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We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [ 11 C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [ 11 C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.

Competing Interests: Declaration of interest J.T.O.'B. consulted for GE Healthcare, Servier and Bayer Healthcare and has received honoraria for talks from Pfizer, GE Healthcare, Eisai, Shire, Lundbeck, Lilly and Novartis.

Titel:	Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.
Autor/in / Beteiligte Person:	Su, L ; Faluyi, YO ; Hong, YT ; Fryer, TD ; Mak, E ; Gabel, S ; Hayes, L ; Soteriades, S ; Williams, GB ; Arnold, R ; Passamonti, L ; Rodríguez, PV ; Surendranathan, A ; Bevan-Jones, RW ; Coles, J ; Aigbirhio, F ; Rowe, JB ; O'Brien, JT
Link:	Full Text Finder (Volltext)
Zeitschrift:	The British journal of psychiatry : the journal of mental science, Jg. 209 (2016-12-01), Heft 6, S. 525-526
Veröffentlichung:	2019- : [Cambridge] : Cambridge University Press ; <i>Original Publication</i>: London, Headley Brothers., 2016
Medientyp:	academicJournal
ISSN:	1472-1465 (electronic)
DOI:	10.1192/bjp.bp.116.190165
Schlagwort:	Aged Aged, 80 and over Female Hippocampus diagnostic imaging Hippocampus immunology Hippocampus metabolism Hippocampus pathology Humans Magnetic Resonance Imaging Male Multimodal Imaging Positron-Emission Tomography C-Reactive Protein analysis Cerebral Cortex diagnostic imaging Cerebral Cortex immunology Cerebral Cortex metabolism Cerebral Cortex pathology Depressive Disorder, Major blood Depressive Disorder, Major diagnostic imaging Depressive Disorder, Major immunology Depressive Disorder, Major pathology Inflammation diagnostic imaging Inflammation immunology Inflammation metabolism Inflammation pathology Receptors, GABA metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Br J Psychiatry] 2016 Dec; Vol. 209 (6), pp. 525-526. <i>Date of Electronic Publication: </i>2016 Oct 06. MeSH Terms: Cerebral Cortex* / diagnostic imaging ; Cerebral Cortex* / immunology ; Cerebral Cortex* / metabolism ; Cerebral Cortex* / pathology ; Depressive Disorder, Major* / blood ; Depressive Disorder, Major* / diagnostic imaging ; Depressive Disorder, Major* / immunology ; Depressive Disorder, Major* / pathology ; Inflammation* / diagnostic imaging ; Inflammation* / immunology ; Inflammation* / metabolism ; Inflammation* / pathology ; C-Reactive Protein / analysis ; Receptors, GABA / metabolism ; Aged ; Aged, 80 and over ; Female ; Hippocampus / diagnostic imaging ; Hippocampus / immunology ; Hippocampus / metabolism ; Hippocampus / pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Multimodal Imaging ; Positron-Emission Tomography References: Am J Geriatr Psychiatry. 2014 Dec;22(12):1504-12. (PMID: 24378256) ; Endocr Rev. 1986 Aug;7(3):284-301. (PMID: 3527687) ; Arch Neurol. 2006 May;63(5):693-9. (PMID: 16682538) ; Am J Psychiatry. 2005 Jan;162(1):175-7. (PMID: 15625217) ; J Cereb Blood Flow Metab. 2012 Aug;32(8):1600-8. (PMID: 22588187) ; Arch Gen Psychiatry. 1997 Oct;54(10):915-22. (PMID: 9337771) ; Nat Rev Neurosci. 2008 Jan;9(1):46-56. (PMID: 18073775) ; Br J Psychiatry. 2012 Jul;201(1):46-51. (PMID: 22753853) ; J Psychiatr Res. 1975 Nov;12(3):189-98. (PMID: 1202204) ; Br J Psychiatry. 1979 Apr;134:382-9. (PMID: 444788) ; Biol Psychiatry. 2006 Dec 15;60(12):1356-63. (PMID: 16876144) ; J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):21-8. (PMID: 26384512) Grant Information: 103838 United Kingdom WT_ Wellcome Trust; 093875 United Kingdom Wellcome Trust; MR/M009041/1 United Kingdom MRC_ Medical Research Council; MC_U105597119 United Kingdom MRC_ Medical Research Council; MR/M024873/1 United Kingdom MRC_ Medical Research Council Substance Nomenclature: 0 (Receptors, GABA) ; 0 (TSPO protein, human) ; 9007-41-4 (C-Reactive Protein) Entry Date(s): Date Created: 20161021 Date Completed: 20170904 Latest Revision: 20220318 Update Code: 20240513 PubMed Central ID: PMC5152879

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Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.