Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants.
In: International journal of obesity (2005), Jg. 41 (2017-12-01), Heft 12, S. 1761-1768
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Zugriff:
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study.
Methods: This study included cross-sectional data from 48 170 white European adults, aged 37-73 years, participating in the UK Biobank. Interactions between GPRS-obesity and macronutrient intake (including total energy, protein, fat, carbohydrate and dietary fibre intake) and its effects on BMI and WC were investigated.
Results: The 93-single-nucleotide polymorphism (SNP) GPRS was associated with a higher BMI (β: 0.57 kg m - 2 per s.d. increase in GPRS (95% confidence interval: 0.53-0.60); P=1.9 × 10 -183 ) independent of major confounding factors. There was a significant interaction between GPRS and total fat intake (P ( interaction) =0.007). Among high-fat-intake individuals, BMI was higher by 0.60 (0.52, 0.67) kg m -2 per s.d. increase in GPRS-obesity; the change in BMI with GPRS was lower among low-fat-intake individuals (β: 0.50 (0.44, 0.57) kg m -2 ). Significant interactions with similar patterns were observed for saturated fat intake (high β: 0.66 (0.59, 0.73) versus low β: 0.49 (0.42, 0.55) kg m -2 , P ( interaction) =2 × 10 -4 ) and for total energy intake (high β: 0.58 (0.51, 0.64) versus low β: 0.49 (0.42, 0.56) kg m -2 , P ( interaction) =0.019), but not for protein intake, carbohydrate intake and fibre intake (P ( interaction) >0.05). The findings were broadly similar using WC as the outcome.
Conclusions: These data suggest that the benefits of reducing the intake of fats and total energy intake may be more important in individuals with high genetic risk for obesity.
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Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants.
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Autor/in / Beteiligte Person: | Celis-Morales, CA ; Lyall, DM ; Gray, SR ; Steell, L ; Anderson, J ; Iliodromiti, S ; Welsh, P ; Guo, Y ; Petermann, F ; Mackay, DF ; Bailey, MES ; Pell, JP ; Gill, JMR ; Sattar, N |
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Zeitschrift: | International journal of obesity (2005), Jg. 41 (2017-12-01), Heft 12, S. 1761-1768 |
Veröffentlichung: | London : Nature Pub. Group, c2005-, 2017 |
Medientyp: | academicJournal |
ISSN: | 1476-5497 (electronic) |
DOI: | 10.1038/ijo.2017.169 |
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