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Ovalbumin-induced allergic lung inflammation (ALI) is a condition believed to be mediated by cytokines, extracellular matrix remodeling, and redox imbalance. In this study, we evaluated pulmonary function together with inflammatory markers as interleukin-4 (IL-4), myeloperoxidase (MPO), eosinophil cells, and redox markers in the lungs of BALB/c mice after ovalbumin (OVA) sensitization and challenge. Our results showed an increase in bronchial hyperresponsiveness stimulated by methacholine (Mch), inflammatory cell influx, especially eosinophils together with an increase of high mobility group box 1 (HMGB1) and altered lipid peroxidation (LP) and antioxidant defenses in the OVA group compared to the control group (p ≤ 0.5). Thus, we demonstrated that OVA-induced ALI altered redox status concomitantly with impaired lung function, which was associated with HMGB1 expression and proteolytic remodeling. Taken together all results found here, we may suggest HMGB1 is an important therapeutic target for asthma, once orchestrates the redox signaling, inflammation, and remodeling that contribute to the disease development.

Titel:	Inflammatory and Oxidative Stress Markers in Experimental Allergic Asthma.
Autor/in / Beteiligte Person:	Nesi, RT ; Kennedy-Feitosa, E ; Lanzetti, M ; Ávila, MB ; Magalhães, CB ; Zin, WA ; Faffe, DS ; Porto, LC ; Valença, SS
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammation, Jg. 40 (2017-08-01), Heft 4, S. 1166-1176
Veröffentlichung:	1999- : New York, NY : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York, Plenum Press., 2017
Medientyp:	academicJournal
ISSN:	1573-2576 (electronic)
DOI:	10.1007/s10753-017-0560-2
Schlagwort:	Animals Biomarkers analysis Bronchial Hyperreactivity Eosinophils Lipid Peroxidation Mice Mice, Inbred BALB C Ovalbumin immunology Proteolysis Asthma metabolism Asthma pathology HMGB1 Protein metabolism Inflammation diagnosis Inflammation immunology Oxidative Stress immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Inflammation] 2017 Aug; Vol. 40 (4), pp. 1166-1176. MeSH Terms: Inflammation* / diagnosis ; Inflammation* / immunology ; Oxidative Stress* / immunology ; Asthma / metabolism ; Asthma / pathology ; HMGB1 Protein / *metabolism ; Animals ; Biomarkers / analysis ; Bronchial Hyperreactivity ; Eosinophils ; Lipid Peroxidation ; Mice ; Mice, Inbred BALB C ; Ovalbumin / immunology ; Proteolysis References: Respir Med. 2011 Apr;105(4):519-25. (PMID: 21041074) ; Int Arch Allergy Immunol. 1997 Nov;114(3):207-17. (PMID: 9363900) ; Chest. 2012 Apr;141(4):1055-1062. (PMID: 22474147) ; J Immunol. 1999 Apr 1;162(7):4212-9. (PMID: 10201949) ; Int Arch Allergy Immunol. 1993;102(4):368-74. (PMID: 8241799) ; Scand J Infect Dis. 2003;35(9):577-84. (PMID: 14620138) ; Respir Physiol Neurobiol. 2009 Feb 28;165(2-3):202-7. (PMID: 19135181) ; J Thorac Dis. 2015 Oct;7(10):1732-41. 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Inflammatory and Oxidative Stress Markers in Experimental Allergic Asthma.