Use of a 17-Gene Prognostic Assay in Contemporary Urologic Practice: Results of an Interim Analysis in an Observational Cohort.
In: Urology, Jg. 107 (2017-09-01), S. 67-75
academicJournal
Zugriff:
Objective: To study the impact of genomic testing in shared decision making for men with clinically low-risk prostate cancer (PCa).
Materials and Methods: Patients with clinically low-risk PCa were enrolled in a prospective, multi-institutional study of a validated 17-gene tissue-based reverse transcription polymerase chain reaction assay (Genomic Prostate Score [GPS]). In this paper we report on outcomes in the first 297 patients enrolled in the study with valid 17-gene assay results and decision-change data. The primary end points were shared decision on initial management and persistence on active surveillance (AS) at 1 year post diagnosis. AS utilization and persistence were compared with similar end points in a group of patients who did not have genomic testing (baseline cohort). Secondary end points included perceived utility of the assay and patient decisional conflict before and after testing.
Results: One-year results were available on 258 patients. Shift between initial recommendation and shared decision occurred in 23% of patients. Utilization of AS was higher in the GPS-tested cohort than in the untested baseline cohort (62% vs 40%). The proportion of men who selected and persisted on AS at 1 year was 55% and 34% in the GPS and baseline cohorts, respectively. Physicians reported that GPS was useful in 90% of cases. Mean decisional conflict scores declined in patients after GPS testing.
Conclusion: Patients who received GPS testing were more likely to select and persist on AS for initial management compared with a matched baseline group. These data indicate that GPS help guide shared decisions in clinically low-risk PCa.
(Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
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Use of a 17-Gene Prognostic Assay in Contemporary Urologic Practice: Results of an Interim Analysis in an Observational Cohort.
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Autor/in / Beteiligte Person: | Eure, G ; Germany, R ; Given, R ; Lu, R ; Shindel, AW ; Rothney, M ; Glowacki, R ; Henderson, J ; Richardson, T ; Goldfischer, E ; Febbo, PG ; Denes, BS |
Zeitschrift: | Urology, Jg. 107 (2017-09-01), S. 67-75 |
Veröffentlichung: | New York : Elsevier Science ; <i>Original Publication</i>: Ridgewood, N.J., Professional Medical Services Co., 2017 |
Medientyp: | academicJournal |
ISSN: | 1527-9995 (electronic) |
DOI: | 10.1016/j.urology.2017.02.052 |
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