Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) enhances testicular gene expression of 3β-hydroxysteroid dehydrogenase in rats.

Ohta, Y ; Kawate, N ; et al.

In: Andrologia, Jg. 49 (2017-12-01), Heft 10

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Although feeding diets containing the extract powder of Lepidium meyenii (maca), a plant growing in Peru's Central Andes, increases serum testosterone concentration associated with enhanced ability of testosterone production by Leydig cells in male rats, changes in testicular steroidogenesis-related factors by the maca treatment are not known. This study examined the effects of maca on testicular gene expressions for luteinizing hormone receptor, steroidogenic acute regulatory protein and steroidogenic enzymes. Eight-week-old male rats were given the diets with or without (control) the maca extract powder (2%) for 6 weeks, and mRNA levels were determined by reverse transcription quantitative real-time PCR. The results showed that the testicular mRNA level of HSD3B1 (3β-hydroxysteroid dehydrogenase; 3β-HSD) increased by the treatment, whereas the levels of the other factors examined did not change. These results suggest that increased expression of 3β-HSD gene may be involved in the enhanced steroidogenic ability by the maca treatment in rat testes.

Titel:	Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) enhances testicular gene expression of 3β-hydroxysteroid dehydrogenase in rats.
Autor/in / Beteiligte Person:	Ohta, Y ; Kawate, N ; Inaba, T ; Morii, H ; Takahashi, K ; Tamada, H
Link:	Full Text Finder (Volltext)
Zeitschrift:	Andrologia, Jg. 49 (2017-12-01), Heft 10
Veröffentlichung:	<Feb. 2004-> : Berlin : Blackwell Pub. ; <i>Original Publication</i>: Berlin, Grosse, 2017
Medientyp:	academicJournal
ISSN:	1439-0272 (electronic)
DOI:	10.1111/and.12792
Schlagwort:	17-Hydroxysteroid Dehydrogenases metabolism Animals Leydig Cells drug effects Male Phosphoproteins genetics Phosphoproteins metabolism Rats Receptors, LH genetics Receptors, LH metabolism Spermatogenesis drug effects Testis metabolism 17-Hydroxysteroid Dehydrogenases genetics Gene Expression drug effects Lepidium Plant Extracts pharmacology Testis drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Andrologia] 2017 Dec; Vol. 49 (10). <i>Date of Electronic Publication: </i>2017 Mar 06. MeSH Terms: Lepidium* ; 17-Hydroxysteroid Dehydrogenases / genetics ; Gene Expression / drug effects ; Plant Extracts / pharmacology ; Testis / drug effects ; 17-Hydroxysteroid Dehydrogenases / metabolism ; Animals ; Leydig Cells / drug effects ; Male ; Phosphoproteins / genetics ; Phosphoproteins / metabolism ; Rats ; Receptors, LH / genetics ; Receptors, LH / metabolism ; Spermatogenesis / drug effects ; Testis / metabolism Contributed Indexing: Keywords: 3β-HSD; maca; rat; testis Substance Nomenclature: 0 (Phosphoproteins) ; 0 (Plant Extracts) ; 0 (Receptors, LH) ; 0 (steroidogenic acute regulatory protein) ; EC 1.1.- (17-Hydroxysteroid Dehydrogenases) ; EC 1.1.1.51 (3 (or 17)-beta-hydroxysteroid dehydrogenase) Entry Date(s): Date Created: 20170307 Date Completed: 20180702 Latest Revision: 20180702 Update Code: 20240513

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