Einzeltreffer — DigiBib

The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) is highly expressed in monocytes/macrophages. However, its roles in monopoiesis are largely unknown. Here, we investigated the roles of C/EBPβ in monopoiesis. Further subdivision of monocytes revealed that Cebpb messenger RNA was highly upregulated in Ly6C - monocytes in bone marrow. Accordingly, the number of Ly6C - monocytes was significantly reduced in Cebpb -/- mice. Bone marrow chimera experiments and Mx1 -Cre-mediated deletion of Cebpb revealed a cell-intrinsic and monocyte-specific requirement for C/EBPβ in monopoiesis. In Cebpb -/- mice, turnover of Ly6C - monocytes was highly accelerated and apoptosis of Ly6C - monocytes was increased. Expression of Csf1r , which encodes a receptor for macrophage colony-stimulating factor, was significantly reduced in Ly6C - monocytes of Cebpb -/- mice. C/EBPβ bound to positive regulatory elements of Csf1r and promoted its transcription. Collectively, these results indicate that C/EBPβ is a critical factor for Ly6C - monocyte survival, at least in part through upregulation of Csf1r.

Titel:	C/EBPβ is required for survival of Ly6C <superscript>-</superscript> monocytes.
Autor/in / Beteiligte Person:	Tamura, A ; Hirai, H ; Yokota, A ; Kamio, N ; Sato, A ; Shoji, T ; Kashiwagi, T ; Torikoshi, Y ; Miura, Y ; Tenen, DG ; Maekawa, T
Link:	Full Text Finder (Volltext)
Zeitschrift:	Blood, Jg. 130 (2017-10-19), Heft 16, S. 1809-1818
Veröffentlichung:	2021- : [New York] : Elsevier ; <i>Original Publication</i>: New York, Grune & Stratton [etc.], 2017
Medientyp:	academicJournal
ISSN:	1528-0020 (electronic)
DOI:	10.1182/blood-2017-03-772962
Schlagwort:	Animals Antigens, Ly metabolism CCAAT-Enhancer-Binding Protein-beta genetics COS Cells Cell Differentiation genetics Cell Survival genetics Cells, Cultured Chlorocebus aethiops Gene Expression Regulation Mice Mice, Knockout Monocytes metabolism Receptors, Granulocyte-Macrophage Colony-Stimulating Factor genetics Receptors, Granulocyte-Macrophage Colony-Stimulating Factor physiology Apoptosis genetics CCAAT-Enhancer-Binding Protein-beta physiology Monocytes physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Blood] 2017 Oct 19; Vol. 130 (16), pp. 1809-1818. <i>Date of Electronic Publication: </i>2017 Aug 14. MeSH Terms: Apoptosis / genetics ; CCAAT-Enhancer-Binding Protein-beta / physiology ; Monocytes / *physiology ; Animals ; Antigens, Ly / metabolism ; CCAAT-Enhancer-Binding Protein-beta / genetics ; COS Cells ; Cell Differentiation / genetics ; Cell Survival / genetics ; Cells, Cultured ; Chlorocebus aethiops ; Gene Expression Regulation ; Mice ; Mice, Knockout ; Monocytes / metabolism ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / genetics ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / physiology References: J Biol Chem. 2007 Jul 27;282(30):21924-33. (PMID: 17540774) ; Int J Clin Exp Pathol. 2012;5(9):863-73. (PMID: 23119103) ; J Immunol. 2008 Apr 15;180(8):5645-52. (PMID: 18390749) ; Eur J Immunol. 2013 Jun;43(6):1667-75. (PMID: 23519784) ; J Immunol Methods. 2013 Apr 30;390(1-2):1-8. (PMID: 21466808) ; Mol Cell Biol. 1996 Mar;16(3):1231-40. (PMID: 8622667) ; Immunity. 2013 Jan 24;38(1):79-91. (PMID: 23273845) ; Front Immunol. 