMID: 18678826) ; J Pediatr. 2001 Aug;139(2):189-96. (PMID: 11487742) ; Lipids. 2003 Oct;38(10):1007-21. (PMID: 14669965) ; J Lipid Res. 2001 Oct;42(10):1655-63. (PMID: 11590222) ; Am J Clin Nutr. 2001 Feb;73(2):316-22. (PMID: 11157330) ; Early Interv Psychiatry. 2014 Aug;8(3):199-208. (PMID: 24861004) Contributed Indexing: Keywords: Alzheimer’s disease; bipolar disorder; depression; omega-3 polyunsaturated fatty acids (n-3 PUFAs); schizophrenia Substance Nomenclature: 0 (Fatty Acids, Omega-3) Entry Date(s): Date Created: 20160910 Date Completed: 20180108 Latest Revision: 20240324 Update Code: 20240324 PubMed Central ID: PMC5203760

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N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology.