Einzeltreffer — DigiBib

MicroProteins are small proteins that contain a single protein domain and are related to larger, often multi-domain proteins. At the molecular level, microProteins act by interfering with the formation of higher order protein complexes. In the past years, several microProteins have been identified in plants and animals that strongly influence biological processes. Due to their ability to act as dominant regulators in a targeted manner, microProteins have a high potential for biotechnological use. In this review, we present different ways in which microProteins are generated and we elaborate on techniques used to identify and characterize them. Finally, we give an outlook on possible applications in biotechnology.

Titel:	Approaches to identify and characterize microProteins and their potential uses in biotechnology.
Autor/in / Beteiligte Person:	Bhati, KK ; Blaakmeer, A ; Paredes, EB ; Dolde, U ; Eguen, T ; Hong, SY ; Rodrigues, V ; Straub, D ; Sun, B ; Wenkel, S
Link:	Full Text Finder (Volltext)
Zeitschrift:	Cellular and molecular life sciences : CMLS, Jg. 75 (2018-07-01), Heft 14, S. 2529-2536
Veröffentlichung:	Basel : Springer ; <i>Original Publication</i>: Basel ; Boston : Birkhauser, c1997-, 2018
Medientyp:	academicJournal
ISSN:	1420-9071 (electronic)
DOI:	10.1007/s00018-018-2818-8
Schlagwort:	Animals Humans Open Reading Frames genetics Proteins metabolism Proteolysis RNA Isoforms genetics Alternative Splicing Biotechnology methods Computational Biology methods Proteins genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review Language: English [Cell Mol Life Sci] 2018 Jul; Vol. 75 (14), pp. 2529-2536. <i>Date of Electronic Publication: </i>2018 Apr 18. MeSH Terms: Alternative Splicing* ; Biotechnology / methods ; Computational Biology / methods ; Proteins / *genetics ; Animals ; Humans ; Open Reading Frames / genetics ; Proteins / metabolism ; Proteolysis ; RNA Isoforms / genetics References: Genome Biol Evol. 2017 Mar 1;9(3):777-789. (PMID: 28338802) ; Nat Chem Biol. 2017 Feb;13(2):174-180. (PMID: 27918561) ; Plant J. 2012 Oct;72(1):162-72. (PMID: 22672153) ; Philos Trans R Soc Lond B Biol Sci. 1970 Feb 12;257(813):249-64. (PMID: 4399049) ; Nat Rev Genet. 2010 Sep;11(9):636-46. (PMID: 20717154) ; Plant Cell. 2018 Jan;30(1):83-100. (PMID: 29298836) ; Plant Cell. 2014 Jul;26(7):2746-60. (PMID: 25035402) ; Methods Mol Biol. 2017;1610:231-249. (PMID: 28439867) ; Trends Biochem Sci. 2016 Aug;41(8):665-678. (PMID: 27261332) ; Nucleic Acids Res. 2016 Jan 4;44(D1):D324-9. (PMID: 26527729) ; J Biol Chem. 2011 Jan 14;286(2):1659-68. (PMID: 21059647) ; Biomol Concepts. 2012 Feb;3(1):71-8. (PMID: 25436525) ; Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2191-2199. (PMID: 28711385) ; PLoS Genet. 2016 Mar 25;12(3):e1005959. (PMID: 27015278) ; Plant Cell. 2008 Apr;20(4):920-33. (PMID: 18408069) ; Nat Methods. 2013 Feb;10(2):133-9. (PMID: 23241633) ; EMBO Rep. 2011 Jan;12(1):35-42. (PMID: 21151039) ; Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2395-400. (PMID: 23341627) ; Nat Rev Genet. 2014 Mar;15(3):205-13. (PMID: 24468696) ; Cell. 2008 Aug 22;134(4):679-91. (PMID: 18724940) ; Plant Cell. 2007 Nov;19(11):3379-90. (PMID: 18055602) ; Nucleic Acids Res. 2017 May 19;45(9):5061-5073. (PMID: 28402429) ; Proteomics. 2010 Mar;10(6):1284-96. (PMID: 20058249) ; Trends Plant Sci. 2015 Aug;20(8):477-82. (PMID: 26115780) ; Plant Physiol. 2018 Apr;176(4):3136-3145. (PMID: 29382693) ; Plant J. 2006 Feb;45(3):399-422. (PMID: 16412086) ; New Phytol. 2018 May;218(3):936-943. (PMID: 28493421) ; Mol Phylogenet Evol. 2014 Dec;81:159-73. (PMID: 25263420) ; Plant Biotechnol J. 2010 Aug;8(6):655-77. (PMID: 20331529) ; Science. 2011 Sep 30;333(6051):1843-6. (PMID: 21960622) ; Nature. 2017 Sep 20;549(7673):548-552. (PMID: 28959974) ; Cell Res. 2012 Feb;22(2):360-71. (PMID: 21769134) ; Mol Cell. 2004 Apr 23;14(2):259-67. (PMID: 15099524) ; Science. 2014 Nov 28;346(6213):1258096. (PMID: 25430774) ; Cell. 1990 Apr 6;61(1):49-59. (PMID: 2156629) ; Methods Mol Biol. 2017;1543:111-126. (PMID: 28349423) ; Plant Cell Physiol. 2017 Jan 1;58(1):46-56. (PMID: 27856772) ; Bioorg Med Chem Lett. 2017 Dec 1;27(23):5089-5099. (PMID: 29110985) ; J Integr Plant Biol. 2008 Aug;50(8):1031-45. (PMID: 18713354) ; Expert Rev Proteomics. 2017 May;14(5):409-418. (PMID: 28395554) ; Cell Death Differ. 2015 Dec;22(12):2087-97. (PMID: 25976304) ; Nat Rev Mol Cell Biol. 2002 Jul;3(7):509-19. (PMID: 12094217) Grant Information: 336295 International European Research Council Contributed Indexing: Keywords: Complex; Inhibition; MiPFinder; MicroProtein; Protein–protein interaction; Small proteins; Targets Substance Nomenclature: 0 (Proteins) ; 0 (RNA Isoforms) Entry Date(s): Date Created: 20180420 Date Completed: 20181029 Latest Revision: 20240522 Update Code: 20240522 PubMed Central ID: PMC6003976

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Approaches to identify and characterize microProteins and their potential uses in biotechnology.