Einzeltreffer — DigiBib

Objective: Systemic lupus erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex and are further complicated by unique concerns that are dependent upon sex-defined roles. We aimed to describe sex differences in disease-specific quality of life (QoL) assessment scores using the Lupus Patient-Reported Outcome (LupusPRO) tool in a large international study.

Methods: Cross-sectional data from 1,803 patients with SLE on demographics, self-identified sex status, LupusPRO, and disease activity were analyzed. The LupusPRO tool has 2 constructs: health-related QoL (HRQoL) and non-HRQoL. Disease activity and damage were evaluated using the Safety of Estrogens in Lupus Erythematosus National Assessment version of the Systemic Lupus Erythematosus Disease Activity Index and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, respectively. Nonparametric tests were used to compare QoL and disease activity by sex.

Results: A total of 122 men and 1,681 women with SLE participated. The mean age was similar by sex, but the damage scores were greater among men. Men fared worse on the non-HRQoL social support domain than women (P = 0.02). When comparing disease and QoL among men and women ages ≤45 years, men were found to have greater damage and worse social support than women. However, women fared significantly worse on lupus symptoms, cognition, and procreation domains with trends for worse functioning on physical health and pain-vitality domains.

Conclusion: In the largest study of a diverse group of SLE patients, utilizing a disease-specific QoL tool, sex differences in QoL were observed on both HRQoL and non-HRQoL constructs. Although men performed worse in the social support domain, women (especially those in the reproductive age group) fared worse in other domains. These observations may assist physicians in appropriately addressing QoL issues in a sex-focused manner.

Titel:	Sex Differences in Quality of Life in Patients With Systemic Lupus Erythematosus.
Autor/in / Beteiligte Person:	Jolly, M ; Sequeira, W ; Block, JA ; Toloza, S ; Bertoli, A ; Blazevic, I ; Vila, LM ; Moldovan, I ; Torralba, KD ; Mazzoni, D ; Cicognani, E ; Hasni, S ; Goker, B ; Haznedaroglu, S ; Bourre-Tessier, J ; Navarra, SV ; Mok, CC ; Weisman, M ; Clarke, AE ; Wallace, D ; Alarcón, G
Link:	Full Text Finder (Volltext)
Zeitschrift:	Arthritis care & research, Jg. 71 (2019-12-01), Heft 12, S. 1647-1652
Veröffentlichung:	Hoboken, NJ : John Wiley & Sons, 2019
Medientyp:	academicJournal
ISSN:	2151-4658 (electronic)
DOI:	10.1002/acr.23588
Schlagwort:	Adult Asia epidemiology Canada epidemiology Cross-Sectional Studies Europe epidemiology Female Humans Lupus Erythematosus, Systemic psychology Male Middle Aged Morbidity trends Patient Reported Outcome Measures Severity of Illness Index Sex Distribution Sex Factors United States epidemiology Health Status Lupus Erythematosus, Systemic epidemiology Psychometrics methods Quality of Life
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Language: English [Arthritis Care Res (Hoboken)] 2019 Dec; Vol. 71 (12), pp. 1647-1652. <i>Date of Electronic Publication: </i>2018 Dec 20. MeSH Terms: Health Status* ; Quality of Life* ; Lupus Erythematosus, Systemic / epidemiology ; Psychometrics / methods ; Adult ; Asia / epidemiology ; Canada / epidemiology ; Cross-Sectional Studies ; Europe / epidemiology ; Female ; Humans ; Lupus Erythematosus, Systemic / psychology ; Male ; Middle Aged ; Morbidity / trends ; Patient Reported Outcome Measures ; Severity of Illness Index ; Sex Distribution ; Sex Factors ; United States / epidemiology References: Cell Mol Biol (Noisy-le-grand). 2003 Dec;49(8):1339-44. (PMID: 14984007) ; Scand J Rheumatol. 2009 Mar-Apr;38(2):121-7. (PMID: 18991189) ; Lupus. 2004;13(12):924-6. (PMID: 15645747) ; Qual Life Res. 2009 May;18(4):435-46. (PMID: 19247807) ; Anxiety Stress Coping. 2016 Sep;29(5):542-51. (PMID: 26691287) ; Adv Exp Med Biol. 1999;455:173-9. (PMID: 10599340) ; Arthritis Rheum. 1997 Sep;40(9):1725. (PMID: 9324032) ; J Rheumatol. 2013 Aug;40(8):1327-33. (PMID: 23772082) ; Soc Work Health Care. 2014;53(5):435-45. (PMID: 24835088) ; J Rheumatol. 1997 Aug;24(8):1608-14. (PMID: 9263159) ; Int J Public Health. 2009 Jun;54 Suppl 1:106-10. (PMID: 19365604) ; Arthritis Care Res (Hoboken). 2015 Feb;67(2):297-304. (PMID: 25156199) ; Lupus. 2013 Mar;22(3):262-7. (PMID: 23340995) ; Lupus. 1999;8(3):188-96. (PMID: 10342711) ; J Rheumatol. 2005 Sep;32(9):1706-8. (PMID: 16142864) ; Arthritis Rheum. 2007 Feb;56(2):622-30. (PMID: 17265497) ; Gend Med. 2008 Sep;5(3):270-8. (PMID: 18727993) ; Lupus. 2013 Apr;22(5):431-6. (PMID: 23554032) ; N Engl J Med. 2005 Dec 15;353(24):2550-8. (PMID: 16354891) ; Lupus. 2014 Dec;23(14):1452-9. (PMID: 25081500) ; Nutr Metab Cardiovasc Dis. 2009 Jan;19(1):45-53. (PMID: 18450436) ; Semin Arthritis Rheum. 2012 Aug;42(1):56-65. (PMID: 22480408) ; Clin J Am Soc Nephrol. 2009 Aug;4(8):1293-301. (PMID: 19643926) ; J Pers Soc Psychol. 1984 Apr;46(4):877-91. (PMID: 6737198) ; Lupus. 2016 Oct;25(12):1315-27. (PMID: 26989166) ; Clin Exp Rheumatol. 2004 Nov-Dec;22(6):713-21. (PMID: 15638045) ; Lupus. 2000;9(9):708-12. (PMID: 11199927) ; Br J Rheumatol. 1996 Mar;35(3):248-54. (PMID: 8620300) ; Clin Rheumatol. 2014 Aug;33(8):1079-84. (PMID: 23934384) Grant Information: Z99 AR999999 United States ImNIH Intramural NIH HHS; International NIH Entry Date(s): Date Created: 20180426 Date Completed: 20200413 Latest Revision: 20210109 Update Code: 20240513 PubMed Central ID: PMC6202275

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Sex Differences in Quality of Life in Patients With Systemic Lupus Erythematosus.