High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes.
In: Journal of endocrinological investigation, Jg. 42 (2019-03-01), Heft 3, S. 295-301
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Zugriff:
Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM.
Methods: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3.6 ± 0.9 years). Previous fragility fractures were recorded. The FRAX score (without BMD) was calculated and biochemical parameters (plasma glucose, HbA1c, lipid profile and renal function) were assessed. Serum 25OH-vitamin D, calcium, PTH and OPN were evaluated at baseline. The association between OPN and fracture prevalence at baseline was evaluated by a logistic model.
Results: OPN levels were higher in patients with previous fractures (n.25) than in patients without previous fractures at baseline (n.39) (p = 0.006). The odds of having fractures at baseline increased by 6.7 (1.9-31.4, 95% CI, p = 0.007) for each increase of 1 ng/ml in OPN levels, after adjustment for vitamin D and HbA1c levels. Fracture incidence was 4.7%. Higher OPN associated with a decrease in HDL-cholesterol (p = 0.048), after adjustment for age, basal HDL-cholesterol, basal and follow-up HbA1c and follow-up duration. 25OH-vitamin D associated with an increase in FRAX-estimated probability of hip fracture at follow-up (p = 0.029), after adjustment for age, 25OH-vitamin D and time.
Conclusions: In post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile.
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High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes.
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Autor/in / Beteiligte Person: | Filardi, T ; Carnevale, V ; Massoud, R ; Russo, C ; Nieddu, L ; Tavaglione, F ; Turinese, I ; Lenzi, A ; Romagnoli, E ; Morano, S |
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Zeitschrift: | Journal of endocrinological investigation, Jg. 42 (2019-03-01), Heft 3, S. 295-301 |
Veröffentlichung: | 2014- : Berlin : Springer ; <i>Original Publication</i>: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis., 2019 |
Medientyp: | academicJournal |
ISSN: | 1720-8386 (electronic) |
DOI: | 10.1007/s40618-018-0914-0 |
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