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We examined the relationship among white matter (WM) tract integrity, WM hyperintensities (WMH), lobar gray matter (GM) volumes, and cognition in the cross-sectional Framingham Offspring Study. Six hundred eighty participants (71.7 ± 7.7 years) completed cognitive testing and magnetic resonance imaging. Diffusion tensor imaging probabilistic tractography was used to reconstruct major WM tracts. We computed tract-specific mean fractional anisotropy (FA) and tract-specific WMH ratio. Linear regressions identified relations between tracts and lobar GM volumes. Partial least squares regression examined associations between integrity of combined tracts, lobar GM volumes and cognition, including scores of memory and processing speed. Five tracts were particularly vulnerable to WMH, and tract-specific WMH volumes were inversely associated with tract-specific FA (p values < 0.05). Tract-specific FA related to lobar GM volumes. Memory was associated with lobar GM, while processing speed related to both tract integrity and lobar GM volumes. We conclude that subtle microstructural WM tract degeneration relates to specific lobar GM atrophy. The integrity of associated WM tracts and GM lobes differentially impacts memory and processing speed.

Titel:	Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.
Autor/in / Beteiligte Person:	Seiler, S ; Fletcher, E ; Hassan-Ali, K ; Weinstein, M ; Beiser, A ; Himali, JJ ; Satizabal, CL ; Seshadri, S ; DeCarli, C ; Maillard, P
Zeitschrift:	Neurobiology of aging, Jg. 72 (2018-12-01), S. 14-22
Veröffentlichung:	New York : Elsevier ; <i>Original Publication</i>: Fayetteville, N.Y. : Ankho International., 2018
Medientyp:	academicJournal
ISSN:	1558-1497 (electronic)
DOI:	10.1016/j.neurobiolaging.2018.08.005
Schlagwort:	Aged Aged, 80 and over Cerebral Cortex diagnostic imaging Cerebral Cortex physiopathology Cognitive Aging physiology Diffusion Tensor Imaging methods Female Humans Male Middle Aged White Matter diagnostic imaging Aging pathology Aging physiology Cerebral Cortex pathology Cerebral Cortex physiology Cognition physiology Cognitive Dysfunction physiopathology Magnetic Resonance Imaging methods White Matter pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [Neurobiol Aging] 2018 Dec; Vol. 72, pp. 14-22. <i>Date of Electronic Publication: </i>2018 Aug 09. MeSH Terms: Aging / pathology ; Aging / physiology ; Cerebral Cortex / pathology ; Cerebral Cortex / physiology ; Cognition / physiology ; Cognitive Dysfunction / physiopathology ; Magnetic Resonance Imaging / methods ; White Matter / pathology ; Aged ; Aged, 80 and over ; Cerebral Cortex / diagnostic imaging ; Cerebral Cortex / physiopathology ; Cognitive Aging / physiology ; Diffusion Tensor Imaging / methods ; Female ; Humans ; Male ; Middle Aged ; White Matter / diagnostic imaging References: Exp Aging Res. 2004 Oct-Dec;30(4):333-58. (PMID: 15371099) ; Radiology. 2011 Jun;259(3):844-51. (PMID: 21467255) ; Cereb Cortex. 2009 Jan;19(1):72-8. (PMID: 18403396) ; Neuroimage. 2012 Aug 15;62(2):782-90. 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(PMID: 28473633) Grant Information: R01 NS017950 United States NS NINDS NIH HHS; R01 HL107385 United States HL NHLBI NIH HHS; K23 HL118529 United States HL NHLBI NIH HHS; N01 HC025195 United States HC NHLBI NIH HHS; R01 HL076784 United States HL NHLBI NIH HHS; R01 HL060040 United States HL NHLBI NIH HHS; R01 AG008122 United States AG NIA NIH HHS; HHSN268201500001I United States HL NHLBI NIH HHS; N01HC25195 United States HL NHLBI NIH HHS; P30 AG010129 United States AG NIA NIH HHS; R01 HL080124 United States HL NHLBI NIH HHS; R01 AG028321 United States AG NIA NIH HHS; R01 HL070100 United States HL NHLBI NIH HHS; U01 AG049505 United States AG NIA NIH HHS; R01 HL071039 United States HL NHLBI NIH HHS; UH3 NS100605 United States NS NINDS NIH HHS; R01 NS071039 United States NS NINDS NIH HHS; R01 AG054076 United States AG NIA NIH HHS; K24 HL004334 United States HL NHLBI NIH HHS; R01 HL077447 United States HL NHLBI NIH HHS; R01 AG033040 United States AG NIA NIH HHS; U01 AG052409 United States AG NIA NIH HHS Contributed Indexing: Keywords: Cognitive aging; Diffusion tensor imaging; Magnetic resonance imaging; Tractography; WMH; White matter hyperintensities Entry Date(s): Date Created: 20180903 Date Completed: 20190916 Latest Revision: 20240620 Update Code: 20240620 PubMed Central ID: PMC6242702

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Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.