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Mycobacterium tuberculosis is the causal agent of tuberculosis. Tumor necrosis factor alpha (TNF-α), transforming growth factor β (TGF-β), and gamma interferon (IFN-γ) secreted by activated macrophages and lymphocytes are considered essential to contain Mycobacterium tuberculosis infection. The CD43 sialomucin has been reported to act as a receptor for bacilli through its interaction with the chaperonin Cpn60.2, facilitating mycobacterium-macrophage contact. We report here that Cpn60.2 induces both human THP-1 cells and mouse-derived bone marrow-derived macrophages (BMMs) to produce TNF-α and that this production is CD43 dependent. In addition, we present evidence that the signaling pathway leading to TNF-α production upon interaction with Cpn60.2 requires active Src family kinases, phospholipase C-γ (PLC-γ), phosphatidylinositol 3-kinase (PI3K), p38, and Jun N-terminal protein kinase (JNK), both in BMMs and in THP-1 cells. Our data highlight the role of CD43 and Cpn60.2 in TNF-α production and underscore an important role for CD43 in the host-mycobacterium interaction.

Titel:	Interaction of the CD43 Sialomucin with the Mycobacterium tuberculosis Cpn60.2 Chaperonin Leads to Tumor Necrosis Factor Alpha Production.
Autor/in / Beteiligte Person:	Torres-Huerta, A ; Villaseñor, T ; Flores-Alcantar, A ; Parada, C ; Alemán-Navarro, E ; Espitia, C ; Pedraza-Alva, G ; Rosenstein, Y
Link:	Full Text Finder (Volltext)
Zeitschrift:	Infection and immunity, Jg. 85 (2017-02-23), Heft 3
Veröffentlichung:	Washington, DC : American Society For Microbiology ; <i>Original Publication</i>: [Bethesda, Md.] American Society for Microbiology., 2017
Medientyp:	academicJournal
ISSN:	1098-5522 (electronic)
DOI:	10.1128/IAI.00915-16
Schlagwort:	Cell Line Humans Macrophages immunology Macrophages metabolism Macrophages microbiology NF-kappa B metabolism Protein Binding Signal Transduction Transcription Factor AP-1 metabolism Bacterial Proteins metabolism Chaperonin 60 metabolism Leukosialin metabolism Mycobacterium tuberculosis physiology Tumor Necrosis Factor-alpha biosynthesis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Infect Immun] 2017 Feb 23; Vol. 85 (3). <i>Date of Electronic Publication: </i>2017 Feb 23 (<i>Print Publication: </i>2017). MeSH Terms: Bacterial Proteins / metabolism ; Chaperonin 60 / metabolism ; Leukosialin / metabolism ; Mycobacterium tuberculosis / physiology ; Tumor Necrosis Factor-alpha / *biosynthesis ; Cell Line ; Humans ; Macrophages / immunology ; Macrophages / metabolism ; Macrophages / microbiology ; NF-kappa B / metabolism ; Protein Binding ; Signal Transduction ; Transcription Factor AP-1 / metabolism References: J Leukoc Biol. 2001 Jun;69(6):1036-44. (PMID: 11404392) ; Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):361-99. (PMID: 24915502) ; J Biol Chem. 2001 Jan 5;276(1):729-37. (PMID: 11024037) ; PLoS One. 2013 Jul 15;8(7):e68680. (PMID: 23869227) ; Mol Pharmacol. 1999 Mar;55(3):481-8. (PMID: 10051531) ; Am J Respir Cell Mol Biol. 2015 Mar;52(3):342-8. (PMID: 25078322) ; Nat Immunol. 2011 Jul 19;12(8):695-708. (PMID: 21772278) ; Immune Netw. 2011 Apr;11(2):123-33. (PMID: 21637390) ; Nature. 1991 Nov 21;354(6350):233-5. (PMID: 1683685) ; J Biol Chem. 2007 Jan 12;282(2):1039-50. (PMID: 17095513) ; Infect Immun. 2006 Jul;74(7):3693-706. (PMID: 16790742) ; Clin Microbiol Rev. 2003 Jul;16(3):463-96. (PMID: 12857778) ; Curr Opin Infect Dis. 2008 Jun;21(3):279-86. (PMID: 18448973) ; J Exp Med. 1975 Jul 1;142(1):1-16. (PMID: 807671) ; Int Immunopharmacol. 2007 Feb;7(2):230-40. (PMID: 17178391) ; FEMS Microbiol Lett. 2005 May 15;246(2):221-8. (PMID: 15899409) ; J Leukoc Biol. 1994 Apr;55(4):536-44. (PMID: 8145025) ; J Immunol. 2001 Mar 15;166(6):3637-40. (PMID: 11238599) ; Biomed Res Int. 2013;2013:179174. (PMID: 24350246) ; Curr Drug Targets. 2008 Feb;9(2):102-12. (PMID: 18288961) ; Cell Microbiol. 2008 Sep;10(9):1893-905. (PMID: 18503635) ; J Exp Med. 1996 Nov 1;184(5):1769-79. (PMID: 8920865) ; Front Cell Infect Microbiol. 2012 Nov 23;2:145. (PMID: 23189273) ; J Immunol. 1990 Apr 1;144(7):2771-80. (PMID: 2108212) ; J Immunol. 1995 Dec 1;155(11):5343-51. (PMID: 7594549) ; Cell Microbiol. 2007 Feb;9(2):382-96. (PMID: 16925784) ; J Immunol. 2005 Dec 15;175(12):8042-50. (PMID: 16339541) ; J Immunol. 1999 Jul 1;163(1):312-21. (PMID: 10384130) ; Infect Immun. 2008 Apr;76(4):1535-46. (PMID: 18227175) ; J Immunol. 1998 Aug 1;161(3):1414-21. (PMID: 9686605) ; Infect Immun. 2001 Dec;69(12):7349-55. (PMID: 11705907) ; J Biol Chem. 1988 Oct 15;263(29):15146-50. (PMID: 2971663) ; Tuberculosis (Edinb). 2010 Mar;90(2):119-24. (PMID: 20338810) ; Enzyme Res. 2011;2011:537821. (PMID: 21876792) ; EMBO J. 1991 Apr;10(4):893-902. (PMID: 1706994) ; Mol Cell Biochem. 2008 Nov;318(1-2):167-74. (PMID: 18649046) ; Immunol Today. 1998 Dec;19(12):546-50. (PMID: 9864944) ; Cell Death Differ. 2000 Dec;7(12):1270-2. (PMID: 11270362) ; Infect Immun. 1995 Apr;63(4):1598-602. (PMID: 7534279) ; Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii54-8. (PMID: 12379623) ; Eur J Immunol. 2000 Feb;30(2):594-603. (PMID: 10671216) ; Science. 2002 Apr 19;296(5567):550-3. (PMID: 11910072) ; Clin Exp Immunol. 1993 Jan;91(1):58-62. (PMID: 8419086) ; Cell Microbiol. 2010 Nov;12(11):1634-47. (PMID: 20633027) ; J Immunol. 1993 Apr 1;150(7):2920-30. (PMID: 8454864) ; Infect Immun. 2001 Sep;69(9):5606-11. (PMID: 11500435) ; Infect Immun. 2009 Aug;77(8):3389-401. (PMID: 19470749) ; Med Biol. 1986;64(6):335-43. (PMID: 2950285) ; PLoS One. 2013 Nov 18;8(11):e80806. (PMID: 24260485) ; Crit Rev Microbiol. 2012 Aug;38(3):250-66. (PMID: 22324751) ; J Immunol. 2006 Oct 15;177(8):5328-36. (PMID: 17015718) ; Curr Protoc Immunol. 2002 Aug;Chapter 5:Unit 5.4. (PMID: 18432885) ; Front Microbiol. 2011 Jan 26;2:2. (PMID: 21687401) ; Infect Immun. 2001 Dec;69(12):7326-33. (PMID: 11705904) ; J Exp Med. 2000 Jul 17;192(2):183-92. (PMID: 10899905) ; J Immunol. 1999 Jan 1;162(1):415-22. (PMID: 9886415) ; Clin Exp Immunol. 1992 Aug;89(2):305-9. (PMID: 1638774) ; Cell Microbiol. 2003 Mar;5(3):133-42. (PMID: 12614457) ; Vaccine. 2007 Jan 22;25(6):1096-103. (PMID: 17049413) ; J Immunol. 2005 Aug 1;175(3):1805-12. (PMID: 16034122) ; Front Immunol. 2013 Feb 14;4:30. (PMID: 23420646) ; Infect Immun. 2010 Jul;78(7):3196-206. (PMID: 20421377) ; Cell Microbiol. 2008 Oct;10(10):2105-17. (PMID: 18637079) ; J Leukoc Biol. 2004 Apr;75(4):689-97. (PMID: 14742634) ; J Immunol. 2002 Jan 15;168(2):569-76. (PMID: 11777948) Contributed Indexing: Keywords: CD43; Cpn60.2; Mycobacterium tuberculosis; cell signaling; macrophages; tumor necrosis factor alpha Substance Nomenclature: 0 (Bacterial Proteins) ; 0 (Chaperonin 60) ; 0 (Leukosialin) ; 0 (NF-kappa B) ; 0 (Transcription Factor AP-1) ; 0 (Tumor Necrosis Factor-alpha) Entry Date(s): Date Created: 20170111 Date Completed: 20170516 Latest Revision: 20190329 Update Code: 20240513 PubMed Central ID: PMC5328480

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Interaction of the CD43 Sialomucin with the Mycobacterium tuberculosis Cpn60.2 Chaperonin Leads to Tumor Necrosis Factor Alpha Production.