Paradoxical skin lesions induced by anti-TNF-α agents in SAPHO syndrome.
In: Clinical rheumatology, Jg. 38 (2019), Heft 1, S. 53-61
Online
academicJournal
Zugriff:
The objectives of the study were to characterize the clinical picture of paradoxical skin lesions in SAPHO patients treated with anti-TNF-α agents and to explore its pathogenesis. Patients treated with anti-TNF-α therapy were identified from a cohort of 164 SAPHO patients. The clinical data and skin biopsies were collected. The usage, efficacy, and side effects of anti-TNF-α therapy were recorded. Forty-one (25.0%) patients received anti-TNF-α therapy, of which seven (17.1%) developed paradoxical skin lesions after 1 to 14 infusions. Patients with such lesions were older at onset of skin lesions than those without (p = 0.034). Expression of TNF-α in palmoplantar pustulosis increased after anti-TNF-α therapy in the two examined patients with exacerbated skin lesions. Anti-TNF-α therapy induces paradoxical skin lesions in 17.1% SAPHO patients. Late onset of skin manifestations is associated with an increased risk of such lesions. The paradoxical elevation of TNF-α expression in lesions may contribute to this phenomenon.
| Titel: |
Paradoxical skin lesions induced by anti-TNF-α agents in SAPHO syndrome.
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| Autor/in / Beteiligte Person: | Li, C ; Wu, X ; Cao, Y ; Zeng, Y ; Zhang, W ; Zhang, S ; Liu, Y ; Jin, H ; Li, L |
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| Zeitschrift: | Clinical rheumatology, Jg. 38 (2019), Heft 1, S. 53-61 |
| Veröffentlichung: | <2008->: Heidelberg : Springer ; <i>Original Publication</i>: Brussels : Acta Medica Belgica, [1982-, 2019 |
| Medientyp: | academicJournal |
| ISSN: | 1434-9949 (electronic) |
| DOI: | 10.1007/s10067-018-4083-5 |
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