Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy.

Kurihara, K ; Tamai, A ; et al.

In: Diabetes & metabolic syndrome, Jg. 12 (2018-04-01), Heft 2, S. 203-206

academicJournal

An 83-year-old man developed hypoglycemia after undergoing total gastrectomy for gastric cancer in 200X-4. The patient was admitted to our hospital in May 200X and placed on continuous glucose monitoring (CGM). Glycemic excursions were examined while on 3-meal/day (1700kcal) and 6-meal/day (1800kcal) diets. Oxyhyperglycemia followed about 2h later by a sudden drop in glucose levels was seen with both regimens. These findings were consistent with late dumping syndrome. CGM was continued, oral miglitol at 150mg/day or sitagliptin at 50mg/day was started, and glycemic excursions were compared. Results were similar for both drugs, with reductions in postprandial glucose elevations. Meal tolerance testing 3 months after oral sitagliptin, compared to before starting treatment, showed reductions in both early postprandial hyperglycemia and insulin hypersecretion. These findings suggest that DPP-4 inhibitors such as sitagliptin may be effective for treating post-gastrectomy late dumping syndrome.

Titel:	Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy.
Autor/in / Beteiligte Person:	Kurihara, K ; Tamai, A ; Yoshida, Y ; Yakushiji, Y ; Ueno, H ; Fukumoto, M ; Hosoi, M
Zeitschrift:	Diabetes & metabolic syndrome, Jg. 12 (2018-04-01), Heft 2, S. 203-206
Veröffentlichung:	Amsterdam : Elsevier Ltd., 2018
Medientyp:	academicJournal
ISSN:	1878-0334 (electronic)
DOI:	10.1016/j.dsx.2017.11.001
Schlagwort:	Aged, 80 and over Dumping Syndrome diagnosis Dumping Syndrome etiology Humans Male Postoperative Complications diagnosis Postoperative Complications etiology Treatment Outcome Dipeptidyl-Peptidase IV Inhibitors therapeutic use Dumping Syndrome drug therapy Gastrectomy adverse effects Postoperative Complications drug therapy Sitagliptin Phosphate therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Case Reports; Journal Article Language: English [Diabetes Metab Syndr] 2018 Apr - Jun; Vol. 12 (2), pp. 203-206. <i>Date of Electronic Publication: </i>2017 Nov 29. MeSH Terms: Dipeptidyl-Peptidase IV Inhibitors / therapeutic use ; Dumping Syndrome / drug therapy ; Gastrectomy / adverse effects ; Postoperative Complications / drug therapy ; Sitagliptin Phosphate / *therapeutic use ; Aged, 80 and over ; Dumping Syndrome / diagnosis ; Dumping Syndrome / etiology ; Humans ; Male ; Postoperative Complications / diagnosis ; Postoperative Complications / etiology ; Treatment Outcome Contributed Indexing: Keywords: DPP-4 inhibitors; Dumping syndrome; GLP-1 Substance Nomenclature: 0 (Dipeptidyl-Peptidase IV Inhibitors) ; TS63EW8X6F (Sitagliptin Phosphate) Entry Date(s): Date Created: 20171207 Date Completed: 20180924 Latest Revision: 20180924 Update Code: 20231215

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