Einzeltreffer — DigiBib

Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity.

Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained.

Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = - 0.489, p < 0.001) are the independent predictors of XO activity (R 2 -adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction.

Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population.

Level of Evidence: Level V: cross-sectional descriptive study.

Titel:	Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.
Autor/in / Beteiligte Person:	Klisic, A ; Kocic, G ; Kavaric, N ; Jovanovic, M ; Stanisic, V ; Ninic, A
Link:	Full Text Finder (Volltext)
Zeitschrift:	Eating and weight disorders : EWD, Jg. 25 (2020-02-01), Heft 1, S. 9-15
Veröffentlichung:	2013- : Heidelberg : Springer ; <i>Original Publication</i>: Milano, Italy : Editrice Kurtis, c1996-, 2020
Medientyp:	academicJournal
ISSN:	1590-1262 (electronic)
DOI:	10.1007/s40519-018-0490-5
Schlagwort:	Adult Aged C-Reactive Protein metabolism Cross-Sectional Studies Female Humans Inflammation physiopathology Male Middle Aged Obesity physiopathology Overweight physiopathology Uric Acid blood Body Mass Index Obesity enzymology Overweight enzymology Xanthine Oxidase metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Eat Weight Disord] 2020 Feb; Vol. 25 (1), pp. 9-15. <i>Date of Electronic Publication: </i>2018 Feb 22. MeSH Terms: Body Mass Index* ; Obesity / enzymology ; Overweight / enzymology ; Xanthine Oxidase / *metabolism ; Adult ; Aged ; C-Reactive Protein / metabolism ; Cross-Sectional Studies ; Female ; Humans ; Inflammation / physiopathology ; Male ; Middle Aged ; Obesity / physiopathology ; Overweight / physiopathology ; Uric Acid / blood References: Diabetologia. 2004 Aug;47(8):1403-10. (PMID: 15309290) ; Mediators Inflamm. 2016;2016:8603164. (PMID: 28070145) ; Int J Mol Sci. 2013 May 21;14(5):10497-538. (PMID: 23698776) ; Prog Lipid Res. 2016 Jan;61:149-62. (PMID: 26703188) ; Lab Med. 2014 Winter;45(1):12-6. (PMID: 24719979) ; Child Obes. 2016 Aug;12(4):286-91. (PMID: 26978590) ; Eat Weight Disord. 2018 Feb;23(1):133-141. (PMID: 27663696) ; Arthritis Care Res (Hoboken). 2016 Jul;68(7):1036-42. (PMID: 26844534) ; Exp Clin Endocrinol Diabetes. 2017 Jul;125(7):470-477. (PMID: 28445896) ; Arch Med Sci. 2015 Jun 19;11(3):463-82. (PMID: 26170839) ; Ren Fail. 2014 May;36(4):613-8. (PMID: 24502620) ; J Diabetes Res. 2016;2016:4370490. (PMID: 27965983) ; Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):291-8. (PMID: 22095983) ; Free Radic Res. 2007 Nov;41(11):1195-200. (PMID: 17906999) ; Eur J Clin Invest. 2010 Feb;40(2):89-94. (PMID: 20015244) ; Gynecol Endocrinol. 2012 Oct;28(10):787-91. (PMID: 22468900) ; Exp Clin Endocrinol Diabetes. 2017 Nov;125(10):684-689. (PMID: 28750431) ; Br J Clin Pharmacol. 2011 Jul;72(1):109-15. (PMID: 21382071) ; J Transl Med. 2015 Mar 06;13:82. (PMID: 25889404) ; Child Obes. 2014 Apr;10(2):175-80. (PMID: 24568669) ; Exp Clin Endocrinol Diabetes. 2016 Oct;124(9):568-571. (PMID: 27657994) ; Oxid Med Cell Longev. 2014;2014:587083. (PMID: 24967004) ; Exp Clin Endocrinol Diabetes. 2018 Jun;126(6):371-378. (PMID: 28895641) ; Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):44-51. (PMID: 24158515) ; Nutr Metab Cardiovasc Dis. 2010 Dec;20(10):734-9. (PMID: 19765958) ; J Biol Chem. 2013 Sep 20;288(38):27138-49. (PMID: 23913681) ; Biogerontology. 2011 Dec;12(6):551-64. (PMID: 21826556) ; Obesity (Silver Spring). 2012 Dec;20(12):2361-6. (PMID: 22592332) ; Cell Metab. 2007 Feb;5(2):115-28. (PMID: 17276354) Contributed Indexing: Keywords: Inflammation; Obesity; Oxidative stress; Xanthine oxidase Substance Nomenclature: 268B43MJ25 (Uric Acid) ; 9007-41-4 (C-Reactive Protein) ; EC 1.17.3.2 (Xanthine Oxidase) Entry Date(s): Date Created: 20180223 Date Completed: 20201117 Latest Revision: 20201117 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.