2015 Aug 17;6:423. (PMID: 26347746) ; Blood. 2013 Mar 7;121(10):1839-49. (PMID: 23319570) ; Cancer Sci. 2015 Jul;106(7):797-802. (PMID: 25940801) ; Nat Immunol. 2006 Mar;7(3):311-7. (PMID: 16462739) ; Science. 2010 Feb 5;327(5966):656-61. (PMID: 20133564) ; Science. 2007 Aug 3;317(5838):666-70. (PMID: 17673663) ; Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1306-16. (PMID: 25838429) ; Nature. 2017 Jan 5;541(7635):96-101. (PMID: 28002407) ; Genes Dev. 1994 Dec 1;8(23):2831-41. (PMID: 7995521) ; Nature. 2000 Mar 9;404(6774):193-7. (PMID: 10724173) ; Immunity. 2013 Apr 18;38(4):792-804. (PMID: 23601688) ; Mol Ther Methods Clin Dev. 2014 Apr 09;1:14010. (PMID: 26015955) ; Int Immunol. 2009 Sep;21(9):1079-88. (PMID: 19651644) ; Blood. 2012 May 31;119(22):5329-30. (PMID: 22653956) ; J Immunol. 2004 Apr 1;172(7):4410-7. (PMID: 15034056) ; Gene Ther. 2000 Jun;7(12):1063-6. (PMID: 10871756) ; Nature. 1990 May 31;345(6274):442-4. (PMID: 2188141) ; Leukemia. 2013 Mar;27(3):619-28. (PMID: 22948537) ; Blood. 2009 Jan 22;113(4):963-72. (PMID: 18971423) ; J Leukoc Biol. 2007 Mar;81(3):584-92. (PMID: 17135573) ; Arch Immunol Ther Exp (Warsz). 2003;51(3):169-77. (PMID: 12894871) ; Cell. 2004 May 28;117(5):663-76. (PMID: 15163413) ; EMBO J. 2003 Nov 3;22(21):5806-16. (PMID: 14592978) ; Immunity. 2014 Jul 17;41(1):104-15. (PMID: 25035955) ; Mol Cell. 2014 Dec 18;56(6):749-62. (PMID: 25453760) ; Biochem Biophys Res Commun. 2015 Aug 21;464(2):654-8. (PMID: 26168729) ; Immunity. 2017 May 16;46(5):849-862.e7. (PMID: 28514690) ; J Immunol. 2015 Jul 1;195(1):134-44. (PMID: 26019271) ; Cell. 2013 Apr 11;153(2):362-75. (PMID: 23582326) ; J Exp Med. 2007 Jan 22;204(1):171-80. (PMID: 17190836) ; Science. 2006 Jan 6;311(5757):83-7. (PMID: 16322423) ; J Immunol. 2013 Nov 1;191(9):4665-75. (PMID: 24078688) ; Immunity. 2003 Jul;19(1):71-82. (PMID: 12871640) ; Cell. 1995 Jan 27;80(2):353-61. (PMID: 7530603) ; J Exp Med. 2007 Nov 26;204(12):3037-47. (PMID: 18025128) ; Nat Immunol. 2013 Aug;14(8):821-30. (PMID: 23812096) ; Mol Cell Biol. 1994 Dec;14(12):8085-95. (PMID: 7969146) ; Nat Immunol. 2006 Jul;7(7):732-9. (PMID: 16751774) ; Front Biosci. 2008 Jan 01;13:549-60. (PMID: 17981568) ; J Immunol. 2012 Nov 1;189(9):4546-55. (PMID: 23024276) ; Mol Cell Biol. 1993 Jun;13(6):3191-201. (PMID: 8497248) ; Immunity. 2010 Sep 24;33(3):375-86. (PMID: 20832340) ; J Leukoc Biol. 2001 Nov;70(5):812-20. (PMID: 11698502) ; Blood. 2002 Jan 1;99(1):111-20. (PMID: 11756160) ; Immunity. 2011 Dec 23;35(6):932-44. (PMID: 22169040) ; Nat Immunol. 2011 Jul 03;12(8):778-85. (PMID: 21725321) Grant Information: P01 CA066996 United States CA NCI NIH HHS; P01 HL131477 United States HL NHLBI NIH HHS; R35 CA197697 United States CA NCI NIH HHS Substance Nomenclature: 0 (Antigens, Ly) ; 0 (CCAAT-Enhancer-Binding Protein-beta) ; 0 (Csf1r protein, mouse) ; 0 (Ly-6C antigen, mouse) ; 0 (Receptors, Granulocyte-Macrophage Colony-Stimulating Factor) Entry Date(s): Date Created: 20170816 Date Completed: 20171031 Latest Revision: 20210513 Update Code: 20231215 PubMed Central ID: PMC5649551

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

C/EBPβ is required for survival of Ly6C <superscript>-</superscript> monocytes.