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The amyloid precursor protein (APP) is a member of a conserved gene family that includes the amyloid precursor-like proteins 1 (APLP1) and 2 (APLP2). APP and APLP2 share a high degree of similarity, and have overlapping patterns of spatial and temporal expression in the central and peripheral tissues, in particular at the neuromuscular junction. APP-family knockout (KO) studies have helped elucidate aspects of function and functional redundancy amongst the APP-family members. In the present study, we investigated motor performance of APLP2-KO mice and the effect sex differences and age-related changes have on motor performance. APLP2-KO and WT (on C57Bl6 background) littermates control mice from 8 (young adulthood) to 48 weeks (middle age) were investigated. Analysis of motor neuron and muscle morphology showed APLP2-KO females but not males, had less age-related motor function impairments. We observed age and sex differences in both motor neuron number and muscle fiber size distribution for APLP2-KO mice compared to WT (C57Bl6). These alterations in the motor neuron number and muscle fiber distribution pattern may explain why female APLP2-KO mice have far better motor function behaviour during ageing.

Titel:	Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex.
Autor/in / Beteiligte Person:	Truong, PH ; Ciccotosto, GD ; Cappai, R
Link:	Full Text Finder (Volltext)
Zeitschrift:	Neurochemical research, Jg. 44 (2019-06-01), Heft 6, S. 1356-1366
Veröffentlichung:	1999- : New York, NY : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York, Plenum Press, 2019
Medientyp:	academicJournal
ISSN:	1573-6903 (electronic)
DOI:	10.1007/s11064-018-2669-6
Schlagwort:	Age Factors Aging pathology Amyloid beta-Protein Precursor genetics Animals Female Male Mice, Inbred C57BL Mice, Knockout Motor Neurons pathology Muscle, Skeletal pathology Sex Factors Spinal Cord pathology Aging physiology Amyloid beta-Protein Precursor deficiency Motor Activity physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Neurochem Res] 2019 Jun; Vol. 44 (6), pp. 1356-1366. <i>Date of Electronic Publication: </i>2018 Oct 25. MeSH Terms: Aging / physiology ; Amyloid beta-Protein Precursor / deficiency ; Motor Activity / *physiology ; Age Factors ; Aging / pathology ; Amyloid beta-Protein Precursor / genetics ; Animals ; Female ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Neurons / pathology ; Muscle, Skeletal / pathology ; Sex Factors ; Spinal Cord / pathology References: Mol Cell Neurosci. 2000 Apr;15(4):355-67. (PMID: 10845772) ; J Neurosci. 2000 Nov 1;20(21):7951-63. (PMID: 11050115) ; Muscle Nerve. 2001 Jul;24(7):848-66. (PMID: 11410913) ; Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62. (PMID: 1279693) ; J Neurotrauma. 2003 Jun;20(6):533-41. (PMID: 12906738) ; Acta Physiol Scand. 1960 Sep 30;50:32-40. (PMID: 13725574) ; Brain Res. 2004 Feb 13;998(1):113-21. (PMID: 14725974) ; EMBO J. 2004 Oct 13;23(20):4106-15. (PMID: 15385965) ; J Neurosci. 2005 Feb 2;25(5):1219-25. (PMID: 15689559) ; Neurosci Lett. 2005 Aug 12-19;384(1-2):66-71. (PMID: 15919150) ; Neuroscience. 2006;137(2):413-23. (PMID: 16330151) ; Genes Brain Behav. 2007 Mar;6(2):192-200. (PMID: 16827921) ; Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14140-5. (PMID: 17709753) ; Behav Brain Res. 2008 Jan 10;186(1):126-32. (PMID: 17884188) ; J Pathol. 2008 Jun;215(2):155-63. (PMID: 18393365) ; J Plast Reconstr Aesthet Surg. 2009 Jun;62(6):806-13. (PMID: 18417437) ; Neurobiol Dis. 2008 Aug;31(2):250-60. (PMID: 18585048) ; Nat Rev Genet. 2008 Dec;9(12):911-22. (PMID: 19002143) ; Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13588-93. (PMID: 19651609) ; Neurobiol Aging. 2011 Oct;32(10):1868-80. (PMID: 20005598) ; Exp Gerontol. 2010 May;45(5):389-93. (PMID: 20226849) ; Nature. 2010 Mar 25;464(7288):529-35. (PMID: 20336135) ; J Neurosurg Anesthesiol. 2010 Jul;22(3):214-9. (PMID: 20479674) ; Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14863-8. (PMID: 20679195) ; EMBO J. 2011 Jun 1;30(11):2266-80. (PMID: 21522131) ; J Integr Neurosci. 2011 Sep;10(3):243-76. (PMID: 21960303) ; Exp Brain Res. 2012 Apr;217(3-4):435-40. (PMID: 22006270) ; Physiol Rev. 2011 Oct;91(4):1447-531. (PMID: 22013216) ; J Neurosci. 2011 Oct 19;31(42):14910-9. (PMID: 22016524) ; PLoS One. 2011;6(12):e28090. (PMID: 22164231) ; Mol Cell Neurosci. 2012 Apr;49(4):448-55. (PMID: 22353605) ; J Neurochem. 2012 Jul;122(1):208-20. (PMID: 22519988) ; Ther Adv Chronic Dis. 2011 May;2(3):175-95. (PMID: 23251749) ; Exp Neurol. 2013 Sep;247:410-8. (PMID: 23333563) ; PLoS One. 2013 Apr 09;8(4):e61198. (PMID: 23585881) ; FEBS Lett. 2013 Jun 27;587(13):2046-54. (PMID: 23684647) ; J Neurochem. 2013 Oct;127(1):48-56. (PMID: 23815291) ; Sci Rep. 2013;3:2116. (PMID: 23817037) ; J Neurochem. 2014 Jun;129(5):756-69. (PMID: 24517464) ; Muscles Ligaments Tendons J. 2014 Feb 24;3(4):346-50. (PMID: 24596700) ; Acta Neuropathol Commun. 2014 Mar 31;2:36. (PMID: 24684730) ; Nat Commun. 2014 Apr 01;5:3569. (PMID: 24686533) ; Mol Cell Neurosci. 2014 Jul;61:201-10. (PMID: 24998676) ; J Neurotrauma. 2016 May 1;33(9):880-94. (PMID: 25951234) ; J Physiol. 2016 Apr 15;594(8):1965-78. (PMID: 26437581) ; Mol Brain. 2016 Jan 28;9:11. (PMID: 26822304) ; Toxics. 2015 Jan 1;3(1):1-17. (PMID: 27081652) ; Muscle Nerve. 2017 Jun;55(6):894-901. (PMID: 27464347) ; J Neurosci. 2016 Aug 10;36(32):8356-71. (PMID: 27511009) ; Skelet Muscle. 2016 Dec 13;6(1):45. (PMID: 27964759) ; Front Mol Neurosci. 2017 Jan 20;9:161. (PMID: 28163673) ; Nat Rev Neurosci. 2017 May;18(5):281-298. (PMID: 28360418) ; Aging Cell. 2018 Apr;17(2):. (PMID: 29397579) ; Neurobiol Aging. 2018 Jul;67:128-136. (PMID: 29656012) ; Sci Rep. 2018 Jul 16;8(1):10742. (PMID: 30013130) ; Brain Res. 1982 Aug;256(4):473-9. (PMID: 7127154) ; Exp Aging Res. 1981 Winter;7(4):427-51. (PMID: 7333338) ; Cell. 1995 May 19;81(4):525-31. (PMID: 7758106) ; Cell. 1994 Dec 2;79(5):755-65. (PMID: 8001115) ; Nat Genet. 1993 Sep;5(1):95-100. (PMID: 8220435) ; J Neurophysiol. 1977 May;40(3):667-80. (PMID: 874534) ; J Neurol Sci. 1977 Nov;34(2):213-9. (PMID: 925710) ; Neurobiol Aging. 1997 Nov-Dec;18(6):661-9. (PMID: 9461064) ; Mech Ageing Dev. 1998 Dec 1;106(1-2):205-16. (PMID: 9883984) Contributed Indexing: Keywords: Ageing; Amyloid precursor protein; Amyloid precursor-like protein; Knockout; Motor neurons; Sex differences Substance Nomenclature: 0 (Amyloid beta-Protein Precursor) ; 0 (Aplp2 protein, mouse) Entry Date(s): Date Created: 20181027 Date Completed: 20190611 Latest Revision: 20200225 Update Code: 20240513

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Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex.