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Reeler heterozygous mice (reln +/- ) are seemingly normal but haplodeficient in reln, a gene implicated in autism. Structural/neurochemical alterations in the reln +/- brain are subtle and difficult to demonstrate. Therefore, the usefulness of these mice in translational research is still debated. As evidence implicated several synapse-related genes in autism and the cerebellar vermis is structurally altered in the condition, we have investigated the expression of synaptophysin 1 (SYP1) and contactin 6 (CNTN6) within the vermis of reln +/- mice. Semi-thin plastic sections of the vermis from adult mice of both sexes and different genotypes (reln +/- and reln +/+ ) were processed with an indirect immunofluorescence protocol. Immunofluorescence was quantified on binary images and statistically analyzed. Reln +/- males displayed a statistically significant reduction of 11.89% in the expression of SYP1 compared to sex-matched wild-type animals, whereas no differences were observed between reln +/+ and reln +/- females. In reln +/- male mice, reductions were particularly evident in the molecular layer: 10.23% less SYP1 than reln +/+ males and 5.84% < reln +/+ females. In reln +/- females, decrease was 9.84% versus reln +/+ males and 5.43% versus reln +/+ females. Both reln +/- males and females showed a stronger decrease in CNTN6 expression throughout all the three cortical layers of the vermis: 17-23% in the granular layer, 24-26% in the Purkinje cell layer, and 9-14% in the molecular layer. Altogether, decrease of vermian SYP1 and CNTN6 in reln +/- mice displayed patterns compatible with the structural modifications of the autistic cerebellum. Therefore, these mice may be a good model in translational studies.

Titel:	Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.
Autor/in / Beteiligte Person:	Castagna, C ; Merighi, A ; Lossi, L
Link:	Full Text Finder (Volltext)
Zeitschrift:	Cellular and molecular neurobiology, Jg. 39 (2019-08-01), Heft 6, S. 833-856
Veröffentlichung:	1999- : New York : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York : Plenum Press, c1981-, 2019
Medientyp:	academicJournal
ISSN:	1573-6830 (electronic)
DOI:	10.1007/s10571-019-00683-7
Schlagwort:	Animals Cerebellar Vermis pathology Female Genotype Heterozygote Male Mice Reelin Protein Cell Adhesion Molecules, Neuronal metabolism Cerebellar Vermis metabolism Extracellular Matrix Proteins metabolism Nerve Tissue Proteins metabolism Serine Endopeptidases metabolism Synaptophysin metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Cell Mol Neurobiol] 2019 Aug; Vol. 39 (6), pp. 833-856. <i>Date of Electronic Publication: </i>2019 May 16. MeSH Terms: Cell Adhesion Molecules, Neuronal / metabolism ; Cerebellar Vermis / metabolism ; Extracellular Matrix Proteins / metabolism ; Nerve Tissue Proteins / metabolism ; Serine Endopeptidases / metabolism ; Synaptophysin / metabolism ; Animals ; Cerebellar Vermis / pathology ; Female ; Genotype ; Heterozygote ; Male ; Mice ; Reelin Protein References: Neuroreport. 1999 Apr 26;10(6):1329-34. (PMID: 10363948) ; J Neurosci. 1999 Sep 1;19(17):7326-33. (PMID: 10460239) ; Neuron. 1999 Nov;24(3):739-50. (PMID: 10595523) ; Behav Brain Res. 2000 Jul;112(1-2):107-17. (PMID: 10862941) ; J Neurogenet. 1996 Dec;11(1-2):45-58. (PMID: 10876649) ; Nat Genet. 2000 Sep;26(1):93-6. (PMID: 10973257) ; Eur J Neurosci. 2001 Apr;13(7):1303-10. 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(PMID: 9767397) Grant Information: CASC_FFABR_17_02 MIUR Italian Ministry of Education and Research Contributed Indexing: Keywords: Cerebellum; Contactin 6; Heterozygous; Reelin; Synapses; Synaptophysin 1; Vermis Substance Nomenclature: 0 (Cell Adhesion Molecules, Neuronal) ; 0 (Extracellular Matrix Proteins) ; 0 (Nerve Tissue Proteins) ; 0 (Reelin Protein) ; 0 (Synaptophysin) ; 0 (contactin 6 protein, mouse) ; EC 3.4.21.- (Reln protein, mouse) ; EC 3.4.21.- (Serine Endopeptidases) Entry Date(s): Date Created: 20190518 Date Completed: 20191217 Latest Revision: 20211204 Update Code: 20240513

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Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.