Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy.
In: Diabetes & metabolic syndrome, Jg. 12 (2018-04-01), Heft 2, S. 203-206
academicJournal
Zugriff:
An 83-year-old man developed hypoglycemia after undergoing total gastrectomy for gastric cancer in 200X-4. The patient was admitted to our hospital in May 200X and placed on continuous glucose monitoring (CGM). Glycemic excursions were examined while on 3-meal/day (1700kcal) and 6-meal/day (1800kcal) diets. Oxyhyperglycemia followed about 2h later by a sudden drop in glucose levels was seen with both regimens. These findings were consistent with late dumping syndrome. CGM was continued, oral miglitol at 150mg/day or sitagliptin at 50mg/day was started, and glycemic excursions were compared. Results were similar for both drugs, with reductions in postprandial glucose elevations. Meal tolerance testing 3 months after oral sitagliptin, compared to before starting treatment, showed reductions in both early postprandial hyperglycemia and insulin hypersecretion. These findings suggest that DPP-4 inhibitors such as sitagliptin may be effective for treating post-gastrectomy late dumping syndrome.
(Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
Titel: |
Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy.
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Autor/in / Beteiligte Person: | Kurihara, K ; Tamai, A ; Yoshida, Y ; Yakushiji, Y ; Ueno, H ; Fukumoto, M ; Hosoi, M |
Zeitschrift: | Diabetes & metabolic syndrome, Jg. 12 (2018-04-01), Heft 2, S. 203-206 |
Veröffentlichung: | Amsterdam : Elsevier Ltd., 2018 |
Medientyp: | academicJournal |
ISSN: | 1878-0334 (electronic) |
DOI: | 10.1016/j.dsx.2017.11.001 |
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