Einzeltreffer — DigiBib

Introduction: Type 2 diabetes mellitus and obesity may increase risks for cognitive decline as individuals age. It is unknown whether this results in different prevalences of cognitive impairment for women and men.

Methods: The Action for Health in Diabetes, a randomized controlled clinical trial of a 10-year intensive lifestyle intervention, adjudicated cases of cross-sectional cognitive impairment (mild cognitive impairment or dementia) 10-13 years after enrollment in 3802 individuals (61% women).

Results: The cross-sectional prevalences of cognitive impairment were 8.3% (women) and 14.8% (men): adjusted odds ratio 0.55, 95% confidence interval [0.43, 0.71], P < .001. Demographic, clinical, and lifestyle risk factors varied between women and men but did not account for this difference, which was limited to individuals without apolipoprotein E (APOE)-ε4 alleles (interaction P = .034).

Conclusions: Among overweight and obese adults with type 2 diabetes mellitus, traditional risk factors did not account for the lower prevalence of cognitive impairment observed in women compared with men.

Titel:	Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes.
Autor/in / Beteiligte Person:	Espeland, MA ; Carmichael, O ; Yasar, S ; Hugenschmidt, C ; Hazzard, W ; Hayden, KM ; Rapp, SR ; Neiberg, R ; Johnson, KC ; Hoscheidt, S ; Mielke, MM
Link:	Full Text Finder (Volltext)
Zeitschrift:	Alzheimer's & dementia : the journal of the Alzheimer's Association, Jg. 14 (2018-09-01), Heft 9, S. 1184-1192
Veröffentlichung:	2020- : Hoboken, NJ : John Wiley & Sons, Ltd. ; <i>Original Publication</i>: Orlando, FL : Elsevier, Inc., 2018
Medientyp:	academicJournal
ISSN:	1552-5279 (electronic)
DOI:	10.1016/j.jalz.2018.05.015
Schlagwort:	Aged Behavior Therapy Cross-Sectional Studies Female Humans Life Style Male Middle Aged Prevalence Cognitive Dysfunction epidemiology Diabetes Mellitus, Type 2 complications Obesity complications Overweight complications Sex Characteristics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: Action for Health in Diabetes (Look AHEAD) Research Group Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Language: English [Alzheimers Dement] 2018 Sep; Vol. 14 (9), pp. 1184-1192. <i>Date of Electronic Publication: </i>2018 Jul 05. MeSH Terms: Sex Characteristics* ; Cognitive Dysfunction / epidemiology ; Diabetes Mellitus, Type 2 / complications ; Obesity / complications ; Overweight / complications ; Aged ; Behavior Therapy ; Cross-Sectional Studies ; Female ; Humans ; Life Style ; Male ; Middle Aged ; Prevalence References: Control Clin Trials. 2003 Oct;24(5):610-28. (PMID: 14500058) ; J Gerontol. 1982 May;37(3):323-9. (PMID: 7069156) ; Neurology. 2016 Aug 16;87(7):699-708. (PMID: 27421538) ; Neurology. 2017 May 23;88(21):2026-2035. (PMID: 28446656) ; J Alzheimers Dis. 2017;59(2):445-466. (PMID: 28655134) ; Biol Sex Differ. 2013 Mar 28;4(1):6. (PMID: 23537114) ; Epidemiology. 2012 Jan;23(1):119-28. (PMID: 21989136) ; Obesity (Silver Spring). 2012 May;20(5):1088-95. (PMID: 22240723) ; Neurobiol Aging. 2016 Jun;42:69-79. (PMID: 27143423) ; N Engl J Med. 2013 Jul 11;369(2):145-54. (PMID: 23796131) ; J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):103-9. (PMID: 19168781) ; Diabetes Care. 2016 Feb;39(2):300-7. (PMID: 26681727) ; JAMA. 2004 Jun 23;291(24):2959-68. (PMID: 15213207) ; Diabetes Care. 2014 Sep;37(9):2515-21. (PMID: 24947788) ; Geriatr Gerontol Int. 2017 Nov;17(11):2136-2142. (PMID: 28509397) ; Neurology. 