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IL-27 regulates immune responses in inflammation. The underlying mechanism of IL-27 functions has long been attributed to its ability to induce IL-10 production in activated CD4 T cells. In this study, we report that Foxp3 + regulatory T cells (Tregs) are the main target cells of IL-27, mediating its immunoregulatory functions in vivo. Systemically delivered IL-27 efficiently prevents the development of experimental autoimmune encephalomyelitis, an autoimmune inflammation in the CNS. However, it failed to do so upon Treg depletion. IL-27 signaling in Tregs was necessary, as transferring Tregs deficient in IL-27Rα or Lag3, a downstream molecule induced by IL-27, was unable to protect mice from experimental autoimmune encephalomyelitis. IL-27 efficiently induced IL-10 expression in CD4 T cells in vitro; however, we found no evidence supporting IL-27-induced IL-10 induction in CD4 T cells in vivo. Taken together, our results uncover an irreplaceable contribution of Tregs during IL-27-mediated control of inflammation.

Titel:	Cutting Edge: IL-27 Attenuates Autoimmune Neuroinflammation via Regulatory T Cell/Lag3-Dependent but IL-10-Independent Mechanisms In Vivo.
Autor/in / Beteiligte Person:	Kim, D ; Le, HT ; Nguyen, QT ; Kim, S ; Lee, J ; Min, B
Zeitschrift:	Journal of immunology (Baltimore, Md. : 1950), Jg. 202 (2019-03-15), Heft 6, S. 1680-1685
Veröffentlichung:	Bethesda, MD : American Association of Immunologists ; <i>Original Publication</i>: Baltimore : Williams & Wilkins, c1950-, 2019
Medientyp:	academicJournal
ISSN:	1550-6606 (electronic)
DOI:	10.4049/jimmunol.1800898
Schlagwort:	Animals Interleukin-10 immunology Lymphocyte Activation immunology Mice Mice, Inbred C57BL Mice, Knockout Lymphocyte Activation Gene 3 Protein Antigens, CD immunology Autoimmunity immunology Encephalomyelitis, Autoimmune, Experimental immunology Inflammation immunology Interleukins immunology T-Lymphocytes, Regulatory immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [J Immunol] 2019 Mar 15; Vol. 202 (6), pp. 1680-1685. <i>Date of Electronic Publication: </i>2019 Jan 30. MeSH Terms: Antigens, CD / immunology ; Autoimmunity / immunology ; Encephalomyelitis, Autoimmune, Experimental / immunology ; Inflammation / immunology ; Interleukins / immunology ; T-Lymphocytes, Regulatory / immunology ; Animals ; Interleukin-10 / immunology ; Lymphocyte Activation / immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Lymphocyte Activation Gene 3 Protein References: Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10190-10195. (PMID: 28874534) ; Mucosal Immunol. 2016 Jan;9(1):137-45. (PMID: 26013006) ; Semin Immunol. 2011 Dec;23(6):438-45. (PMID: 21893418) ; JCI Insight. 2018 Apr 5;3(7):. (PMID: 29618655) ; J Immunol. 2009 May 1;182(9):5748-56. (PMID: 19380822) ; Nat Immunol. 2006 Sep;7(9):929-36. (PMID: 16906167) ; Nat Immunol. 2007 Dec;8(12):1372-9. (PMID: 17994023) ; Nat Immunol. 2007 Dec;8(12):1363-71. (PMID: 17994025) ; Nat Immunol. 2007 Feb;8(2):191-7. (PMID: 17136045) ; Front Immunol. 2017 Sep 25;8:1184. (PMID: 28993775) ; J Immunol. 2004 Sep 15;173(6):3871-7. (PMID: 15356135) ; J Immunol. 2003 May 15;170(10):4886-90. (PMID: 12734330) ; Annu Rev Immunol. 2015;33:417-43. (PMID: 25861977) ; Nat Immunol. 2007 Dec;8(12):1380-9. (PMID: 17994022) ; J Immunol. 2007 Sep 1;179(5):3268-75. (PMID: 17709543) ; Semin Immunol. 2011 Jun;23(3):202-8. (PMID: 21840222) ; Exp Mol Med. 2013 Oct 04;45:e46. (PMID: 24091748) ; J Immunol. 2013 Apr 1;190(7):3225-34. (PMID: 23455508) Grant Information: R01 AI125247 United States AI NIAID NIH HHS; R21 AI121524 United States AI NIAID NIH HHS Substance Nomenclature: 0 (Antigens, CD) ; 0 (Il27 protein, mouse) ; 0 (Interleukins) ; 130068-27-8 (Interleukin-10) ; 0 (Lymphocyte Activation Gene 3 Protein) ; 0 (Lag3 protein, mouse) Entry Date(s): Date Created: 20190201 Date Completed: 20200110 Latest Revision: 20221207 Update Code: 20231215 PubMed Central ID: PMC6401226

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Cutting Edge: IL-27 Attenuates Autoimmune Neuroinflammation via Regulatory T Cell/Lag3-Dependent but IL-10-Independent Mechanisms In Vivo.