Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea.
In: Journal of diabetes research, Jg. 2017 (2017), S. 5751687
Online
academicJournal
Zugriff:
Objectives: Patients with diabetic peripheral neuropathy (DPN) is the most common complication. However, patients are usually suffering from not only diverse sensory deficit but also neuropathy-related discomforts. The aim of this study is to identify distinct groups of patients with DPN with respect to its clinical impacts on symptom patterns and comorbidities.
Methods: A hierarchical cluster analysis and factor analysis were performed to identify relevant subgroups of patients with DPN ( n = 1338) and symptom patterns.
Results: Patients with DPN were divided into three clusters: asymptomatic (cluster 1, n = 448, 33.5%), moderate symptoms with disturbed sleep (cluster 2, n = 562, 42.0%), and severe symptoms with decreased quality of life (cluster 3, n = 328, 24.5%). Patients in cluster 3, compared with clusters 1 and 2, were characterized by higher levels of HbA1c and more severe pain and physical impairments. Patients in cluster 2 had moderate pain levels but disturbed sleep patterns comparable to those in cluster 3. The frequency of symptoms on each item of MNSI by "painful" symptom pattern showed a similar distribution pattern with increasing intensities along the three clusters.
Conclusions: Cluster and factor analysis endorsed the use of comprehensive and symptomatic subgrouping to individualize the evaluation of patients with DPN.
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Clinical Phenotype of Diabetic Peripheral Neuropathy and Relation to Symptom Patterns: Cluster and Factor Analysis in Patients with Type 2 Diabetes in Korea.
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Autor/in / Beteiligte Person: | Won, JC ; Im, YJ ; Lee, JH ; Kim, CH ; Kwon, HS ; Cha, BY ; Park, TS |
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Zeitschrift: | Journal of diabetes research, Jg. 2017 (2017), S. 5751687 |
Veröffentlichung: | <2019>-: London, United Kingdom : Hindawi Limited ; <i>Original Publication</i>: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-, 2017 |
Medientyp: | academicJournal |
ISSN: | 2314-6753 (electronic) |
DOI: | 10.1155/2017/5751687 |
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