2015 Sep 29;85(13):1131-8. (PMID: 26163429) ; Neurobiol Aging. 2005 Dec;26 Suppl 1:11-6. (PMID: 16223549) ; Obesity (Silver Spring). 2006 May;14(5):737-52. (PMID: 16855180) ; JAMA Intern Med. 2013 Aug 12;173(15):1429-36. (PMID: 23797469) ; Neuroepidemiology. 2012;38(4):237-44. (PMID: 22572745) ; Lancet. 1998 Jun 20;351(9119):1840-3. (PMID: 9652667) ; Clin Epidemiol. 2014 Jan 08;6:37-48. (PMID: 24470773) ; Clin Endocrinol (Oxf). 2005 Jul;63(1):50-5. (PMID: 15963061) ; J Alzheimers Dis. 2014;42(4):1269-77. (PMID: 25024326) ; N Engl J Med. 1986 Mar 6;314(10):605-13. (PMID: 3945246) ; Neurology. 2017 Jul 18;89(3):249-255. (PMID: 28615420) ; Mol Neurobiol. 2017 Oct;54(8):6471-6489. (PMID: 27730513) ; JAMA Neurol. 2015 May;72(5):511-9. (PMID: 25775353) ; J Gerontol A Biol Sci Med Sci. 2014 Sep;69(9):1101-8. (PMID: 24619151) ; Clin Interv Aging. 2014 Aug 27;9:1425-36. (PMID: 25210447) ; J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):979-84. (PMID: 18450788) ; J Am Geriatr Soc. 2017 May;65(5):966-972. (PMID: 28067945) ; J Geriatr Psychiatry Neurol. 2017 Mar;30(2):67-76. (PMID: 28077009) ; Diabetes Care. 2015 Dec;38(12):2316-24. (PMID: 26486190) ; Alzheimers Dement. 2016 Nov;12(11):1186-1196. (PMID: 27692800) ; Gend Med. 2007 Jun;4(2):120-9. (PMID: 17707846) ; Neurology. 2017 Oct 31;89(18):1886-1893. (PMID: 28978656) ; Alzheimer Dis Assoc Disord. 2006 Apr-Jun;20(2):93-100. (PMID: 16772744) ; Front Neuroendocrinol. 2014 Aug;35(3):385-403. (PMID: 24434111) ; Psychosom Med. 2007 Jun;69(5):425-34. (PMID: 17556639) ; J Geriatr Psychiatry Neurol. 2016 May;29(3):120-5. (PMID: 26862150) ; J Clin Endocrinol Metab. 2008 May;93(5):1834-40. (PMID: 18319314) ; JAMA. 2003 May 28;289(20):2663-72. (PMID: 12771113) ; PLoS Med. 2015 Jun 02;12(6):e1001833; discussion e1001833. (PMID: 26035291) ; Arch Neurol. 2011 Jan;68(1):51-7. (PMID: 20837822) Grant Information: K01 AG043547 United States AG NIA NIH HHS; U01 DK057151 United States DK NIDDK NIH HHS; P30 DK046204 United States DK NIDDK NIH HHS; U01 DK057154 United States DK NIDDK NIH HHS; U01 DK056992 United States DK NIDDK NIH HHS; U01 DK057171 United States DK NIDDK NIH HHS; U01 DK057182 United States DK NIDDK NIH HHS; U01 DK057002 United States DK NIDDK NIH HHS; U01 DK057177 United States DK NIDDK NIH HHS; U54 AG044170 United States AG NIA NIH HHS; U01 DK057078 United States DK NIDDK NIH HHS; U01 DK057131 United States DK NIDDK NIH HHS; U01 DK057008 United States DK NIDDK NIH HHS; U01 DK057149 United States DK NIDDK NIH HHS; RF1 AG055151 United States AG NIA NIH HHS; M01 RR001346 United States RR NCRR NIH HHS; U01 DK057135 United States DK NIDDK NIH HHS; UL1 RR024153 United States RR NCRR NIH HHS; M01 RR000056 United States RR NCRR NIH HHS; U01 DK057219 United States DK NIDDK NIH HHS; P30 AG049638 United States AG NIA NIH HHS; U01 DK057136 United States DK NIDDK NIH HHS; U01 DK056990 United States DK NIDDK NIH HHS; U01 DK057178 United States DK NIDDK NIH HHS Contributed Indexing: Keywords: Cognitive impairment; Obesity; Risk factors; Sex differences; Type 2 diabetes mellitus Molecular Sequence: ClinicalTrials.gov NCT00017953 Entry Date(s): Date Created: 20180912 Date Completed: 20191111 Latest Revision: 20240608 Update Code: 20240608 PubMed Central ID: PMC6338071

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes.